diff --git a/src/ert/storage/local_experiment.py b/src/ert/storage/local_experiment.py
index bef4cf46ea2..77ef7dc2f13 100644
--- a/src/ert/storage/local_experiment.py
+++ b/src/ert/storage/local_experiment.py
@@ -4,7 +4,7 @@
 from datetime import datetime
 from functools import cached_property
 from pathlib import Path
-from typing import TYPE_CHECKING, Any, Dict, Generator, List, Optional
+from typing import TYPE_CHECKING, Any, Dict, Generator, List, Optional, TypedDict
 from uuid import UUID
 
 import numpy as np
@@ -37,6 +37,15 @@
 from ert.config.responses_index import responses_index
 
 
+class ResponseConfigDict(TypedDict):
+    keys: List[str]
+
+
+def _remove_wildcard_keys(configs: Dict[str, ResponseConfigDict]):
+    for d in configs.values():
+        d["keys"] = [k for k in d["keys"] if k != "*"]
+
+
 class _Index(BaseModel):
     id: UUID
     name: str
@@ -134,9 +143,12 @@ def create(
             json.dumps(parameter_data, indent=2).encode("utf-8"),
         )
 
-        response_data = {}
+        response_data: Dict[str, ResponseConfigDict] = {}
         for response in responses or []:
             response_data.update({response.response_type: response.to_dict()})
+
+        _remove_wildcard_keys(response_data)
+
         storage._write_transaction(
             path / cls._responses_file,
             json.dumps(response_data, default=str, indent=2).encode("utf-8"),
@@ -335,9 +347,6 @@ def response_key_to_response_type(self) -> Dict[str, str]:
         mapping = {}
         for config in self.response_configuration.values():
             for key in config.keys:
-                if key == "*":
-                    continue
-
                 mapping[key] = config.response_type
 
         return mapping
@@ -368,13 +377,16 @@ def _update_response_keys(
 
         if diff:
             config.keys = sorted(set(config.keys).union(set(new_response_keys)))
+            response_config_dicts = {
+                c.response_type: c.to_dict() for c in responses_configuration.values()
+            }
+
+            _remove_wildcard_keys(response_config_dicts)
+
             self._storage._write_transaction(
                 self._path / self._responses_file,
                 json.dumps(
-                    {
-                        c.response_type: c.to_dict()
-                        for c in responses_configuration.values()
-                    },
+                    response_config_dicts,
                     default=str,
                     indent=2,
                 ).encode("utf-8"),