Merge branch 'develop' into fix/phytanoyl_alpha_ox

SysBioChalmers · Jan 8, 2024 · a7370db · a7370db
2 parents 18a27be + 9ae41e9
commit a7370db
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diff --git a/data/deprecatedIdentifiers/deprecatedReactions.tsv b/data/deprecatedIdentifiers/deprecatedReactions.tsv
@@ -284,3 +284,4 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR04005"	""	""	""	""	""	"RE3627C"	""	""	""	""	0	""	""	"RE3627C"
 "MAR05187"	""	"FAOXC15NADx"	""	""	""	"FAOXC15NADx"	"MNXR99293"	""	""	""	0	""	""	"FAOXC15NADx"
 "MAR05186"	""	"FAOXC15NADPx"	""	""	""	"FAOXC15NADPx"	"MNXR99292"	""	""	""	0	""	""	"FAOXC15NADPx"
+"MAR00965"	""	"FAOXC2252053m"	""	""	""	"FAOXC2252053m"	"MNXR99352"	""	""	""	0	""	""	"FAOXC2252053m"
diff --git a/model/Human-GEM.yml b/model/Human-GEM.yml
@@ -67617,6 +67617,54 @@
       - charge: -4
       - inchis: ""
       - metFrom: "Recon3D"
+    - !!omap
+      - id: "MAM20077m"
+      - name: "2-(4-carboxy-1-hydroxybutyl)thiamine diphosphate"
+      - compartment: "m"
+      - formula: "C17H25N4O10P2S3-"
+      - charge: -3
+      - inchis: "InChI=1S/C17H26N4O9P2S/c1-10-14(6-7-31(25,26)30-32(27,28)29)33-17(13(22)4-3-5-15(23)24)21(10)9-12-8-19-11(2)20-16(12)18/h8,13,22H,3-7,9H2,1-2H3,(H5-,18,19,20,23,24,25,26,27,28,29)/p+1"
+      - metFrom: ""
+    - !!omap
+      - id: "MAM20078m"
+      - name: "2-(2-methyl-1-hydroxypropyl)thiamine diphosphate"
+      - compartment: "m"
+      - formula: "C16H25N4O8N4P2S2-"
+      - charge: -2
+      - inchis: "InChI=1S/C16H26N4O8P2S/c1-9(2)14(21)16-20(8-12-7-18-11(4)19-15(12)17)10(3)13(31-16)5-6-27-30(25,26)28-29(22,23)24/h7,9,14,21H,5-6,8H2,1-4H3,(H4-,17,18,19,22,23,24,25,26)/p+1"
+      - metFrom: ""
+    - !!omap
+      - id: "MAM20079m"
+      - name: "2-(2-methyl-1-hydroxybutyl)thiamine diphosphate"
+      - compartment: "m"
+      - formula: "C17H27N4O8P2S2-"
+      - charge: -2
+      - inchis: "InChI=1S/C17H28N4O7P2S/c1-5-10(2)15(22)17-21(9-13-8-19-12(4)20-16(13)18)11(3)14(31-17)6-7-29(23,24)28-30(25,26)27/h8,10,15,22H,5-7,9H2,1-4H3,(H4-,18,19,20,23,24,25,26,27)/p+1"
+      - metFrom: ""
+    - !!omap
+      - id: "MAM20080m"
+      - name: "2-(3-methyl-1-hydroxybutyl)thiamine diphosphate"
+      - compartment: "m"
+      - formula: "C17H27N4O8P2S2-"
+      - charge: -2
+      - inchis: "InChI=1S/C17H28N4O7P2S/c1-10(2)7-14(22)17-21(9-13-8-19-12(4)20-16(13)18)11(3)15(31-17)5-6-29(23,24)28-30(25,26)27/h8,10,14,22H,5-7,9H2,1-4H3,(H4-,18,19,20,23,24,25,26,27)/p+1"
+      - metFrom: ""
+    - !!omap
+      - id: "MAM20081m"
+      - name: "2-(1-hydroxypropyl)thiamine diphosphate"
+      - compartment: "m"
+      - formula: "C15H23N4O8P2S2-"
