In Infinispan 9.0.2 we introduced HTTP/2 support for REST (you may look into unRESTful Web Services with HTTP2 by Fabian Stäber video for more information). This demo shows how to use with JDK9 HTTP client (which supports HTTP/2 out of the box).
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Run Infinispan Server in a Docker container
docker run -e "APP_USER=test" -e "APP_PASS=test" jboss/infinispan-server:9.1.5.Final ../../docs/examples/configs/standalone-rest-ssl.xml --debug-
Run this demo against it.