From 7a65bcb828fb00d443ba0b148d0a1c595f8b3f4c Mon Sep 17 00:00:00 2001
From: GitHub Action <action@github.com>
Date: Sat, 15 Jul 2023 03:05:04 +0000
Subject: [PATCH] Process GPML changes

---
 pathways/WP3301/WP3301.gpml | 295 ++++++++++++++++++------------------
 1 file changed, 147 insertions(+), 148 deletions(-)

diff --git a/pathways/WP3301/WP3301.gpml b/pathways/WP3301/WP3301.gpml
index ba9a623ac2..7358a621a8 100644
--- a/pathways/WP3301/WP3301.gpml
+++ b/pathways/WP3301/WP3301.gpml
@@ -1,17 +1,17 @@
 <?xml version="1.0" encoding="UTF-8"?>
-<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="MFAP5-mediated ovarian cancer cell motility and invasiveness" Data-Source="WikiPathways" Version="WP3301_r120029" Author="[Khanspers, Elisa, AMTan, MaintBot, Fehrhart]" Last-Modified="20211015231945" Organism="Homo sapiens">
+<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="MFAP5-mediated ovarian cancer cell motility and invasiveness" Data-Source="WikiPathways" Version="WP3301_r126996" Author="[Khanspers, Elisa, AMTan, MaintBot, Fehrhart]" Last-Modified="20230714192719" Organism="Homo sapiens">
   <Comment Source="WikiPathways-description">A graphical summary of the molecular signaling events involved in MFAP5-mediated ovarian cancer cell motility and invasiveness. 
 Based on figure 6c in [https://www.ncbi.nlm.nih.gov/pubmed/25277212 Leung et al].
 
 Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3301 CPTAC Assay Portal]</Comment>
   <BiopaxRef>a0f</BiopaxRef>
-  <Graphics BoardWidth="1014.0" BoardHeight="743.0" />
+  <Graphics BoardWidth="1014.0" BoardHeight="727.5" />
   <DataNode TextLabel="Ca2+" GraphId="a042e" Type="Metabolite" GroupRef="a1d2b">
-    <Graphics CenterX="157.72444961920516" CenterY="278.0776439089692" Width="39.34805890227585" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
+    <Graphics CenterX="164.3406961178045" CenterY="272.244310575636" Width="39.34805890227585" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
     <Xref Database="HMDB" ID="HMDB0000464" />
   </DataNode>
   <DataNode TextLabel="Troponin C" GraphId="a7bcb" Type="GeneProduct">
-    <Graphics CenterX="615.1302521008403" CenterY="447.94117647058846" Width="67.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+    <Graphics CenterX="636.796918767507" CenterY="447.94117647058846" Width="67.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
     <Xref Database="Ensembl" ID="ENSG00000114854" />
   </DataNode>
   <DataNode TextLabel="CREB1" GraphId="b1584" Type="GeneProduct">
@@ -23,7 +23,7 @@ Proteins on this pathway have targeted assays available via the [https://assays.
     <Xref Database="CAS" ID="85166-31-0" />
   </DataNode>
   <DataNode TextLabel="MFAP5" GraphId="b7eea" Type="GeneProduct">
-    <Graphics CenterX="837.2869292295234" CenterY="104.91298527443104" Width="56.67469879518069" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+    <Graphics CenterX="838.1202625628569" CenterY="104.91298527443104" Width="56.67469879518069" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
     <Xref Database="Ensembl" ID="ENSG00000197614" />
   </DataNode>
   <DataNode TextLabel="ITGB3" GraphId="ba2ae" Type="GeneProduct" GroupRef="b680b">
@@ -31,11 +31,11 @@ Proteins on this pathway have targeted assays available via the [https://assays.
     <Xref Database="Ensembl" ID="ENSG00000259207" />
   </DataNode>
   <DataNode TextLabel="TNNC1" GraphId="c359a" Type="GeneProduct">
-    <Graphics CenterX="511.9957983193268" CenterY="598.7394957983191" Width="55.50420168067238" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" />
+    <Graphics CenterX="511.9957983193268" CenterY="597.9061624649858" Width="55.50420168067238" Height="20.0" ZOrder="32768" FontSize="12" Valign="Middle" />
     <Xref Database="Ensembl" ID="ENSG00000114854" />
   </DataNode>
   <DataNode TextLabel="RYR3" GraphId="c59d3" Type="GeneProduct">
-    <Graphics CenterX="269.0" CenterY="308.0" Width="44.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+    <Graphics CenterX="266.5000000000008" CenterY="309.6666666666664" Width="44.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
     <Xref Database="Ensembl" ID="ENSG00000198838" />
   </DataNode>
   <DataNode TextLabel="DAG" GraphId="d1e91" Type="Metabolite">
@@ -59,7 +59,7 @@ Proteins on this pathway have targeted assays available via the [https://assays.
