This repository contains files for F-actin model in beta cell
This project is building beta-cell model including F-actin network and modeling interactions between insulin granules and F-actins. The cell model is generated and sampled using Integrative Modeling Platform (IMP).
IMP version: 2.11.0 stable release
written by: Huaiqing Cao, Sali lab, Shanghaitech University.
This project now contains two individual models: the interaction model between single granule and F-actin, and the cell model containing multiple granles and F-actins.
The interaction model is generated to model the association/dissociation process of granule and F-actin. New interaction model can be generated by running: python3 scripts/actin_granule_binding/granule_actin_interaction.py
The cell model contains multiple F-actins aiming to construct F-actin networks. New cell model can be generated by running: python3 scripts/actin_granule_binding/multiple_filament_model.py
Currently this script is not able to generate crosslinked F-actin network. It can only model the interactions between individual F-actins which are in Brownian motion.