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Annotation_G2
A thorough description of the complex annotation within the .smbl
-files can be found in the Metadata section. The scope of this particular section was to identify possible shortcomings of the MIRIAM-annotation, that is used in the .sbml
-language. As illustrated in figure 1 the guidelines for the general idea of the MIRIAM annotation is to bundle the references, model information and the annotations in one comprehensive tool.
Figure 1: According to [1] the MIRIAM guidelines are composed of three parts: 1. Reference correspondence, 2. Attribution annotation, and 3. External resource annotation.
There are different ways of accessing the metadata knitted in the *.sbml
-files. You could use
- Notepad ++, v8.1, a free source code editor and Notepad replacement that supports several languages. Here you would only want to make minor channges e.g. correcting URLs oder vCards as you do not have a front end editor.
- SemanticSBML, a tool published in 2009 under GNU public license with a mighty range of MIRIAM-compliant annotation options as describes in [2]. Unfortunately the URL seems to be no longer available.
- COPASI, v4.33.246, a biochemical system simulator but your annotations will only be readable within Copasi itself and therefore lack interoperability.
[1] Combine.org
[2] Liebermeister, Wolfram; Krause, Falko; Uhlendorf, Jannis; Lubitz, Timo; Klipp, Edda (2009): SemanticSBML: a tool for annotating, checking, and merging of biochemical models in SBML format. In: Nat Prec. DOI: 10.1038/npre.2009.3093.1.
You made it through the wiki paragraphs of the high flyer group 2. Follow along the further creation of the COMBINE archive on the pages of group 3.
Bioinformatics & Systems biology SS 2021
- Synopsis Group 1
- Sources of Bachmann model
- Software tools for simulation
- How to build a Fully Featured COMBINE Archive?
- Communication channels
- Provision of a template for documentation
- Schedule (draft)
- Review of results
- COMBINE Archive (Testversion!)
- Synopsis Group 2
- Finding of SBML models
- Comparison of SBML models
- The chosen one
- Simulation tools
- Metadata
- Improving metadata annotations
- Synopsis Group 3
- SBGN Maps for Bachmann model
- Choice of SBGN language
- Tool to draw the SBGN Map
- SBGN-Map Drawing, Validation & Beautification
- Integration into COMBINE Archive
- Synopsis Group 4
- Selection of experiments
- Selection of SED-ML tool(s)
- Generation of SED-ML file(s)
- Integration into COMBINE Archive
- Test of SED-ML files and COMBINE Archive