+      - charge: -2
+      - inchis: "InChI=1S/C15H24N4O8P2S/c1-4-12(20)15-19(8-11-7-17-10(3)18-14(11)16)9(2)13(30-15)5-6-26-29(24,25)27-28(21,22)23/h7,12,20H,4-6,8H2,1-3H3,(H4-,16,17,18,21,22,23,24,25)/p+1"
+      - metFrom: ""
+    - !!omap
+      - id: "MAM20082m"
+      - name: "S-propanoyldihydrolipoamide"
+      - compartment: "m"
+      - formula: ""
+      - charge: 0
+      - inchis: ""
+      - metFrom: ""
 - reactions:
     - !!omap
       - id: "MAR03905"
@@ -70602,16 +70650,15 @@
       - metabolites: !!omap
           - MAM00671m: -1
           - MAM01596m: 1
-          - MAM01597m: -1
-          - MAM02552m: -1
-          - MAM02553m: 1
-          - MAM02774m: 1
+          - MAM02039m: -1
+          - MAM02984m: -1
+          - MAM20081m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000083123 and ENSG00000091140 and ENSG00000137992 and ENSG00000248098"
+      - gene_reaction_rule: "ENSG00000248098 and ENSG00000083123"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
-      - eccodes: "1.2.7.2"
+      - eccodes: "1.2.4.4"
       - references: "PMID:2649080;PMID:283398;PMID:3718468;PMID:9381974"
       - subsystem:
           - "Propanoate metabolism"
@@ -80955,11 +81002,10 @@
       - id: "MAR04599"
       - name: "2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating)"
       - metabolites: !!omap
-          - MAM00670m: -1
-          - MAM01596m: 1
-          - MAM02039m: -1
           - MAM02393m: -1
           - MAM02899m: 1
+          - MAM02984m: 1
+          - MAM20077m: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "(ENSG00000105953 and ENSG00000119689) or (ENSG00000181192 and ENSG00000119689)"
@@ -82362,11 +82408,10 @@
       - id: "MAR06419"
       - name: "(S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)"
       - metabolites: !!omap
-          - MAM00669m: -1
-          - MAM01596m: 1
-          - MAM02039m: -1
           - MAM02393m: -1
           - MAM02856m: 1
+          - MAM02984m: 1
+          - MAM20079m: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000083123 and ENSG00000137992 and ENSG00000248098"
@@ -82399,11 +82444,10 @@
       - id: "MAR06421"
       - name: "4-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)"
       - metabolites: !!omap
-          - MAM01013m: -1
-          - MAM01596m: 1
-          - MAM02039m: -1
           - MAM02393m: -1
           - MAM02858m: 1
+          - MAM02984m: 1
+          - MAM20080m: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000083123 and ENSG00000137992 and ENSG00000248098"
@@ -87467,11 +87511,10 @@
       - id: "MAR06416"
       - name: "3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)"
