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title: Meta-analytic decoding of the cortical gradient of functional connectivity | ||
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abstract: | | ||
Macroscale gradients have emerged as a central principle for understanding functional brain | ||
organization. Previous studies have demonstrated that a principal gradient of connectivity in | ||
the human brain exists, with unimodal primary sensorimotor regions situated at one end, and | ||
transmodal regions associated with the default mode network and representative of abstract | ||
functioning at the other. The functional significance and interpretation of macroscale gradients | ||
remains a central topic of discussion in the neuroimaging community, with some studies | ||
demonstrating that gradients may be described using meta-analytic functional decoding techniques. | ||
However, additional methodological development is necessary to more fully leverage available | ||
meta-analytic methods and resources and quantitatively evaluate their relative performance. | ||
Here, we conducted a comprehensive series of analyses to investigate and improve the framework | ||
of data-driven, meta-analytic methods, thereby establishing a principled approach for gradient | ||
segmentation and functional decoding. We found that a small number of segments determined by a | ||
K-means segmentation approach and an LDA-based meta-analysis combined with the NeuroQuery | ||
database was the optimal combination of methods for decoding functional connectivity gradients. | ||
Taken together, the current work aims to provide recommendations on best practices, along with | ||
flexible methods, for gradient-based functional decoding of fMRI data. | ||
message: If you use this code, please cite it as below. | ||
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repository-code: https://github.com/NBCLab/gradient-decoding | ||
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identifiers: | ||
- description: Meta-analytic decoding of the cortical gradient of functional connectivity | ||
type: doi | ||
value: https://doi.org/10.1101/2023.08.01.551505 | ||
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contact: | ||
- given-names: Julio A | ||
family-names: Peraza | ||
email: [email protected] | ||
affiliation: Department of Physics, Florida International University, Miami, FL, USA | ||
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license: Apache License 2.0 | ||
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authors: | ||
- given-names: Julio A | ||
family-names: Peraza | ||
orcid: 0000-0003-3816-5903 | ||
affiliation: Department of Physics, Florida International University, Miami, FL, USA | ||
- given-names: Taylor | ||
family-names: Salo | ||
orcid: 0000-0001-9813-3167 | ||
affiliation: Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA | ||
- given-names: Michael C | ||
family-names: Michael | ||
orcid: 0000-0002-1860-4449 | ||
affiliation: LTI Engineering and Software, Quebec City, QC, Canada | ||
- given-names: Katherine L | ||
family-names: Bottenhorn | ||
orcid: 0000-0002-7796-8795 | ||
affiliation: Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA | ||
- given-names: Jean-Baptiste | ||
family-names: Poline | ||
orcid: 0000-0002-9794-749X | ||
affiliation: Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada | ||
- given-names: Jérôme | ||
family-names: Dockès | ||
orcid: 0000-0002-5304-2496 | ||
affiliation: Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada | ||
- given-names: James D | ||
family-names: Kent | ||
orcid: 0000-0002-4892-2659 | ||
affiliation: Department of Psychology, University of Texas at Austin, Austin, TX, USA | ||
- given-names: Jessica E | ||
family-names: Bartley | ||
orcid: 0000-0001-7269-9701 | ||
affiliation: Department of Physics, Florida International University, Miami, FL, USA | ||
- given-names: Jessica S | ||
family-names: Flannery | ||
orcid: 0000-0003-3274-1578 | ||
affiliation: Department of Psychology and Neuroscience, University of North Carolina, Chapel Hill, NC, USA | ||
- given-names: Lauren D | ||
family-names: Hill-Bowen | ||
orcid: 0000-0002-9817-7757 | ||
affiliation: Department of Psychology, Florida International University, Miami, FL, USA | ||
- given-names: Rosario | ||
family-names: Pintos Lobo | ||
orcid: 0000-0002-7679-1385 | ||
affiliation: Department of Psychology, Florida International University, Miami, FL, USA | ||
- given-names: Ranjita | ||
family-names: Poudel | ||
orcid: 0000-0003-4343-1153 | ||
affiliation: Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, USA | ||
- given-names: Kimberly L | ||
family-names: Ray | ||
orcid: 0000-0003-1302-2834 | ||
affiliation: Department of Psychology, University of Texas at Austin, Austin, TX, USA | ||
- given-names: Jennifer L | ||
family-names: Robinson | ||
orcid: 0000-0001-7389-3047 | ||
affiliation: Department of Psychology, Auburn University, Auburn, AL, USA | ||
- given-names: Robert W | ||
family-names: Laird | ||
affiliation: Department of Physics, Florida International University, Miami, FL, USA | ||
- given-names: Matthew T | ||
family-names: Sutherland | ||
orcid: 0000-0002-6091-4037 | ||
affiliation: Department of Psychology, Florida International University, Miami, FL, USA | ||
- given-names: Alejandro | ||
family-names: de la Vega | ||
orcid: 0000-0001-9062-3778 | ||
affiliation: Department of Psychology, University of Texas at Austin, Austin, TX, USA | ||
- given-names: Angela R | ||
family-names: Laird | ||
orcid: 0000-0003-3379-8744 | ||
affiliation: Department of Physics, Florida International University, Miami, FL, USA |