beataml.yaml

Name: Beat Acute Myeloid Leukemia (AML) 1.0
Description: |
  Beat AML 1.0 is a collaborative research program involving 11 academic medical centers who worked
  collectively to better understand  drugs and drug combinations that should be prioritized for
  further development within clinical and/or molecular subsets of acute myeloid leukemia (AML)
  patients. Beat AML 1.0 provides the largest-to-date dataset on primary acute myeloid leukemia
  samples offering genomic, clinical, and drug response.
  
  This dataset contains open Clinical Supplement and RNA-Seq Gene Expression Quantification data.

  This dataset also contains controlled Whole Exome Sequencing (WXS) and RNA-Seq Aligned Reads, WXS Annotated Somatic Mutation,
  WXS Raw Somatic Mutation, and RNA-Seq Splice Junction Quantification  
Documentation: |
  https://www.cancer.gov/about-nci/organization/ccg/blog/2019/beataml
Contact: dcf-support@datacommons.io
ManagedBy: "[Center for Translational Data Science at The University of Chicago](https://ctds.uchicago.edu/)"
UpdateFrequency: |
  Genomic Data Commons (GDC) is source of truth for this dataset; GDC offers monthly data releases,
  although this dataset may not be updated at every release.
Tags:
  - aws-pds
  - life sciences
  - cancer
  - genetic
  - genomic
  - Homo sapiens
  - STRIDES
License: "NIH Genomic Data Sharing Policy: https://gdc.cancer.gov/access-data/data-access-policies"
Resources:
  - Description: BEATAML1.0-COHORT RNA-Seq Gene Expression Quantification
    ARN: arn:aws:s3:::gdc-beataml1-cohort-phs001657-2-open
    Region: us-east-1
    Type: S3 Bucket
  - Description: BEATAML1.0-CRENOLANIB Clinical Supplement
    ARN: arn:aws:s3:::gdc-beataml1.0-crenolanib-phs001628-2-open
    Region: us-east-1
    Type: S3 Bucket
  - Description: |
      WXS/RNA-Seq Aligned Reads, WXS Annotated Somatic Mutation, WXS Raw Somatic Mutation, RNA-Seq
      Splice Junction Quantification
    ARN: arn:aws:s3:::gdc-beataml1-cohort-phs001657-2-controlled
    Region: us-east-1
    Type: S3 Bucket
    ControlledAccess: https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001657.v1.p1&phv=417530&phd=&pha=&pht=9391&phvf=&phdf=&phaf=&phtf=&dssp=1&consent=&temp=1
DataAtWork:
  Tools & Applications:
    - Title: Genomic Data Commons
      URL: https://portal.gdc.cancer.gov/projects/
      AuthorName: National Cancer Institute
      AuthorURL: https://gdc.cancer.gov/
  Publications:
    - Title: Functional Genomic Landscape of Acute Myeloid Leukemia
      URL: https://www.ncbi.nlm.nih.gov/pubmed/30333627
      AuthorName: Jeffrey W. Tyner, Cristina E. Tognon, Dan Bottomly et al.
    - Title: |
        Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular
        mechanisms
      URL: https://www.ncbi.nlm.nih.gov/pubmed/30651561
      AuthorName: Zhang H, Savage S, Schultz AR, Bottomly D, White L, Segerdell E, et al.