       - metabolites: !!omap
-          - MAM00824m: -1
-          - MAM01596m: 1
-          - MAM02039m: -1
           - MAM02393m: -1
           - MAM02857m: 1
+          - MAM02984m: 1
+          - MAM20078m: -1
       - lower_bound: 0
       - upper_bound: 1000
       - gene_reaction_rule: "ENSG00000083123 and ENSG00000137992 and ENSG00000248098"
@@ -121052,7 +121095,7 @@
           - MAM03021m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000104823 or ENSG00000167969 or ENSG00000198721 or ENSG00000113790"
+      - gene_reaction_rule: "ENSG00000104823 or ENSG00000167969 or ENSG00000198721"
       - rxnNotes: ""
       - rxnFrom: "HMRdatabase"
       - eccodes: "5.3.3.8;5.3.3.-"
@@ -221984,30 +222027,6 @@
       - subsystem:
           - "Fatty acid oxidation"
       - confidence_score: 0
-    - !!omap
-      - id: "MAR00965"
-      - name: "Beta Oxidation of Long Chain Fatty Acid"
-      - metabolites: !!omap
-          - MAM00093m: -1
-          - MAM00103m: 1
-          - MAM01261m: 1
-          - MAM01597m: -1
-          - MAM02039m: 1
-          - MAM02040m: -1
-          - MAM02041m: 1
-          - MAM02552m: -1
-          - MAM02553m: 1
-          - MAM02630m: -1
-      - lower_bound: 0
-      - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000117054 or ENSG00000122971"
-      - rxnNotes: ""
-      - rxnFrom: "Recon3D"
-      - eccodes: "4.2.1.74"
-      - references: ""
-      - subsystem:
-          - "Fatty acid oxidation"
-      - confidence_score: 0
     - !!omap
       - id: "MAR00968"
       - name: "Beta Oxidation of Long Chain Fatty Acid"
@@ -222046,7 +222065,7 @@
           - MAM02553m: 1
       - lower_bound: 0
       - upper_bound: 1000
-      - gene_reaction_rule: "ENSG00000117054 or ENSG00000122971"
+      - gene_reaction_rule: "(ENSG00000115361 and ENSG00000167969 and ENSG00000104823 and ENSG00000104325 and ENSG00000084754 and ENSG00000138029) or (ENSG00000115361 and ENSG00000198721 and ENSG00000104823 and ENSG00000104325 and ENSG00000084754 and ENSG00000138029) or (ENSG00000177646 and ENSG00000167969 and ENSG00000104823 and ENSG00000104325 and ENSG00000084754 and ENSG00000138029) or (ENSG00000177646 and ENSG00000198721 and ENSG00000104823 and ENSG00000104325 and ENSG00000084754 and ENSG00000138029)"
       - rxnNotes: ""
       - rxnFrom: "Recon3D"
       - eccodes: "4.2.1.74"
@@ -304768,6 +304787,118 @@
       - subsystem:
           - "Acyl-CoA hydrolysis"
       - confidence_score: 0
+    - !!omap
+      - id: "MAR20173"
+      - name: ""
+      - metabolites: !!omap
+          - MAM00670m: -1
+          - MAM01596m: 1
+          - MAM02039m: -1
+          - MAM02984m: -1