     <Xref Database="Ensembl" ID="ENSG00000065675" />
   </DataNode>
   <DataNode TextLabel="ITPR3" GraphId="ef707" Type="GeneProduct">
-    <Graphics CenterX="300.5" CenterY="335.0" Width="43.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+    <Graphics CenterX="303.8333333333333" CenterY="341.6666666666666" Width="43.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
     <Xref Database="Ensembl" ID="ENSG00000096433" />
   </DataNode>
   <DataNode TextLabel="JUN" GraphId="f4e1e" Type="GeneProduct" GroupRef="b1e44">
@@ -75,23 +75,23 @@ Proteins on this pathway have targeted assays available via the [https://assays.
     <Xref Database="Ensembl" ID="ENSG00000100030" />
   </DataNode>
   <DataNode TextLabel="Ca2+" GraphId="aa064" Type="Metabolite">
-    <Graphics CenterX="157.6740294511379" CenterY="118.07764390896921" Width="39.348058902275795" Height="20.0" ZOrder="32770" FontSize="10" Valign="Middle" Color="0000ff" />
+    <Graphics CenterX="164.34069611780453" CenterY="118.07764390896921" Width="39.348058902275795" Height="20.0" ZOrder="32770" FontSize="10" Valign="Middle" Color="0000ff" />
     <Xref Database="HMDB" ID="HMDB0000464" />
   </DataNode>
   <DataNode TextLabel="Ca2+" GraphId="e0098" Type="Metabolite">
-    <Graphics CenterX="319.6740294511379" CenterY="299.0776439089692" Width="31.348058902275852" Height="20.0" ZOrder="32771" FontSize="10" Valign="Middle" Color="0000ff" />
+    <Graphics CenterX="311.34069611780444" CenterY="294.9109772423029" Width="31.348058902275852" Height="20.0" ZOrder="32771" FontSize="10" Valign="Middle" Color="0000ff" />
     <Xref Database="HMDB" ID="HMDB0000464" />
   </DataNode>
   <DataNode TextLabel="Ca2+" GraphId="c88ad" Type="Metabolite">
-    <Graphics CenterX="358.1740294511379" CenterY="312.0776439089692" Width="32.34805890227585" Height="20.0" ZOrder="32772" FontSize="10" Valign="Middle" Color="0000ff" />
+    <Graphics CenterX="356.5073627844713" CenterY="323.744310575636" Width="32.34805890227585" Height="20.0" ZOrder="32772" FontSize="10" Valign="Middle" Color="0000ff" />
     <Xref Database="HMDB" ID="HMDB0000464" />
   </DataNode>
   <DataNode TextLabel="Ca2+" GraphId="e6cfe" Type="Metabolite" GroupRef="a1d2b">
-    <Graphics CenterX="194.72444961920516" CenterY="334.0776439089692" Width="31.348058902275852" Height="20.0" ZOrder="32773" FontSize="10" Valign="Middle" Color="0000ff" />
+    <Graphics CenterX="178.0577829525385" CenterY="336.57764390896995" Width="31.348058902275852" Height="20.0" ZOrder="32773" FontSize="10" Valign="Middle" Color="0000ff" />
     <Xref Database="HMDB" ID="HMDB0000464" />
   </DataNode>
   <DataNode TextLabel="Ca2+" GraphId="f2ede" Type="Metabolite" GroupRef="a1d2b">
-    <Graphics CenterX="208.22444961920516" CenterY="365.0776439089692" Width="32.34805890227585" Height="20.0" ZOrder="32774" FontSize="10" Valign="Middle" Color="0000ff" />
+    <Graphics CenterX="211.55778295253853" CenterY="370.9109772423028" Width="32.34805890227585" Height="20.0" ZOrder="32774" FontSize="10" Valign="Middle" Color="0000ff" />
     <Xref Database="HMDB" ID="HMDB0000464" />
   </DataNode>
   <DataNode TextLabel="FAK" GraphId="e2883" Type="GeneProduct">
@@ -123,15 +123,15 @@ Proteins on this pathway have targeted assays available via the [https://assays.
