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+Tool	Description	Pros	Cons
+**[org.Xx.eg.db](https://bioconductor.org/packages/release/bioc/vignettes/AnnotationDbi/inst/doc/IntroToAnnotationPackages.pdf)**	Query gene feature information for the organism of interest	gene ID conversion, biotype and coordinate information	only latest genome build available
+**[EnsDb.Xx.vxx](http://bioconductor.org/packages/devel/bioc/vignettes/ensembldb/inst/doc/ensembldb.html)**	Transcript and gene-level information directly fetched from Ensembl API (similar to TxDb, but with filtering ability and versioned by Ensembl release)	easy functions to extract features, direct filtering	Not the most up-to-date annotations, more difficult to use than some packages
+**[TxDb.Xx.UCSC.hgxx.knownGene](https://bioconductor.org/packages/release/bioc/vignettes/GenomicFeatures/inst/doc/GenomicFeatures.pdf)**	UCSC database for transcript and gene-level information or can create own *TxDb* from an SQLite database file using the *GenomicFeatures* package	feature information, easy functions to extract features	only available current and recent genome builds - can create your own, less up-to-date with annotations than Ensembl
+**[annotables](https://github.com/stephenturner/annotables)**	Gene-level feature information immediately available for the human and model organisms	super quick and easy gene ID conversion, biotype and coordinate information	static resource, not updated regularly
+**[biomaRt](https://bioconductor.org/packages/release/bioc/vignettes/biomaRt/inst/doc/biomaRt.html)**	An R package version of the Ensembl [BioMart online tool](http://www.ensembl.org/biomart/martview/70dbbbe3f1c5389418b5ea1e02d89af3)	all Ensembl database information available, all organisms on Ensembl, wealth of information	
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