+          - MAM20077m: 1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: "ENSG00000105953 or ENSG00000181192"
+      - rxnNotes: ""
+      - rxnFrom: ""
+      - eccodes: "1.2.4.-"
+      - references: "PMID:29752936"
+      - subsystem:
+          - "Lysine metabolism"
+      - confidence_score: 0
+    - !!omap
+      - id: "MAR20174"
+      - name: ""
+      - metabolites: !!omap
+          - MAM00824m: -1
+          - MAM01596m: 1
+          - MAM02039m: -1
+          - MAM02984m: -1
+          - MAM20078m: 1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: "ENSG00000248098 and ENSG00000083123"
+      - rxnNotes: ""
+      - rxnFrom: ""
+      - eccodes: "1.2.4.4"
+      - references: "PMID:29752936"
+      - subsystem:
+          - "Valine, leucine, and isoleucine metabolism"
+      - confidence_score: 0
+    - !!omap
+      - id: "MAR20175"
+      - name: ""
+      - metabolites: !!omap
+          - MAM00669m: -1
+          - MAM01596m: 1
+          - MAM02039m: -1
+          - MAM02984m: -1
+          - MAM20079m: 1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: "ENSG00000248098 and ENSG00000083123"
+      - rxnNotes: ""
+      - rxnFrom: ""
+      - eccodes: "1.2.4.4"
+      - references: "PMID:29752936"
+      - subsystem:
+          - "Valine, leucine, and isoleucine metabolism"
+      - confidence_score: 0
+    - !!omap
+      - id: "MAR20176"
+      - name: ""
+      - metabolites: !!omap
+          - MAM01013m: -1
+          - MAM01596m: 1
+          - MAM02039m: -1
+          - MAM02984m: -1
+          - MAM20080m: 1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: "ENSG00000248098 and ENSG00000083123"
+      - rxnNotes: ""
+      - rxnFrom: ""
+      - eccodes: "1.2.4.4"
+      - references: "PMID:29752936"
+      - subsystem:
+          - "Valine, leucine, and isoleucine metabolism"
+      - confidence_score: 0
+    - !!omap
+      - id: "MAR20177"
+      - name: ""
+      - metabolites: !!omap
+          - MAM02393m: -1
+          - MAM02984m: 1
+          - MAM20081m: -1
+          - MAM20082m: 1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: "ENSG00000248098 and ENSG00000083123 and ENSG00000137992"
+      - rxnNotes: ""
+      - rxnFrom: ""
+      - eccodes: "1.2.4.4"
+      - references: "PMID:29752936"
+      - subsystem:
+          - "Propanoate metabolism"
+      - confidence_score: 0
+    - !!omap
+      - id: "MAR20178"
+      - name: ""
+      - metabolites: !!omap
+          - MAM01597m: -1
+          - MAM01701m: 1
+          - MAM02774m: 1
+          - MAM20082m: -1
+      - lower_bound: 0
+      - upper_bound: 1000
+      - gene_reaction_rule: "ENSG00000137992"
+      - rxnNotes: ""
