Update README.md

README.md

@@ -150,7 +150,7 @@ As Clinotator keeps the NCBI xml results in memory, there is a significant memor
 
 <dl>
 	<dt>Clinotator Raw Score (CTRS)</dt>
-	<dd>A weighted metric of pathogenicity based on submitter type, assertion type and assertion age. The type of submitter is weighted based on expertise, with regular clinical assertions unweighted at 1.00, expert reviewers receiving a 1.10 and practice guidelines receiving a score of 1.25.<br /><br /> The age of the assertion is weighted as new data is incorporated into assertions as well as previous data, creating a larger set of evidence over time. For the first two years, there is no weight, then there is a 10% reduction in weight per year through 6 years , at which point the penalty stays at a static 50% weight reduction thereafter.<br /><br /> The assertion type is the largest weight, with values of: Benign(B) = -6, Likely benign(LB) = -3, Uncertain significance(US) = -0.3, Likely pathogenic(LP) = 3 and Pathogenic(P) = 6. For more information on the weighting decisions, see our publication.<sup>5</sup></dd>
+	<dd>A weighted metric of pathogenicity based on submitter type, assertion type and assertion age. The type of submitter is weighted based on expertise, with regular clinical assertions unweighted at 1.00, expert reviewers receiving a 1.10 and practice guidelines receiving a score of 1.25.<br /><br /> The age of the assertion is weighted as new data is incorporated into assertions as well as previous data, creating a larger set of evidence over time. For the first two years, there is no weight, then there is a 10% reduction in weight per year through 6 years , at which point the penalty stays at a static 50% weight reduction thereafter.<br /><br /> The assertion type is the largest weight, with values of: Benign(B) = -6.46, Likely benign(LB) = -3.23, Uncertain significance(US) = -0.3, Likely pathogenic(LP) = 3.23 and Pathogenic(P) = 6.46. The assertion weights have been updated to reflect the distribution of 62,911 well characterized two-star variants in ClinVar as of March 2020. For more information on the weighting calibration decisions, see our publication.<sup>5</sup></dd>
 </dl>
 <dl>
 	<dt>Average Clinical Assertion Age (CTAA)</dt>