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# Wonderful Wednesdays | ||
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**June 12th, 2024**. | ||
**July 10th, 2024**. | ||
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The challenge for the next webinar is about platform trial designs. Details can be found [here](https://github.com/VIS-SIG/Wonderful-Wednesdays/tree/master/data/2024/2024-06-12). | ||
The challenge for the next webinar is about responder definition derivation. Details can be found [here](https://github.com/VIS-SIG/Wonderful-Wednesdays/tree/master/data/2024/2024-07-10). | ||
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For more on PSI and wonderful wednesdays see https://www.psiweb.org/sigs-special-interest-groups/visualisation/welcome-to-wonderful-wednesdays | ||
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We will make the submissions available to the community together with highlights of the strength and limitations through our [blog](https://vis-sig.github.io/blog/). Over time, this will lead to a gallery of visualizations for others to learn from. | ||
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## May data set | ||
## July data set | ||
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**Upcoming July 10th, 2024 webinar**. The current data example focuses on [platform trial designs](https://github.com/VIS-SIG/Wonderful-Wednesdays/tree/master/data/2024/2024-06-12). | ||
**Upcoming August 14th, 2024 webinar**. The current data example focuses on [responder definition derivation](https://github.com/VIS-SIG/Wonderful-Wednesdays/tree/master/data/2024/2024-07-10). | ||
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Submit your visualisations [here](https://docs.google.com/forms/d/e/1FAIpQLSdNAaiuUAD89LAdQm5KNnLWs-MjqA4pzX2VHAwN7iqwoKpi-Q/viewform) or send them to <[email protected]>! | ||
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## Next Webinar | ||
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**July 12th, 2024**. | ||
**August 14th, 2024**. | ||
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## Previous data sets | ||
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* [platform trial designs](https://github.com/VIS-SIG/Wonderful-Wednesdays/tree/master/data/2024/2024-05-08) | ||
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* [platform trial designs](https://github.com/VIS-SIG/Wonderful-Wednesdays/tree/master/data/2024/2024-06-12) | ||
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## Downloading single files | ||
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# Responder definition | ||
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## Background | ||
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- When a new patient-reported outcome (PRO) is developed, there is interest in deriving the following, to support interpretation of data collected using the new tool: | ||
- Minimal Clinically Important Difference (MCID) / Responder Definition (RD) | ||
- Meaningful Between-Group Difference | ||
- Meaningful Score Categories | ||
- These are usually derived by using an existing, validated measure as the ‘gold standard’ to quantify e.g. disease status | ||
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## Data | ||
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- Simulated dataset: 1000 subjects, 2 timepoints (Baseline, Week 16) | ||
- Treatment allocation is not important and not provided | ||
- At each time point, data is provided for two tools: | ||
- PGIS – the “gold standard” – graded on a 4-point scale (‘None’, ‘Mild’, ‘Moderate’, ‘Severe’) | ||
- ‘NEWTOOL’ – the new measure, scored on an 11-point numeric rating scale from 0 to 10 | ||
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## Challenge | ||
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Use visualisations to support in the derivation in any or all of the following: | ||
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- MCID | ||
- Meaningful between-group difference | ||
- Meaningful score categories |
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