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Co-authored-by: Thomas B. Mooney <[email protected]>
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susannasiebert and tmooney authored Jul 22, 2023
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When selecting a transcript set in the Variant Info panel, this panel will
show details about the neoantigen candidates the transcripts in the set code
for and as well as details on the transcripts itself.
for and as well as details on the transcripts themselves.

The Peptide Candidates from Selected Transcript Set tab shows a list of
mutant and matched wildtype peptides and their IC50 binding
affinity to the patient HLA alleles. Only neoantigen candidate were at least
affinity to the patient HLA alleles. Only neoantigen candidates where at least
one peptide-MHC binding prediction falls within the `--aggregate-inclusion-threshold`
will be shown in this table. For HLA alleles were the peptide is not
will be shown in this table. For HLA alleles where the peptide is not
well-binding the prediction details will show `X`. This table also shows the
mutant position, whether or not the neoantigen candidate has any problematic
positions, and whether or not it failed the anchor criteria. This helps in
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## Adding Comments to Variants

When reviewing neoantigen candidates in pVACseq, users are able to add
comments one each variant, for example, describing what additional review is
necessary. Please note, that comments are not saved until the "Update Comment
comments on each variant, for example, describing what additional review is
necessary. Please note that comments are not saved until the "Update Comment
Section" button is pressed.


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