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Move variants to GRCh38 #204

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susannasiebert opened this issue Dec 2, 2021 · 2 comments
Open

Move variants to GRCh38 #204

susannasiebert opened this issue Dec 2, 2021 · 2 comments

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@susannasiebert
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  • Decide on a stop date for adding GRCh37
  • Allow only addition/editing for GRCh38 coordinates
  • Make CIViCbot revisions to move existing coordinates to GRCh38
  • Make change so that users can manually enter the ClinGen allele registry ID and not provide coordinates. Fetch GRCh38 coordinates automatically. We will need to determine a logic for identifying the representative transcript.

Other things to decide:

  • Do we want to save GRCh37 coordinates alongside GRCh38?
@susannasiebert
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See original issue here: griffithlab/civic-server#429

@kkrysiak
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Updated gnomAD only supports 38. MANE transcripts and enhancements of myvariant.info are the same.

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