Skip to content

Commit

Permalink
added masoli_et_al_2020b
Browse files Browse the repository at this point in the history
  • Loading branch information
Luca Leonardo Bologna committed Jun 10, 2020
1 parent c059fb8 commit e8c4844
Show file tree
Hide file tree
Showing 2 changed files with 17 additions and 5 deletions.
10 changes: 5 additions & 5 deletions 2020/masoli_et_al_2020b/masoli_et_al_2020b.html
Original file line number Diff line number Diff line change
Expand Up @@ -89,7 +89,7 @@ <h5 class="title-style">Cerebellar Golgi cell models predict dendritic processin
</p>
<p>
<strong>DOI: </strong>
<a href="https://10.1101/2020.05.13.093906" target="_blank">
<a href="https://doi.org/10.1101/2020.05.13.093906" target="_blank">
<span class="color_link">https://10.1101/2020.05.13.093906</span>
</a>
</p>
Expand All @@ -98,16 +98,16 @@ <h5 class="title-style">Cerebellar Golgi cell models predict dendritic processin
<a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">
<span class="color_link">Creative Commons Attribution (CC BY) license</span>
</a>&nbsp;applies for all files.&nbsp;Under this Open Access license
anyone&nbsp; may copy, distribute, or reuse the files as long as the authors and the original source are properly cited.
anyone&nbsp;may copy, distribute, or reuse the files as long as the authors and the original source are properly cited.
</p>
</div>
<div class="note rounded">
<h5>Abstract:</h5>
The Golgi cells are the main inhibitory interneurons of the cerebellar granular layer. Although recent works have highlighted the complexity of their dendritic organization and synaptic inputs, the mechanisms through which these neurons integrate complex input patterns remained unknown. Here we have used 8 detailed morphological reconstructions to develop multicompartmental models of Golgi cells, in which Na, Ca, and K channels were distributed along dendrites, soma, axonal initial segment and axon. The models faithfully reproduced a rich pattern of electrophysiological and pharmacological properties and predicted the operating mechanisms of these neurons. Basal dendrites turned out to be more tightly electrically coupled to the axon initial segment than apical dendrites. During synaptic transmission, parallel fibers caused slow Ca-dependent depolarizations in apical dendrites that boosted the axon initial segment encoder and Na-spike backpropagation into basal dendrites, while inhibitory synapses effectively shunted backpropagating currents. This oriented dendritic processing set up a coincidence detector controlling voltage-dependent NMDA receptor unblock in basal dendrites, which, by regulating local calcium influx, may provide the basis for spike-timing dependent plasticity anticipated by theory.
</div>
<h5>Resources</h5>
<p>Electrophysiological data available on the Knowledge graph.
One model (more will be added) used in the paper, is available at the links reported below, grouped into the following categories:
<p>Electrophysiological data available in the HBP <a href="https://kg.ebrains.eu/search/?facet_type[0]=Dataset">Knowledge Graph</a>.
One of the models used in the paper is available at the links reported below, grouped into the following categories:
</p>
<ul class="collapsible" data-collapsible="expandable">
<li class="active">
Expand All @@ -116,7 +116,7 @@ <h5>Resources</h5>
</div>
<!-- option: leak_remove -->
<div class="collapsible-body ">
<p>The morphology for the dendrites and soma is in .asc format. Modified from neuromorpho.org </p>
<p>The morphology for the dendrites and the soma is in .asc format. Modified from neuromorpho.org </p>
<!-- <p>The explanation of how to setup a custom axon, or a specific dendritic sectionlist is available at the following link:</p> -->

<div style="margin-left:25px">
Expand Down
12 changes: 12 additions & 0 deletions index.html
Original file line number Diff line number Diff line change
Expand Up @@ -149,6 +149,18 @@ <h5 style="font-family: 'Merriweather', serif; text-align:center; line-height: 1
</a>
<td>
</tr>
<tr>
<td>
<a href="2020/masoli_et_al_2020b/masoli_et_al_2020b.html" target="_blank" class="waves-effect waves-light">
Masoli S, Ottaviani A, D’Angelo E (2020) <i> Cerebellar Golgi cell models predict dendritic processing and mechanisms of synaptic plasticity.</i> bioRxiv.
</a>
</td>
<td class="ta-center">
<a href="https://collab.humanbrainproject.eu/#/collab/84490" target="_blank" class="waves-effect waves-light">
<img class="hbp-icon" src="static/imgs/hbp_diamond_120.png">
</a>
<td>
</tr>
<tr>
<td>
<a href="2020/saray_et_al_2020/saray_et_al_2020.html" target="_blank" class="waves-effect waves-light">
Expand Down

0 comments on commit e8c4844

Please sign in to comment.