+      - rxnFrom: ""
+      - eccodes: "1.2.4.4"
+      - references: "PMID:3718468"
+      - subsystem:
+          - "Propanoate metabolism"
+      - confidence_score: 0
 - genes:
     - !!omap
       - id: "ENSG00000000419"

diff --git a/model/metabolites.tsv b/model/metabolites.tsv
@@ -8450,3 +8450,9 @@ mets	metsNoComp	metBiGGID	metKEGGID	metHMDBID	metChEBIID	metPubChemID	metLipidMa
 "MAM01435m"	"MAM01435"	""	"C02528"	"HMDB0000518"	"CHEBI:16755"	"10133"	"LMST04010032"	""	"HC00958"	"HC00958"	"MNXM1183"	""	"MAM03318m"
 "MAM01729e"	"MAM01729"	""	""	"HMDB0002250"	""	"168381"	""	""	""	"M01729"	"MNXM51468;MNXM588354"	""	"MAM03540e"
 "MAM00853c"	"MAM00853"	""	""	""	""	""	""	"CE4820"	""	"CE4820"	"MNXM164259"	""	";MAM00902c"
+"MAM20077m"	"MAM20077"	""	"C22667"	""	"CHEBI:29144"	"5460642"	""	""	""	""	"MNXM37367"	""	""
+"MAM20078m"	"MAM20078"	""	"C15976"	"HMDB0006866"	"CHEBI:48522"	"23724626"	""	""	""	""	"MNXM739354"	""	""
+"MAM20079m"	"MAM20079"	""	"C15978"	""	"CHEBI:29141"	"5460645"	""	""	""	""	"MNXM35248"	""	""
+"MAM20080m"	"MAM20080"	""	"C15974"	""	"CHEBI:29143"	"5460643"	""	""	""	""	"MNXM36616"	""	""
+"MAM20081m"	"MAM20081"	""	"C21017"	""	"CHEBI:190398"	"92042789"	""	""	""	""	"MNXM164098"	""	""
+"MAM20082m"	"MAM20082"	""	"C21018"	""	""	""	""	""	""	""	"MNXM164758"	""	""
diff --git a/model/reactions.tsv b/model/reactions.tsv
@@ -160,7 +160,7 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR00153"	"R00925"	"ACS2"	""	"r0218"	""	"ACS2"	"MNXR106753;MNXR95222"	"HMR_0153"	"RCR10460"	""	0	"RHEA:20374"	"RHEA:20373"	"HMR_0153"
 "MAR03212"	"R00924"	"PPCOAOm"	""	"r0683"	""	"PPCOAOm;r0683"	"MNXR103101"	"HMR_3212;HMR_3211"	"RCR11088;RCR14348"	""	0	""	""	"HMR_3212;MAR03211"
 "MAR03797"	"R00925"	"ACCOALm"	""	"r0219"	""	"ACCOALm"	"MNXR106753;MNXR95222"	"HMR_3797"	"RCR14211"	""	0	"RHEA:20376"	"RHEA:20373"	"HMR_3797"
-"MAR03800"	""	"OBDHm"	""	"r1154"	""	"r1154"	"MNXR102133"	"HMR_3800"	"RCR10461"	""	0	""	""	"HMR_3800"
+"MAR03800"	"R10996"	"OBDHm"	""	"r1154"	""	"r1154"	"MNXR114300"	"HMR_3800"	"RCR10461"	""	0	""	""	"HMR_3800"
 "MAR04105"	"R00233"	"MCD"	""	"r0063"	""	"MCD"	"MNXR101412"	"HMR_4105"	"RCR10285"	""	0	"RHEA:18782"	"RHEA:18781"	"HMR_4105"
 "MAR04106"	"R00233"	"MCDm"	""	"r0064"	""	"MCDm"	"MNXR101412"	"HMR_4106"	"RCR11089"	""	0	"RHEA:18782"	"RHEA:18781"	"HMR_4106"
 "MAR04107"	"R00233"	"MCDp"	""	"r0065"	""	"MCDp"	"MNXR101412"	"HMR_4107"	"RCR14212"	""	0	"RHEA:18782"	"RHEA:18781"	"HMR_4107"
@@ -713,7 +713,7 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR04288"	"R00716"	"SACCD3m"	"R00716M"	"r0180"	""	"SACCD3m"	"MNXR104238"	"HMR_4288"	"RCR11333"	""	0	""	"RHEA:19373"	"HMR_4288"
 "MAR04596"	"R01939"	""	"R01939C"	"r0450"	""	"AATAi"	"MNXR95160"	"HMR_4596"	"RCR10526"	""	0	""	"RHEA:12601"	"HMR_4596"
