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Endemicity and Periodicity

Jonathan Bloedow edited this page May 7, 2024 · 1 revision

What is the expected period of an endemic infection at steady-state?

In a toy model of a measles-like disease, where beta (proxy for R0 or infectivity), birth rate, and population are such that we are above the Critical Community Size (CCS) threshold, we might see a prevalence plot like the red curve below: image

(Generated at https://deepnote.com/app/idm/jonathanhhbs-Untitled-project-fda259dd-514c-4710-90d1-53849d90a543?POP=1000000&CBR=42&BETA=2).

For a CBR of 42 (which is relatively high), beta of 2, and a population of 1 million, we see a period of about 2 years.

But in that DeepNote dashboard one can adjust cbr and see that the period changes. Lowering just the CBR to, say, a more late-20th century Europe of say 17 produces a period of about 2000 days, though not constant:

image

Raising beta to 5 from 2 produces a period of about 900.

Adjusting population (assuming you stay above CCS threshold), doesn't seem to modify the period.

Theory

Theoretical work to explore periodicities of resonant SIR models are here (TBD).

Questions

  1. Should our models be tested in single node to confirm they exhibit periodicities consistent with theory or reference models?
  2. Is periodicity sensitive to other inputs? Which?

Seasonality

In full models of the real world, the "natural frequency" of the model is dominated by seasonal factors producing annual, biennial, or "multi-ennial" outbreaks. What if a model exhibits annual or biennial periodicity without seasonal forcing?

Damping

Note that the question of amplitude damping as a quantitative and measurable effect is omitted here, though I would note that this is something I've observed occasionally in my model version.

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