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- I have made a first pass over the headmodel_eeg_bem tutorial - I updated some of the FAQs - I updated the pipeline figures and added plotting at every step - the plotting is not yet explicitly documented in the EEG BEM tutorial itself - I also renamed (also on the download server) the folders with the tutorial data
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In FieldTrip a volume conduction model is represented as a MATLAB structure which is usually indicated with the variable name **vol**. It describes how the currents flow through the tissue, not where they originate from. In general it consists of a description of the geometry of the head, a description of the conductivity of the tissue, and mathematical parameters that are derived from these. Whether and how the mathematical parameters are described depends on the computational solution to the forward problem either by numerical approximations, such as the boundary element and finite element method (BEM and FEM), or by exact analytical solutions (e.g., for spherical models). | ||
A volume conduction model of the head, also known as a head model, is represented in FieldTrip as a MATLAB structure. It describes how the currents flow through the tissue, not where they originate from. In general it consists of a description of the geometry of the tissue(s), a description of the conductivity of the tissue(s), and mathematical parameters that are derived from these. Whether and how the mathematical parameters are described depends on the computational solution to the forward problem either by numerical approximations, such as the boundary element and finite element method (BEM and FEM), or by exact analytical solutions (e.g., for spherical models). | ||
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The more accurate the description of the geometry of the head or the source, the better the quality of the forward model. There are many types of head models which, to various degrees, take the individual anatomy into account. The different head models available in FieldTrip are listed [here](/faq/what_kind_of_volume_conduction_models_are_implemented). |
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The EEG/MEG signals measured on the scalp do not directly reflect the location of the activated neurons. To reconstruct the location and the time-course or spectral content of a source in the brain, various source-localization methods are available. You can read more about the different methods in review papers suggested [here](/references_to_implemented_methods#references_to_review_papers). | ||
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The level of the activity at a source location is estimated from | ||
The activity in the brain responsible for the EEG or MEG signals is estimated from | ||
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1. the EEG/MEG activity measured on or around the scalp | ||
2. the spatial arrangement of the electrodes/gradiometers (**sensor positions**), | ||
3. the geometrical and conductive properties of the head (**head model**) | ||
4. the location of the source (**source model**) | ||
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Using this information, source estimation comprises two major steps: (1) Estimation of the potential or field distribution for a known source and for a known model of the head is referred to as **forward modeling**. (2) Estimation of the unknown sources corresponding to the measured EEG or MEG is referred to as **inverse modeling**. | ||
Using this information, source estimation comprises two major steps: (1) Estimation of the EEG potential or MEG field distribution for a known source is referred to as **forward modeling**. (2) Estimation of the unknown sources corresponding to the measured EEG or MEG is referred to as **inverse modeling**. | ||
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The forward solution can be computed when the head model, the sensor positions and the source is given. For distributed source models and for scanning approaches (such as beamforming), the source model is discretizing the brain volume into a volumetric or surface grid. When the forward solution is computed, the **lead field matrix** (= channels X source points matrix) is calculated for each grid point taking into account the head model and the sensor positions. | ||
The forward solution can be computed when the head model, the sensor positions and the model for the source are given. For distributed source models and for scanning approaches (such as beamforming), the source model consists of a discrete description of the the brain volume or of the cortical sheet in many voxels or vertices. When the forward solution is computed, the **lead field matrix** (= channels X source points matrix) is calculated for each point, taking into account the head model and the sensor positions. | ||
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A prerequisite of forward modeling is that the geometrical description of all elements (sensor positions, head model and source model) is registered in the same coordination system with the same units. There are different "conventions" how to define a coordinate system, but the precise coordinate system is not relevant, as long as all data is expressed in it consistently (i.e. in the same coordinate system). [Here](/faq/coordsys) read more about how the different head and mri coordinate systems are defined. The MEG sensors by default are defined relative to anatomical landmarks of the head (the fiducial coils), therefore when the anatomical images are also aligned to these landmarks, the MEG sensors do not need to be re-aligned. EEG data is typically not aligned to the head, therefore, the electrodes have to be re-aligned prior to source-reconstruction (see also [this faq](/faq/how_to_coregister_an_anatomical_mri_with_the_gradiometer_or_electrode_positions) and [this example](/example/electrodes2bem)). | ||
A prerequisite of forward modeling is that the geometrical description of all geometrical elements (sensor positions, head model and source model) is registered in the same coordination system and expressed with the same units (mm, cm, or m). There are different conventions for coordinate systems. The precise coordinate system is not relevant, as long as all data is expressed consistently. [Here](/faq/coordsys) you can read more about how the different head and MRI coordinate systems are defined. For most MEG systems, the gradometer sensors are by default defined relative to head localizer coils or anatomical landmarks, therefore when the anatomical MRI are aligned to the same landmarks, the position of the MEG sensors matches the MRI. EEG data is typically not explicitly aligned relatively to the head, therefore, the EEG electrodes also have to be re-aligned prior to source reconstruction (see also [this faq](/faq/how_to_coregister_an_anatomical_mri_with_the_gradiometer_or_electrode_positions) and [this example](/example/electrodes2bem)). | ||
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{% include image src="/assets/img/shared/tutorial/sourcelocalization_background/figure1.png" width="500" %} | ||
{% include image src="/assets/img/shared/tutorial/sourcelocalization_background/figure1.png" width="600" %} | ||
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_Figure 1. Major steps in source reconstruction_ | ||
_Figure 1. Overall outline of the pipeline used for source reconstruction_ |
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