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uthsavc authored Oct 13, 2024
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This repository contains the code for the analyses in the manuscript "Quantifying higher-order epistasis: beware the chimera". In these analyses, we compare the multiplicative and the "chimeric" epistasis measures for quantifying higher-order interactions between mutations, drug, or other perturbations.

Required packages:
* Numpy
* Matplotlib
* Pandas
* itertools
* Scipy
* Seaborn
* Numpy (>= 1.23.4)
* Matplotlib (>= 3.8.0)
* Pandas (>= 2.1.1)
* Scipy (>= 1.11.2)
* Seaborn (>= 0.12.2)

Code tested using standard Macbook Pro.

To run each of the analyses, see the following notebooks. Runtime should not take more than 20 minutes. See notebooks for expected output.

## Yeast epistasis analysis

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