 "MAR04597"	"R01939"	""	"R01939M"	"r0450"	""	"r0450"	"MNXR95160"	"HMR_4597"	"RCR11334"	""	0	""	"RHEA:12601"	"HMR_4597"
-"MAR04599"	"R01940"	"2OXOADOXm"	"R01940M;R01933M"	"r0451;r0448"	""	"r0451;2OXOADOXm"	"MNXR102246;MNXR107241"	"HMR_4599;HMR_4239"	"RCR10318;RCR11332"	""	0	"RHEA:12189"	"RHEA:12188"	"HMR_4599;MAR04239;HMR_4239"
+"MAR04599"	"R13167"	"2OXOADOXm"	"R01940M;R01933M"	"r0451;r0448"	""	"r0451;2OXOADOXm"	""	"HMR_4599;HMR_4239"	"RCR10318;RCR11332"	""	0	""	""	"HMR_4599;MAR04239;HMR_4239"
 "MAR04667"	"R02313"	"r0525"	"R02313C"	"r0525"	""	"r0525"	"MNXR105347"	"HMR_4667"	"RCR11335"	""	0	""	"RHEA:24520"	"HMR_4667"
 "MAR04668"	"R02315"	"SACCD4m"	""	"r0526"	""	"SACCD4m"	"MNXR104236"	"HMR_4668"	"RCR11336"	""	0	""	"RHEA:10020"	"HMR_4668"
 "MAR04737"	"R03102"	""	"R03102M"	"r0594"	""	"r0594"	"MNXR95158"	"HMR_4737"	"RCR10319"	""	0	""	"RHEA:12308"	"HMR_4737"
@@ -789,7 +789,7 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR06417"	"R02662"	"OIVD2m"	"RE3326M;R03171M"	"r0561;r0600"	""	"RE3326M;r0561;OIVD2m"	"MNXR107649;MNXR97451"	"HMR_6417;HMR_3748"	"RCR14349;RCR14420"	""	0	""	"RHEA:18865"	"HMR_6417;HMR_3748;MAR03748"
 "MAR06419"	"R04225"	"OIVD3m"	"R04225C;R03171M"	"r0670;r0602"	""	"r0670;OIVD3m"	"MNXR108745;MNXR94911"	"HMR_6419;HMR_3780"	"RCR11381;RCR10345"	""	0	""	""	"HMR_6419;HMR_3780;MAR03780"
 "MAR06420"	"R03174"	"OIVD3m"	"R03171M"	"r0604;r0602"	""	"r0604;OIVD3m"	"MNXR108002;MNXR97450"	"HMR_6420;HMR_3780"	"RCR14350;RCR10345"	""	0	""	""	"HMR_6420;HMR_3780;MAR03780"
-"MAR06421"	"R01702;R01651"	"OIVD1m"	"R01702C;R03171M"	"r0386;r0601"	""	"r0386;OIVD1m"	"MNXR107132;MNXR95029;MNXR102172;MNXR107999"	"HMR_6421;HMR_3767"	"RCR11382;RCR14422"	""	0	""	"RHEA:25177"	"HMR_6421;HMR_3767;MAR03767_1"
+"MAR06421"	"R07602"	"OIVD1m"	"R01702C;R03171M"	"r0386;r0601"	""	"r0386;OIVD1m"	"MNXR144603;MNXR183200"	"HMR_6421;HMR_3767"	"RCR11382;RCR14422"	""	0	""	""	"HMR_6421;HMR_3767;MAR03767"
 "MAR06422"	"R04097;R01651"	"OIVD1m"	"R0317M"	"r0656;r0601"	""	"r0656;OIVD1m"	"MNXR108654;MNXR97452;MNXR102172;MNXR107999"	"HMR_6422;HMR_3767"	"RCR14351;RCR14422"	""	0	""	"RHEA:25177"	"HMR_6422;MAR03767_2"
 "MAR06923"	"R01090"	"LEUTA"	""	""	""	"LEUTA"	"MNXR96229"	"HMR_6923"	"RCR10325"	""	0	""	"RHEA:18321"	"HMR_6923"
 "MAR03765"	"R01090"	"LEUTAm"	"R01090C"	"r0262"	""	"LEUTAm"	"MNXR96229"	"HMR_3765"	"RCR11383"	""	0	""	"RHEA:18321"	"HMR_3765"
@@ -1058,7 +1058,7 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR03792"	"R02048"	""	"R02048M"	"r0483"	""	"3AIBTm;r0483"	"MNXR105346"	"HMR_3792"	"RCR11523"	""	0	""	""	"HMR_3792"
 "MAR03796"	"R00926"	""	"R00926C"	"r0221"	""	"r0221"	"MNXR105315;MNXR106754"	"HMR_3796"	"RCR10119"	""	0	""	""	"HMR_3796"
