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Cholecalciferol, also known as Vit D3, is a fat-soluble prohormone. Vitamin D has many functions including the regulation of calcium and phosphorus levels in blood, the promotion of bone formation and mineralization, and aid to the immune system by supporting phagocyctosis, anti-tumor activity, and immunomodulatory functions. A deficiency of vitamin D can be due to many causes including inadequate dietary intake, insufficient sunlight, malabsorption problems, inability to convert vitamin D into its active metabolite, kidney or liver impairment and many others. Vitamin D occurs naturally only in fish. It is produced in the skin when UVB radiation from sunlight reacts with 7-dehydrocholesterol (a derivative of cholesterol) to form pre-vitamin D3. 1
In the OMOP vocabulary 8842 is a Standard Concept that represents the unit nanogram per milliliter (ng/mL)
5
200.00
A typical range of values for serum cholecalciferol is 20 to 60 ng/mL, with values less than 12.5 ng/mL considered a deficiency. 2 There exist studies 3 that exhibit patients with values less than 10 ng/mL 3, while vitamin d3 toxicity is said to occur when results are >= 150 ng/mL 4. This information combined with a data-driven approach to empirically establish possible low and high values, leads us to choose 5 and 200.