This repository has been archived by the owner on Mar 19, 2024. It is now read-only.
forked from ramics/HIVIntact
-
Notifications
You must be signed in to change notification settings - Fork 0
Commit
This commit does not belong to any branch on this repository, and may belong to a fork outside of the repository.
- Loading branch information
Showing
3 changed files
with
157 additions
and
78 deletions.
There are no files selected for viewing
This file contains bidirectional Unicode text that may be interpreted or compiled differently than what appears below. To review, open the file in an editor that reveals hidden Unicode characters.
Learn more about bidirectional Unicode characters
This file contains bidirectional Unicode text that may be interpreted or compiled differently than what appears below. To review, open the file in an editor that reveals hidden Unicode characters.
Learn more about bidirectional Unicode characters
This file contains bidirectional Unicode text that may be interpreted or compiled differently than what appears below. To review, open the file in an editor that reveals hidden Unicode characters.
Learn more about bidirectional Unicode characters
Original file line number | Diff line number | Diff line change |
---|---|---|
@@ -0,0 +1,71 @@ | ||
import dataclasses | ||
from dataclasses import dataclass | ||
from Bio import Seq, SeqRecord | ||
|
||
import util.coordinates as coords | ||
import util.wrappers as wrappers | ||
|
||
@dataclass | ||
class ReferenceIndex: | ||
value: int | ||
|
||
|
||
@dataclass | ||
class AlignedSequence: | ||
this: Seq | ||
reference: Seq | ||
alignment: (str, str) = dataclasses.field(default=None) | ||
coordinates_mapping: list[int] = dataclasses.field(default=None) | ||
|
||
|
||
def get_alignment(self): | ||
if not self.alignment: | ||
self.alignment = wrappers.mafft([self.reference, self.this]) | ||
|
||
return self.alignment | ||
|
||
|
||
def aligned_reference(self): | ||
return self.get_alignment()[0] | ||
|
||
|
||
def aligned_this(self): | ||
return self.get_alignment()[1] | ||
|
||
|
||
def map_index(self, index): | ||
if not self.coordinates_mapping: | ||
self.coordinates_mapping = coords.map_positions(self.aligned_reference(), self.aligned_this()) | ||
|
||
if not isinstance(index, int): | ||
raise TypeError(f"Expected integer as index", index) | ||
|
||
return self.coordinates_mapping[index] | ||
|
||
|
||
def index(self, index): | ||
if isinstance(index, ReferenceIndex): | ||
index = self.map_index(index) | ||
|
||
return self.this[index] | ||
|
||
|
||
def slice(self, first, last): | ||
if isinstance(first, ReferenceIndex): | ||
first = self.map_index(first) | ||
if isinstance(last, ReferenceIndex): | ||
last = self.map_index(last) | ||
|
||
newthis = self.this[first:(last + 1)] | ||
newreference = self.reference[self.map_index(first):(self.map_index(last) + 1)] | ||
# TODO: calculate new "coordinates_mapping" and new "alignment" from these indexes. | ||
return Sequence(this=newthis, reference=newreference) | ||
|
||
|
||
def reverse(self): | ||
newthis = SeqRecord.SeqRecord(Seq.reverse_complement(this.seq), | ||
id = this.id + " [REVERSED]", | ||
name = this.name | ||
) | ||
|
||
return Sequence(this=newthis, reference=self.reference) |