 "MAR03823"	"R04203"	"HACD9m"	"R04203M"	"r0664"	""	"HACD9m"	"MNXR100550"	"HMR_3823"	"RCR11524"	""	0	""	"RHEA:13281"	"HMR_3823"
-"MAR06416"	"R01701"	"OIVD2m"	"R01701C;R03171M"	"r0385;r0600"	""	"r0385;OIVD2m"	"MNXR107131;MNXR94910"	"HMR_6416;HMR_3748"	"RCR11525;RCR14420"	""	0	""	"RHEA:13457"	"HMR_6416;HMR_3748;MAR03748"
+"MAR06416"	"R07600"	"OIVD2m"	"R01701C;R03171M"	"r0385;r0600"	""	"r0385;OIVD2m"	"MNXR142260;MNXR183199"	"HMR_6416;HMR_3748"	"RCR11525;RCR14420"	""	0	""	""	"HMR_6416;HMR_3748;MAR03748"
 "MAR03986"	""	""	""	"r1374"	""	"r1374"	"MNXR105461"	"HMR_3986"	"RCR30265"	""	0	""	""	"HMR_3986"
 "MAR03988"	"R00022"	""	"R00022C"	"r0013"	""	"r0013"	"MNXR100746;MNXR95628"	"HMR_3988"	"RCR11526"	""	0	""	"RHEA:30671"	"HMR_3988"
 "MAR04124"	"R01384"	"UDPGLDCg"	"R01384C"	"r0326"	""	"HMR_4124"	"MNXR105068"	"HMR_4124"	"RCR11527"	""	0	""	"RHEA:23916"	"HMR_4124"
@@ -8273,9 +8273,8 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR00927"	""	"FAOXC2051843x"	""	""	""	"FAOXC2051843x"	"MNXR99344"	""	""	""	0	""	""	"FAOXC2051843x"
 "MAR00930"	""	"FAOXC2242046m"	""	""	""	"FAOXC2242046m"	"MNXR99349"	""	""	""	0	""	""	"FAOXC2242046m"
 "MAR00952"	""	"FAOXC2242046x"	""	""	""	"FAOXC2242046x"	"MNXR99350"	""	""	""	0	""	""	"FAOXC2242046x"
-"MAR00965"	""	"FAOXC2252053m"	""	""	""	"FAOXC2252053m"	"MNXR99352"	""	""	""	0	""	""	"FAOXC2252053m"
 "MAR00968"	""	"FAOXC2252053x"	""	""	""	"FAOXC2252053x"	"MNXR99352"	""	""	""	0	""	""	"FAOXC2252053x"
-"MAR00970"	""	"FAOXC226205m"	""	""	""	"FAOXC226205m"	"MNXR99356"	""	""	""	0	""	""	"FAOXC226205m"
+"MAR00970"	""	"FAOXC226205m"	""	""	""	"FAOXC226205m"	"MNXR99356"	""	""	""	0	""	""	"FAOXC226205m;MAR00965"
 "MAR00972"	""	"FAOXC226205x"	""	""	""	"FAOXC226205x"	"MNXR99356"	""	""	""	0	""	""	"FAOXC226205x"
 "MAR00974"	""	"FAOXC240200x"	""	""	""	"FAOXC240200x"	"MNXR99359"	""	""	""	0	""	""	"FAOXC240200x"
 "MAR00975"	""	"FAOXC241181x"	""	""	""	"FAOXC241181x"	"MNXR99361"	""	""	""	0	""	""	"FAOXC241181x"
@@ -12974,3 +12973,9 @@ rxns	rxnKEGGID	rxnBiGGID	rxnEHMNID	rxnHepatoNET1ID	rxnREACTOMEID	rxnRecon3DID	rx
 "MAR20170"	""	""	""	""	""	""	""	""	""	""	0	"RHEA:30144"	"RHEA:30143"	""
 "MAR20171"	""	""	""	""	""	""	""	""	""	""	0	"RHEA:40060"	"RHEA:40059"	""
 "MAR20172"	""	""	""	""	""	""	""	""	""	""	0	""	""	""
+"MAR20173"	"R13166"	""	""	""	""	""	""	""	""	""	0	""	""	""
+"MAR20174"	"R07599"	""	""	""	""	""	"MNXR145675"	""	""	""	0	""	""	""
+"MAR20175"	"R07603"	""	""	""	""	""	"MNXR145677"	""	""	""	0	""	""	""
+"MAR20176"	"R07601"	""	""	""	""	""	"MNXR145679"	""	""	""	0	""	""	""
+"MAR20177"	"R10997"	""	""	""	""	""	"MNXR114301"	""	""	""	0	""	""	""
+"MAR20178"	"R10998"	""	""	""	""	""	"MNXR114302"	""	""	""	0	""	""	""