additional trial by trial metrics - bias and plotting updates

src/aind_dynamic_foraging_basic_analysis/metrics/trial_metrics.py

@@ -1,19 +1,23 @@
 """
     Tools for computing trial by trial metrics
-    df_trials = compute_all_trial_metrics(nwb)
+    df_trials = compute_trial_metrics(nwb)
+    df_trials = compute_bias(nwb)
 
 """
 
+import pandas as pd
 import numpy as np
 
+import aind_dynamic_foraging_models.logistic_regression.model as model
+
 # TODO, we might want to make these parameters metric specific
 WIN_DUR = 15
 MIN_EVENTS = 2
 
 
-def compute_all_trial_metrics(nwb):
+def compute_trial_metrics(nwb):
     """
-    Computes all trial by trial metrics
+    Computes trial by trial metrics
 
     response_rate,          fraction of trials with a response
     gocue_reward_rate,      fraction of trials with a reward
@@ -27,35 +31,148 @@ def compute_all_trial_metrics(nwb):
         print("You need to compute df_trials: nwb_utils.create_trials_df(nwb)")
         return
 
-    df = nwb.df_trials.copy()
+    df_trials = nwb.df_trials.copy()
 
-    df["RESPONDED"] = [x in [0, 1] for x in df["animal_response"].values]
+    df_trials["RESPONDED"] = [x in [0, 1] for x in df_trials["animal_response"].values]
     # Rolling fraction of goCues with a response
-    df["response_rate"] = (
-        df["RESPONDED"].rolling(WIN_DUR, min_periods=MIN_EVENTS, center=True).mean()
+    df_trials["response_rate"] = (
+        df_trials["RESPONDED"].rolling(WIN_DUR, min_periods=MIN_EVENTS, center=True).mean()
     )
 
     # Rolling fraction of goCues with a response
-    df["gocue_reward_rate"] = (
-        df["earned_reward"].rolling(WIN_DUR, min_periods=MIN_EVENTS, center=True).mean()
+    df_trials["gocue_reward_rate"] = (
+        df_trials["earned_reward"].rolling(WIN_DUR, min_periods=MIN_EVENTS, center=True).mean()
     )
 
     # Rolling fraction of responses with a response
-    df["RESPONSE_REWARD"] = [
-        x[0] if x[1] else np.nan for x in zip(df["earned_reward"], df["RESPONDED"])
+    df_trials["RESPONSE_REWARD"] = [
+        x[0] if x[1] else np.nan for x in zip(df_trials["earned_reward"], df_trials["RESPONDED"])
     ]
-    df["response_reward_rate"] = (
-        df["RESPONSE_REWARD"].rolling(WIN_DUR, min_periods=MIN_EVENTS, center=True).mean()
+    df_trials["response_reward_rate"] = (
+        df_trials["RESPONSE_REWARD"].rolling(WIN_DUR, min_periods=MIN_EVENTS, center=True).mean()
     )
 
     # Rolling fraction of choosing right
-    df["WENT_RIGHT"] = [x if x in [0, 1] else np.nan for x in df["animal_response"]]
-    df["choose_right_rate"] = (
-        df["WENT_RIGHT"].rolling(WIN_DUR, min_periods=MIN_EVENTS, center=True).mean()
+    df_trials["WENT_RIGHT"] = [x if x in [0, 1] else np.nan for x in df_trials["animal_response"]]
+    df_trials["choose_right_rate"] = (
+        df_trials["WENT_RIGHT"].rolling(WIN_DUR, min_periods=MIN_EVENTS, center=True).mean()
     )
 
