Skip to content

Commit

Permalink
Add PKNCA to README.md
Browse files Browse the repository at this point in the history
  • Loading branch information
billdenney committed Oct 21, 2023
1 parent 7335067 commit 6c2cbf0
Show file tree
Hide file tree
Showing 2 changed files with 32 additions and 12 deletions.
12 changes: 11 additions & 1 deletion README.Rmd
Original file line number Diff line number Diff line change
Expand Up @@ -74,7 +74,17 @@ command line.

## Example

After installed, if you use the standard interface, you can convert to Monolix with
After installed, if you use the standard interface, you can obtain new initial estimates with PKNCA:

```r
mod <-
nlmixr2(
nlmixrFun, nlmmixrData, est = "pknca",
control = pkncaControl(concu = "ng/mL", doseu = "mg", timeu = "hr", volumeu = "L")
)
```

or, you can convert to Monolix with

```r
mod <- nlmixr(nlmixrFun, nlmmixrData, est="monolix")
Expand Down
32 changes: 21 additions & 11 deletions README.md
Original file line number Diff line number Diff line change
Expand Up @@ -46,17 +46,17 @@ Otherwise you can always install from GitHub:

Babelmixr2 can help you by:

- Running your nlmixr2 model in a commercial nonlinear mixed effects
modeling tool like
[`NONMEM`](https://nlmixr2.github.io/babelmixr2/articles/running-nonmem.html)
or `Monolix`
- Running your nlmixr2 model in a commercial nonlinear mixed effects
modeling tool like
[`NONMEM`](https://nlmixr2.github.io/babelmixr2/articles/running-nonmem.html)
or `Monolix`

- Convert your [`NONMEM` model to a nlmixr2
model](https://nlmixr2.github.io/nonmem2rx/articles/convert-nlmixr2.html)
(in conjunction with `nonmem2rx`)
- Convert your [`NONMEM` model to a nlmixr2
model](https://nlmixr2.github.io/nonmem2rx/articles/convert-nlmixr2.html)
(in conjunction with `nonmem2rx`)

- Calculate scaling factors and automatically add initial conditions
based on non-compartmental analysis (using `PKNCA`)
- Calculate scaling factors and automatically add initial conditions
based on non-compartmental analysis (using `PKNCA`)

## Monolix Setup

Expand All @@ -68,8 +68,18 @@ instead of using a command line.

## Example

After installed, if you use the standard interface, you can convert to
Monolix with
After installed, if you use the standard interface, you can obtain new
initial estimates with PKNCA:

``` r
mod <-
nlmixr2(
nlmixrFun, nlmmixrData, est = "pknca",
control = pkncaControl(concu = "ng/mL", doseu = "mg", timeu = "hr", volumeu = "L")
)
```

or, you can convert to Monolix with

``` r
mod <- nlmixr(nlmixrFun, nlmmixrData, est="monolix")
Expand Down

0 comments on commit 6c2cbf0

Please sign in to comment.