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Added multi-shot dynamic rat kidney data
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sample_data/Rat Kidneys Dynamic MRS/demo_dynamic_mrs_multishot_fit.m
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% fit slab dynamic MRS data from repeated injections ("shots") in a single rat | ||
% as an example, does a kPL fit only (ignores alanine, bicarb) | ||
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% Data and studies described in | ||
% Hu, Simon, Peder E Z Larson, Mark Vancriekinge, Andrew M Leach, Ilwoo Park, Christine Leon, et al. | ||
% “Rapid Sequential Injections of Hyperpolarized [1-¹³C]pyruvate in Vivo Using a Sub-Kelvin, Multi-Sample DNP Polarizer.” | ||
% Magn Reson Imaging 31, no. 4 (May 2013): 490–96. | ||
% https://doi.org/10.1016/j.mri.2012.09.002. | ||
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clear all | ||
plot_flag = 1; | ||
int_range = 25; | ||
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for ratnum = 1:4; | ||
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switch ratnum | ||
case 1 | ||
Nshots = 4; | ||
lac_center = 970; | ||
pyr_hyd_center = 1020; | ||
ala_center = 1056; | ||
pyr_center = 1130; | ||
bicarb_center = 1262; | ||
case 2 | ||
Nshots = 3; | ||
lac_center = 967; | ||
pyr_hyd_center = 1018; | ||
ala_center = 1053; | ||
pyr_center = 1128; | ||
bicarb_center = 1260; | ||
case 3 | ||
Nshots = 3; | ||
lac_center = 968; | ||
pyr_hyd_center = 1019; | ||
ala_center = 1054; | ||
pyr_center = 1129; | ||
bicarb_center = 1260; | ||
case 4 | ||
Nshots = 3; | ||
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lac_center = 876; | ||
pyr_hyd_center = 927; | ||
ala_center = 963; | ||
pyr_center = 1037; | ||
bicarb_center = 1168; | ||
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case 5 | ||
Nshots = 3; | ||
lac_center = 875; | ||
pyr_hyd_center = 926; | ||
ala_center = 961; | ||
pyr_center = 1036; | ||
bicarb_center = 1168; | ||
end | ||
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clear params_fixed params_est params_fit kPL | ||
R1P_est = 1/30; R1L_est = 1/25; kPL_est = 0.01; | ||
params_fixed.R1P = R1P_est; params_fixed.R1L = R1L_est; | ||
params_est.kPL = kPL_est; | ||
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for n = 1:Nshots | ||
load(sprintf('rat%d/shot%d',ratnum,n)); | ||
pyr = real(sum(spectra_dynamic(pyr_center+[-int_range:int_range],:),1)); | ||
lac = real(sum(spectra_dynamic(lac_center+[-int_range:int_range],:),1)); | ||
[params_fit Sfit] = fit_kPL([pyr;lac] , TR, repmat(flip, [2 length(pyr)]), params_fixed, params_est, [], plot_flag); | ||
kPL(n) = params_fit.kPL; | ||
end | ||
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disp(['Rat #' int2str(ratnum) ' kPL fits: ' num2str(kPL) ' 1/s']) | ||
end |
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