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False positive recombinants #279

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jeromekelleher opened this issue Dec 20, 2024 · 0 comments
Open

False positive recombinants #279

jeromekelleher opened this issue Dec 20, 2024 · 0 comments

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@jeromekelleher
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There seems to be a few cases in the current large ARG where we inferring recombinants due to clusters of adjacent mutations recurring, e.g.,

Screenshot from 2024-12-20 23-38-13

Note 22030--22034 all mutating together here. I'm not sure what the underlying reason for this is, but there's definitely a bunch of recombinants that have a few hundred descendants that are of these form. One example has a whole bunch of recombinant children, which is definitely suspicious:

Screenshot from 2024-12-20 23-42-34

Something to investigate for the paper. We should presumably exclude these from analyses as false positives.

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