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README.md

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 # iGEM2020 - AstroBio
-A web app that determines genes expression changes in microgravity
+AstroBio is a well-curated, open-source software and database compiling literature findings on microgravity-induced gene expression changes in yeast, bacteria, and plants. AstroBio's database contains data from published microarray and RNA-seq experiments conducted either during spaceflight or under simulated microgravity conditions. These experimental datasets were retrieved and analyzed from the NCBI Gene Expression Omnibus (GEO) database and the NCBI Sequence Read Archive (SRA) database using the R software suite. Differential expression analysis was performed on datasets that have been curated for quality based on normal density plot distributions, a sufficient number of replicates for robust statistical analysis, as well as the quantity of near 1 false discovery rates. AstroBio allows users to search a specific gene, micro-organism, species, microgravity-induced gene regulation (upregulated versus downregulated), open reading frame, microgravity conditions (space-flown experiments versus simulated-microgravity experiments), and/or assay type (RNAseq versus microarray experiments). It also allows users to compare findings from different studies and to determine whether a change in the expression of a given Saccharomyces cerevisiae gene is specific to microgravity-induced stress when compared to other stressors such as heat shock.
 
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