+    # TODO, add from process_nwb
+    # trial duration (stop-time - start-time) (start/stop time, or gocue to gocue?)
+    # n_licks_left (# of left licks in response window)
+    # n_licks_left_total (# of left licks from goCue to next go cue)
+    # Same for Right, same for all
+    # intertrial choices (boolean)
+    # number of intertrial choices
+    # number of intertrial switches
+    # response switch or repeat
+
     # Clean up temp columns
-    drop_cols = ["RESPONDED", "RESPONSE_REWARD", "WENT_RIGHT"]
-    df = df.drop(columns=drop_cols)
+    drop_cols = [
+        "RESPONDED",
+        "RESPONSE_REWARD",
+        "WENT_RIGHT",
+    ]
+    df_trials = df_trials.drop(columns=drop_cols)
+
+    return df_trials
+
+
+def compute_bias(nwb):
+    """
+    Computes side bias by fitting a logistic regression model
+    returns trials table with the following columns:
+    bias, the side bias
+    bias_ci_lower, the lower confidence interval on the bias
+    bias_ci_upper, the uppwer confidence interval on the bias
+    """
+
+    # Parameters for computing bias
+    n_trials_back = 5
+    max_window = 200
+    cv = 1
+    compute_every = 10
+    BIAS_LIMIT = 10
+
+    # Make sure trials table has been computed
+    if not hasattr(nwb, "df_trials"):
+        print("You need to compute df_trials: nwb_utils.create_trials_df(nwb)")
+        return
+
+    # extract choice and reward
+    df_trials = nwb.df_trials.copy()
+    df_trials["choice"] = [np.nan if x == 2 else x for x in df_trials["animal_response"]]
+    df_trials["reward"] = [
+        any(x) for x in zip(df_trials["earned_reward"], df_trials["extra_reward"])
+    ]
+
+    # Set up lists to store results
+    bias = []
+    ci_lower = []
+    ci_upper = []
+    C = []
+
+    # Iterate over trials and compute
+    compute_on = np.arange(compute_every, len(df_trials), compute_every)
+    for i in compute_on:
+        # Determine interval to compute on
+        start = np.max([0, i - max_window])
+        end = i
+
+        # extract choice and reward
+        choice = df_trials.loc[start:end]["choice"].values
+        reward = df_trials.loc[start:end]["reward"].values
+
+        # Determine if we have valid data to fit model
+        unique = np.unique(choice[~np.isnan(choice)])
+        if len(unique) == 0:
+            # no choices, report bias confidence as (-inf, +inf)
+            bias.append(np.nan)
+            ci_lower.append(-BIAS_LIMIT)
+            ci_upper.append(BIAS_LIMIT)
+            C.append(np.nan)
+        elif len(unique) == 2:
+            # Fit model
+            out = model.fit_logistic_regression(
+                choice, reward, n_trial_back=n_trials_back, cv=cv, fit_exponential=False
+            )
+            bias.append(out["df_beta"].loc["bias"]["bootstrap_mean"].values[0])
+            ci_lower.append(out["df_beta"].loc["bias"]["bootstrap_CI_lower"].values[0])
+            ci_upper.append(out["df_beta"].loc["bias"]["bootstrap_CI_upper"].values[0])
+            C.append(out["C"])
+        elif unique[0] == 0:
+            # only left choices, report bias confidence as (-inf, 0)
+            bias.append(-1)
+            ci_lower.append(-BIAS_LIMIT)
+            ci_upper.append(0)
+            C.append(np.nan)
+        elif unique[0] == 1:
+            # only right choices, report bias confidence as (0, +inf)
+            bias.append(+1)
+            ci_lower.append(0)
+            ci_upper.append(BIAS_LIMIT)
+            C.append(np.nan)
+
+    # Pack results into a dataframe
+    df = pd.DataFrame()
+    df["trial"] = compute_on
+    df["bias"] = bias
+    df["bias_ci_lower"] = ci_lower
+    df["bias_ci_upper"] = ci_upper
+    df["bias_C"] = C
+
+    # merge onto trials dataframe
+    df_trials = pd.merge(
+        nwb.df_trials.drop(columns=["bias", "bias_ci_lower", "bias_ci_upper"], errors="ignore"),
+        df[["trial", "bias", "bias_ci_lower", "bias_ci_upper"]],
+        how="left",
+        on=["trial"],
+    )
+
+    # fill in bias on non-computed trials
+    df_trials["bias"] = df_trials["bias"].bfill().ffill()
+    df_trials["bias_ci_lower"] = df_trials["bias_ci_lower"].bfill().ffill()
+    df_trials["bias_ci_upper"] = df_trials["bias_ci_upper"].bfill().ffill()
 
-    return df
+    return df_trials