PhD_project

In silico, epigenomic and functional investigations of resistance to IDH inhibitors in acute myeloid leukemia

• 2nd year plan
• Points meetings
• Introduction
• Organisation
• Analysis
  • In silico analysis
  • In vitro analysis
• Presentations
• Conferences
• Bibliography

2nd year plan and ideas {#year2}

Points meeting {#meetings}

Introduction {#intro}

An introduction of the thesis topic with some bibliography on AML, IDHm, epigenomic and stress in cancer.

Organisation {#orga}

• Weekly to-do lists
  The weekly to-do lists updated every days if needed.
• Weekly advances
  The weekly advances updated day by day.

Analysis {#analysis}

In silico analysis {#silico}

• Tutorial rMATS
• Meeting notes
  Notes for and about meetings
• Cell lines notes
  Notes about cell lines like HL60 and MOLM14 specificities
• Cell line analysis on HL60 and MOLM14 IDHm +/- IDHi Affymetrix
• Patients samples analysis on Koichi and Verhaak dataset RNAseq & affymetrix
• Methylation analysis on Koichi's cohort Patient sample + CD34+ samples
• RNA splicing analysis
• Notes on sequencing
• Side projects

In vitro analysis {#vitro}

• Notes on Wet lab
• Experiments done on wet lab

Presentations {#presentations}

• Cell symposia CDRC

Conferences {#conf}

• CRCT conferences

Bibliography {#biblio}

• Weekly biblio
• Papers read and notes
• List of potential papers
• Teams working on close field