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@@ -27,4 +27,7 @@ Imports: | |
withr | ||
Suggests: | ||
testthat (>= 3.0.0), | ||
fs | ||
fs, | ||
rmarkdown, | ||
knitr | ||
VignetteBuilder: knitr |
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--- | ||
title: "Interventions" | ||
output: rmarkdown::html_vignette | ||
bibliography: references.bib | ||
csl: nature.csl | ||
link-citations: true | ||
vignette: > | ||
%\VignetteIndexEntry{Interventions} | ||
%\VignetteEngine{knitr::rmarkdown} | ||
%\VignetteEncoding{UTF-8} | ||
--- | ||
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```{r, include = FALSE} | ||
knitr::opts_chunk$set( | ||
collapse = TRUE, | ||
comment = "#>" | ||
) | ||
``` | ||
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`site_file$interventions` | ||
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Interventions contains the historical intervention information for a site. It is | ||
also the section of the site file that you would modify with intervention | ||
information for future scenarios. Details, references and methods for individual | ||
interventions are shown below: | ||
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## ITNs | ||
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### ITN use | ||
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`site_file$interventions$itn_use` | ||
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Due to differences in the availability of data sources the approach for countries | ||
within sub-Saharan Africa differs to countries outside of sub-Saharan Africa: | ||
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#### Within sub-Saharan Africa | ||
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The population at risk weighted mean ITN use estimates for each site are taken | ||
from the malaria atlas project raster entitled: | ||
"Insecticide treated bednet (ITN) use version 2020". This, and other elements | ||
of the [netz R package](https://mrc-ide.github.io/netz/) are based on work by | ||
Bertozzi-Villa *et al* @bertozzi | ||
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#### Outside of sub-Saharan Africa | ||
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ITN use is much more heterogeneous outside of SSA and data are less systematically | ||
collected. As a result, there are strong assumptions associated with the historical | ||
scale and magnitude of ITN distributions. We make the assumption that any reported | ||
ITN distributions (as detailed by the world malaria report @WMR) are tarted to areas | ||
that have > 1% PfPr or > 1% PvPr at baseline. Annual distributions in these regions | ||
are then scaled so that that number of ITNs distributed is aligned with the | ||
world malaria report. | ||
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### Missing years | ||
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Available data on ITN use (via MAP @MAP or the world malaria report @ WMR) will not extend | ||
to the present year. Missing ITN use estimates to present are filled assuming a | ||
constant, continuing level of coverage. To respect the multi-year cyclical | ||
nature of ITN distribution cycles any missing estimates are filled in assuming | ||
that coverage is constant with respect to 3 years prior. For example if years | ||
2019, 2020 and 2021 are missing then 2019 == 2016, 2020 == 2017 and 2021 == 2018. | ||
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### Net type | ||
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`site_file$interventions$net_type` | ||
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It is assumed that all nets distributed prior to 2025 are standard pyrethroid | ||
(`pyrethroid_only`) bed nets. Current available net types are: pyrethroid_only, | ||
pyrethroid_pbo and pyrethroid_pyrrole. | ||
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### Net input distribution | ||
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`site_file$interventions$itn_input_dist` | ||
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We need to estimate the annual ITN distributions that would cumulatively result | ||
in our observed timeseries of ITN usage. For the we use the `fit_usage()` | ||
function from the [netz R package](https://mrc-ide.github.io/netz/). | ||
We an impose 3 year cyclical limits to the number of nets that are | ||
distributed to avoid unrealistic over-distribution. | ||
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### Pyrethroid resistance | ||
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`site_file$interventions$pyrethroid_resistance` | ||
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For each site we include an estimated level of pyrethroid insecticide resistance. | ||
This has been estimated by Tom Churcher and colleagues using spatio-temporally | ||
distributed bioassay mortality data. This work is not yet published. Therefore | ||
for attribution/citation and further information on the methods used please contact | ||
Pete Winskill or Tom Churcher. | ||
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### ITN efficacy parameters | ||
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`site_file$interventions$dn0` | ||
`site_file$interventions$rn0` | ||
`site_file$interventions$gamman` | ||
`site_file$interventions$rnm` | ||
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Given an ITN type and level of pyrethroid insecticide resistance, we can link to the | ||
corresponding estimates of the key ITN efficacy parameters. These have been | ||
estimated by Ellie Sherrard-Smith *et al* @sherrard2022. | ||
Please note that gamman is provided in units of years here, these will need to be converted to days for use in | ||
malariasimulaiton. | ||
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## IRS | ||
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### IRS coverage | ||
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`site_file$interventions$irs_cov` | ||
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As with ITNs, due to differences in the availability of data sources the approach | ||
