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diagnostics and lower FPR

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@brentp brentp released this 08 Jan 19:59
· 41 commits to master since this release

v0.2.3

  • save disc and split counts and output a plot as QC
  • annotate: annotate with up and downstream 5KB. so any gene within 5kb will be annotated.
  • smoove merge now outputs a plot that shows the number of split and discordant reads for each sample.
  • smoove now filters about 25% more split reads by looking at how the read is consumed
    this results in a 5% reduction in false positive genome-in-a-bottle deletions > 1KB while leaving
    the true positives unchanged relative to version 0.2.2. (Thanks @ernfrid for feedback on this feature).