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1,930 changes: 1,035 additions & 895 deletions pathways/WP4932/WP4932.gpml
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85 changes: 42 additions & 43 deletions pathways/WP5123/WP5123.gpml
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<?xml version="1.0" encoding="UTF-8"?>
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Mitochondrial fatty acid oxidation disorders" Data-Source="WikiPathways" Version="WP5123_r126633" Author="[DeSl, Egonw, Ash iyer, AlexanderPico, Khanspers]" Last-Modified="20230607202256" Organism="Homo sapiens">
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Mitochondrial fatty acid oxidation disorders" Data-Source="WikiPathways" Version="WP5123_r126872" Author="[DeSl, Egonw, Ash iyer, AlexanderPico, Khanspers]" Last-Modified="20230628194032" Organism="Homo sapiens">
<Comment Source="WikiPathways-description">Fatty Acids (FAs) consists of several chain lengths (short, medium and long chain), which all need to be converted to CoA-bound esters to cross the inner mitochondrial membrane. The long-chain lengths however also need additional carnitine esterification.

Several diseases are linked to the proteins in this pathway, which can be categorized into four groups: 1. entry of long-chain FAs into mitochondria disorders; 2. intra-mitochondrial beta-oxidation membrane-bound proteins defects involving long-chain FAs; 3. intra-mitochondrial beta-oxidation matrix proteins defects involving short and medium-chain FAs; 4. impaired electron transfer to Oxidative phosphorylation (OXPHOS) system.

This pathway has been inspired by Chapter 17 of the book of Blau (ISBN 3642403360 (978-3642403361)), edition 4 and build on top of the original [https://www.wikipathways.org/instance/WP368_r117795 'Mitochondrial long chain fatty acid beta-oxidation pathway'].

Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP368 CPTAC Assay Portal]</Comment>
<Comment Source="WikiPathways-description">test</Comment>
<BiopaxRef>de7</BiopaxRef>
<BiopaxRef>d8e</BiopaxRef>
<Graphics BoardWidth="1950.3333333333335" BoardHeight="970.0" />
Expand Down Expand Up @@ -976,21 +975,57 @@ Proteins on this pathway have targeted assays available via the [https://assays.
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<Biopax>
<bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
<bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">carnitine palmitoyltransferase I deficiency</bp:TERM>
<bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:0090129</bp:ID>
<bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology>
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<bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">11826276</bp:ID>
<bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
<bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fatty acid oxidation disorders.</bp:TITLE>
<bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Annu Rev Physiol</bp:SOURCE>
<bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2002</bp:YEAR>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Rinaldo P</bp:AUTHORS>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Matern D</bp:AUTHORS>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bennett MJ</bp:AUTHORS>
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<bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
<bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">fatty acid beta degradation pathway</bp:TERM>
<bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000738</bp:ID>
<bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
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<bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
<bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">carnitine palmitoyltransferase II deficiency</bp:TERM>
<bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:0060235</bp:ID>
<bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology>
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<bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">NA</bp:ID>
<bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
<bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases, Chapter 17</bp:TITLE>
<bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ISBN 978-3-642-40337-8</bp:SOURCE>
<bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Blau, N.</bp:AUTHORS>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Duran, M.</bp:AUTHORS>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gibson, K.M.</bp:AUTHORS>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Donisi-Vici, C.</bp:AUTHORS>
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<bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
<bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">carnitine palmitoyltransferase I deficiency pathway</bp:TERM>
<bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0002574</bp:ID>
<bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
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<bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
<bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">carnitine-acylcarnitine translocase deficiency</bp:TERM>
<bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0002506</bp:ID>
<bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
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<bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
<bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">carnitine palmitoyltransferase I deficiency</bp:TERM>
<bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:0090129</bp:ID>
<bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology>
</bp:openControlledVocabulary>
<bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
<bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">fatty acid beta oxidation pathway</bp:TERM>
<bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000738</bp:ID>
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Expand All @@ -1007,47 +1042,11 @@ Proteins on this pathway have targeted assays available via the [https://assays.
<bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:0111585</bp:ID>
<bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology>
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<bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
<bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">carnitine palmitoyltransferase II deficiency</bp:TERM>
<bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:0060235</bp:ID>
<bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology>
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<bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
<bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">classic metabolic pathway</bp:TERM>
<bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000002</bp:ID>
<bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
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<bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fatty acid oxidation disorders.</bp:TITLE>
<bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Annu Rev Physiol</bp:SOURCE>
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<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Matern D</bp:AUTHORS>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bennett MJ</bp:AUTHORS>
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<bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
<bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">carnitine-acylcarnitine translocase deficiency</bp:TERM>
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<bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
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<bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">fatty acid beta oxidation pathway</bp:TERM>
<bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000738</bp:ID>
<bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
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<bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="de7">
<bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">NA</bp:ID>
<bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
<bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases, Chapter 17</bp:TITLE>
<bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ISBN 978-3-642-40337-8</bp:SOURCE>
<bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2014</bp:YEAR>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Blau, N.</bp:AUTHORS>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Duran, M.</bp:AUTHORS>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gibson, K.M.</bp:AUTHORS>
<bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Donisi-Vici, C.</bp:AUTHORS>
</bp:PublicationXref>
</Biopax>
</Pathway>

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