for countries within sub-Saharan Africa differs to countries outside of | ||
sub-Saharan Africa: | ||
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#### Within sub-Saharan Africa | ||
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The population at risk weighted mean IRS coverage estimates for each site are | ||
taken from the malaria atlas project raster entitled: | ||
"Indoor Residual Spraying (IRS) coverage version 2020" @MAP. Coverage estimates | ||
are rescaled such that the country-level estimate of the number of persons protected | ||
by IRS matches the number reported in the world malaria report @WMR. | ||
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#### Outside of sub-Saharan Africa | ||
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IRS coverage is much more heterogeneous outside of SSA and data are less systematically | ||
collected. As a result, there are strong assumptions associated with the historical | ||
scale and magnitude of IRS campaigns. We make the assumption that any reported | ||
IRS campaigns (as detailed by the world malaria report @WMR) are tarted to areas | ||
that have > 1% PfPr or > 1% PvPr at baseline. Coverage in these regions | ||
are then scaled so that that number of persons protected by IRS is aligned with the | ||
world malaria report. | ||
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### IRS insecticide | ||
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`site_file$interventions$irs_insecticide` | ||
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It is assumed that a DDT-type insecticide is used prior to 2017, after which | ||
there is a switch to an actellic-like insecticide. | ||
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Current available IRS insecticide options are: ddt, actellic, bendiocarb, | ||
sumishield. | ||
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### Number of rounds of IRS per year | ||
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`site_file$interventions$irs_spray_rounds` | ||
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We assume a single IRS spray round per year. | ||
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### IRS efficacy parameters | ||
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`site_file$interventions$ls_theta` | ||
`site_file$interventions$ls_gamma` | ||
`site_file$interventions$ks_theta` | ||
`site_file$interventions$ks_gamma` | ||
`site_file$interventions$ms_theta` | ||
`site_file$interventions$ms_gamma` | ||
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Given an IRS insecticide type we can link to the | ||
corresponding estimates of the key IRS efficacy parameters. These have been | ||
estimated by Ellie Sherrard-Smith *et al* @sherrard2018. | ||
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### IRS households sprayed | ||
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It is often helpful to convert the number of persons protected by IRS into an | ||
estimate of the number of households covered. To aid this conversion we have | ||
included country-levels estimates of the average household size obtained from | ||
the UN @UNHH. | ||
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`site_file$interventions$hh_size` | ||
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### Missing years | ||
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Available data on IRS coverage (via MAP @MAP or the world malaria report @WMR) will not extend | ||
to the present year. Missing IRS coverage estimates to present are filled assuming a | ||
constant, continuing level of coverage. | ||
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## Treatment | ||
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### Coverage | ||
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`site_file$interventions$tx_cov` | ||
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The population at risk weighted mean treatment coverage of an effective | ||
antimalarial for each site are taken from the malaria atlas project raster entitled: | ||
"Effective treatment with an Antimalarial drug version 2020" @MAP. | ||
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### Drug type | ||
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`site_file$interventions$prop_act` | ||
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We estimate the proportion of treatments that are with an ACT from | ||
DHS StatCompiler data @DHS, using the indicator: | ||
"Children who took any ACT" (ID: ML_AMLD_C_ACT). | ||
For SSA estimates by year are expanded by linear interpolation between data | ||
points and an assumption of constant coverage after the most recent data point. | ||
We assume that ACT coverage is zero before 2006, when the WHO recommendation was | ||
first issued. For outside of SSA the DHS indicator is confounded by treatment | ||
for Plasmodium vivax, and we therefore assume the mean values by year from data | ||
within SSA. | ||
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### Drug provider | ||
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`site_file$interventions$prop_public` | ||
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We include an estimate of the proportion of treatments that are from the public | ||
sector `prop_public`. This is useful for costing. | ||
We use the DHS StatCompiler @DHS | ||
indicator "Children with fever for whom advice or treatment was sought, | ||
the source was a public sector facility" (ID: ML_FEVA_C_PUB). We assume a | ||
constant proportion over time by country, estimated as the mean from all | ||
country survey estimates since 2010. For countries without survey data, we | ||
assume the median across all estimates. | ||
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## Seasonal malaria chemoprevention (SMC) | ||
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### SMC coverage | ||
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`site_file$interventions$smc_cov` | ||
