Synaptic architecture of leg and wing premotor control networks in Drosophila (Lesser, Azevedo, et al. 2024 Nature)

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Jasper Phelps edited this page Jul 26, 2024 · 2 revisions

Synaptic architecture of leg and wing premotor control networks in Drosophila

Ellen Lesser*, Anthony W. Azevedo*, Jasper S. Phelps, Leila Elabbady, Andrew Cook, Durafshan Sakeena Syed, Brandon Mark, Sumiya Kuroda, Anne Sustar, Anthony Moussa, Chris J. Dallmann, Sweta Agrawal, Su-Yee J. Lee, Brandon Pratt, Kyobi Skutt-Kakaria, Stephan Gerhard, Ran Lu, Nico Kemnitz, Kisuk Lee, Akhilesh Halageri, Manuel Castro, Dodam Ih, Jay Gager, Marwan Tammam, Sven Dorkenwald, Forrest Collman, Casey Schneider-Mizell, Derrick Brittain, Chris S. Jordan, Thomas Macrina, Michael Dickinson, Wei-Chung Allen Lee☨, John C. Tuthill☨

Published in Nature, available online as of June 26, 2024: https://www.nature.com/articles/s41586-024-07600-z
Preprint posted to bioRxiv on May 31, 2023: https://www.biorxiv.org/content/10.1101/2023.05.30.542725
GitHub repository with the paper's analysis code: https://github.com/tuthill-lab/Lesser_Azevedo_2023

Public data releases

The neuron reconstructions and connectivity data below were exported from FANC on May 25th, 2023 – specifically CAVE materialization v604, which has a timestamp of 1685002201.254304 (use datetime.datetime.fromtimestamp(1685002201.254304, datetime.timezone.utc) in Python).

Proofread motor neuron reconstructions

See Connectomic reconstruction of a female Drosophila ventral nerve cord (Azevedo, Lesser, Phelps, Mark et al. 2024 Nature)'s public data release section, and see links in the section headers below.

Proofread leg premotor neuron reconstructions

Premotor neurons targeting the "coxa swing" motor neuron module:
Local interneurons / Intersegmental neurons / Ascending neurons / Sensory neurons / Descending neurons

Premotor neurons targeting the "coxa stance" motor neuron module:
Local interneurons / Intersegmental neurons / Ascending neurons / Sensory neurons / Descending neurons

Premotor neurons targeting the "Femur/Trochanter extend" motor neuron module:
Local interneurons / Intersegmental neurons / Ascending neurons / Sensory neurons / Descending neurons

Premotor neurons targeting the "Femur/Trochanter flex" motor neuron module:
Local interneurons / Intersegmental neurons / Ascending neurons / Sensory neurons / Descending neurons

Premotor neurons targeting the "Femur reductor" motor neuron module:
Local interneurons / Intersegmental neurons / Ascending neurons / Sensory neurons / Descending neurons

Premotor neurons targeting the "Tibia extend" motor neuron module:
Local interneurons / Intersegmental neurons / Ascending neurons / Sensory neurons / Descending neurons

Premotor neurons targeting the "Tibia flex A" motor neuron module:
Local interneurons / Intersegmental neurons / Ascending neurons / Sensory neurons / Descending neurons

Premotor neurons targeting the "Tibia flex B" motor neuron module:
Local interneurons / Intersegmental neurons / Ascending neurons / Sensory neurons / Descending neurons

Premotor neurons targeting the "Tibia flex C" motor neuron module:
Local interneurons / Intersegmental neurons / Ascending neurons / Sensory neurons / Descending neurons

Premotor neurons targeting the "Substrate grip" (claw control) motor neurons:
Local interneurons / Intersegmental neurons / Ascending neurons / Sensory neurons / Descending neurons

Premotor neurons targeting the "Tarsus control" motor neurons:
Local interneurons / Intersegmental neurons / Ascending neurons / Sensory neurons / Descending neurons

Proofread wing premotor neuron reconstructions

Premotor neurons targeting the DLM motor neurons:
Local interneurons / Intersegmental neurons / Ascending neurons / Sensory neurons / Descending neurons

Premotor neurons targeting the DVM motor neurons:
Local interneurons / Intersegmental neurons / Ascending neurons / Sensory neurons / Descending neurons

Premotor neurons targeting the "Tension" motor neuron module:
Local interneurons / Intersegmental neurons / Ascending neurons / Sensory neurons / Descending neurons

Premotor neurons targeting the "Steering A" motor neuron module:
Local interneurons / Intersegmental neurons / Ascending neurons / Sensory neurons / Descending neurons

Premotor neurons targeting the "Steering B" motor neuron module:
Local interneurons / Intersegmental neurons / Ascending neurons / Sensory neurons / Descending neurons

Premotor neurons targeting the "Steering C" motor neuron module:
Local interneurons / Intersegmental neurons / Ascending neurons / Sensory neurons / Descending neurons

Premotor neurons targeting the "Steering D" motor neuron module:
Local interneurons / Intersegmental neurons / Ascending neurons / Sensory neurons / Descending neurons

Premotor neurons targeting the hg2 motor neurons:
Local interneurons / Intersegmental neurons / Ascending neurons / Sensory neurons / Descending neurons

Premotor-to-motor neuron connectivity matrices

TODO

Hemilineage identities for proofread local and intersegmental premotor neurons

GABAergic lineages

13A / 9A / 13B / 6B / 5B / 3B / 6A / 0A / 11B

Glutamatergic lineages

14A / 21A / 8A / 16 / 2A

Cholinergic lineages

22A / 3A / 4B / 20A / 1A / 23B / 11A / 18B / 7B / 19B / 12A / 8B / 17A

For FANC community members

The neurons discussed in this paper are annotated with "Lesser Azevedo et al. 2024" in the neuron_information CAVE table.

#proofreading-projects posts related to this publication:

todo