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corrected ins
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jtdendunnen authored Feb 9, 2023
1 parent 3ddc1b7 commit 928d0e2
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Expand Up @@ -24,7 +24,7 @@ Format: **"prefix""amino_acid(s)+position(s)\_deleted""delins""inserted\_seque
* the description p.Arg76\_Cys77delinsSerTrp is correct, the description p.[Arg76Ser;Cys77Trp] is not correct.
* two variants separated by one or more amino acids should be described individually and not as a “delins”.
* for all descriptions the **most C-terminal position** possible of the reference sequence is arbitrarily assigned to have been changed (_**3'rule**_).
* when the inserted amino acid sequence is large the insertion may be described by its length only, e.g. p.Arg456_Leu488delinsX[54]
* when the inserted amino acid sequence is large the insertion may be described by its length, e.g. p.Lys2\_Leu3insX[34] (open reading frame insertion) or p.Lys2\_Leu3insTer12 (translation stop in inserted sequence).
* _**NOTE**_: the inserted amino acid sequence can be derived from the description od the variant at DNA or RNA level.
* deletion/insertion variants extending the full-length amino acid sequence at the C-terminal end with one or more amino acids are described as [_Extension_](/recommendations/protein/variant/extension).
* deletion-insertion variants at the DNA or RNA level.
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