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Historical SMC implementation and coverage estimates are fragmented. We | ||
identify historical SMC implementation areas from maps presented by both | ||
Access SMC @access_SMC and more recently | ||
SMC alliance @SMC_alliance. We assume a linear increase in | ||
coverage post implementation initiation up to a maximum of 80% to capture an | ||
increasing number of smaller sub-national units being targeted over time. | ||
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### SMC drug | ||
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`site_file$interventions$smc_drug` | ||
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We assume that SP-AQ is used for SMC. This is currently the only available drug | ||
option. | ||
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### Number of SMC rounds delivered annualy | ||
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`site_file$interventions$smc_n_rounds` | ||
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We assumed that historical SMC is delivered over 4 rounds `smc_n_rounds`. | ||
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### SMC age range | ||
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`site_file$interventions$smc_min_age` | ||
`site_file$interventions$smc_max_age` | ||
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We assume SMC is delivered to children aged between 3 months and 5 years. | ||
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## RTS,S vaccine | ||
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`site_file$interventions$rtss_cov` | ||
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We include historical RTS,S coverage that has occurred as part of the MVIP | ||
implementation trial, sub-nationally in Malawi, Ghana and Kenya. The spatial | ||
distribution is informed from an | ||
MVIP briefing presentation @MVIP | ||
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## Perennial malaria chemoprevention (PMC). | ||
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This intervention has been known in the past as intermittent preventative treatment | ||
of infants (IPTi). | ||
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### PMC coverage | ||
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`site_file$interventions$pmc_cov` | ||
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Due to the very limited (non-trial setting) implementation of PMC historically, | ||
we assume 0 coverage. | ||
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### PMC drug | ||
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`site_file$interventions$pmc_drug` | ||
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We assume PMC would be implemented with SP. This is currently the only available | ||
drug option. | ||
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## Citations |
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--- | ||
title: "Metadata" | ||
output: rmarkdown::html_vignette | ||
bibliography: references.bib | ||
csl: nature.csl | ||
link-citations: true | ||
vignette: > | ||
%\VignetteIndexEntry{Metadata} | ||
%\VignetteEngine{knitr::rmarkdown} | ||
%\VignetteEncoding{UTF-8} | ||
--- | ||
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```{r, include = FALSE} | ||
knitr::opts_chunk$set( | ||
collapse = TRUE, | ||
comment = "#>" | ||
) | ||
``` | ||
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## Country | ||
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`site_file$country` | ||
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The ISO3c code identifying the country. The R package `countrycode` @countrycode | ||
is useful for converting between ISO3c and country names. | ||
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## Version | ||
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`site_file$version` | ||
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The year and version of the site file. | ||
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## Admininstrative level | ||
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`site_file$admin_level` | ||
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The administrative level (e.g. state, region, province) of the sites within the site file. | ||
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## Sites | ||
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`site_file$sites` | ||
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The sites within the site file. These are the named sites disaggregated to the | ||
specified administrative level. Further disaggregation may include, for example, | ||
an [urban rural split](https://mrc-ide.github.io/site/articles/pop_demog.html). | ||
We use the GADM @GADM | ||
version 4.04 administrative boundary simple feature spatial files at the first | ||
or second administrative unit level. | ||
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## Citations |
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--- | ||
title: "Seasonality" | ||
output: rmarkdown::html_vignette | ||
bibliography: references.bib | ||
csl: nature.csl | ||
link-citations: true | ||
vignette: > | ||
%\VignetteIndexEntry{Seasonality} | ||
%\VignetteEngine{knitr::rmarkdown} | ||
%\VignetteEncoding{UTF-8} | ||
--- | ||
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```{r, include = FALSE} | ||
knitr::opts_chunk$set( | ||
collapse = TRUE, | ||
comment = "#>" | ||
) | ||
``` | ||
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## Seasonality | ||
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`site_file$seasonality` | ||
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Daily rainfall global rasters for the period 2019-2021 were obtained from | ||
CHIRPS @CHIRPS using the | ||
[umbrella R package](https://mrc-ide.github.io/umbrella/). For each site we | ||
estimate the fourier series parameters representing general seasonal profiles. | ||
Please see the umbrella website for more information. | ||
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## Citations |
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