     <Xref Database="Ensembl" ID="ENSG00000100030" />
   </DataNode>
   <DataNode TextLabel="Ca2+" GraphId="b6202" Type="Metabolite" GroupRef="a1d2b">
-    <Graphics CenterX="139.72444961920516" CenterY="360.0776439089692" Width="31.348058902275852" Height="20.0" ZOrder="32799" FontSize="10" Valign="Middle" Color="0000ff" />
+    <Graphics CenterX="144.72444961920513" CenterY="354.244310575636" Width="31.348058902275852" Height="20.0" ZOrder="32799" FontSize="10" Valign="Middle" Color="0000ff" />
     <Xref Database="HMDB" ID="HMDB0000464" />
   </DataNode>
   <DataNode TextLabel="Ca2+" GraphId="a1e68" Type="Metabolite" GroupRef="a1d2b">
-    <Graphics CenterX="163.72444961920516" CenterY="390.0776439089692" Width="31.348058902275852" Height="20.0" ZOrder="32800" FontSize="10" Valign="Middle" Color="0000ff" />
+    <Graphics CenterX="168.72444961920522" CenterY="384.244310575636" Width="31.348058902275852" Height="20.0" ZOrder="32800" FontSize="10" Valign="Middle" Color="0000ff" />
     <Xref Database="HMDB" ID="HMDB0000464" />
   </DataNode>
   <DataNode TextLabel="JUN" GraphId="c4843" Type="GeneProduct">
-    <Graphics CenterX="207.68067226890747" CenterY="598.5966386554612" Width="42.0" Height="20.0" ZOrder="32802" FontSize="10" Valign="Middle" />
+    <Graphics CenterX="213.51400560224087" CenterY="597.7633053221278" Width="42.0" Height="20.0" ZOrder="32802" FontSize="10" Valign="Middle" />
     <Xref Database="Ensembl" ID="ENSG00000177606" />
   </DataNode>
   <DataNode TextLabel="ERK1" GraphId="ab54f" Type="GeneProduct" GroupRef="f6235">
@@ -147,332 +147,329 @@ Proteins on this pathway have targeted assays available via the [https://assays.
     <Xref Database="" ID="" />
   </State>
   <State GraphRef="f4e1e" TextLabel="P" GraphId="eefb8">
-    <Graphics RelX="1.0" RelY="-1.0" Width="15.0" Height="15.0" ShapeType="Oval" />
+    <Graphics RelX="1.0" RelY="-0.9166666666666629" Width="15.0" Height="15.0" ShapeType="Oval" />
     <Xref Database="" ID="" />
   </State>
   <State GraphRef="e2883" TextLabel="P" GraphId="f3ae2">
-    <Comment>parentid=Q05397; parentsymbol=FAK; site=PIGNQHIyQPVGKPD; position=tyr861; ptm=p; direction=u; sitegrpid=447965</Comment>
+    <Comment>parent=Q05397; parentsymbol=FAK; site=PIGNQHIyQPVGKPD; position=tyr861; sitegrpid=447965; ptm=p; direction=u</Comment>
     <Graphics RelX="0.9568619524730748" RelY="-0.9" Width="15.0" Height="15.0" ShapeType="Oval" />
-    <Xref Database="phosphositeplus" ID="447965" />
+    <Xref Database="" ID="" />
   </State>
   <State GraphRef="be7bf" TextLabel="P" GraphId="f3c0a">
-    <Comment>parentid=Q04759; parentsymbol=PRKCQ; site=LGDAktNtFCGtPDy; position=thr538; ptm=p; direction=u; sitegrpid=447907</Comment>
+    <Comment>parent=Q04759; parentsymbol=PRKCQ; site=LGDAktNtFCGtPDy; position=thr538; sitegrpid=447907; ptm=p; direction=u</Comment>
     <Graphics RelX="1.0" RelY="1.0" Width="15.0" Height="15.0" ShapeType="Oval" />
-    <Xref Database="phosphositeplus" ID="447907" />
+    <Xref Database="" ID="" />
   </State>
   <State GraphRef="a6bf7" TextLabel="P" GraphId="f3ff8">
-    <Comment>parentid=P19174; parentsymbol=PLCG1; site=EGRNPGFyVEANPMP; position=tyr783; ptm=p; direction=u; sitegrpid=447667</Comment>
+    <Comment>parent=P19174; parentsymbol=PLCG1; site=EGRNPGFyVEANPMP; position=tyr783; sitegrpid=447667; ptm=p; direction=u</Comment>
     <Graphics RelX="1.0" RelY="-1.0" Width="15.0" Height="15.0" ShapeType="Oval" />
-    <Xref Database="phosphositeplus" ID="447667" />
+    <Xref Database="" ID="" />
   </State>
   <State GraphRef="e2f2e" TextLabel="P" GraphId="a681f">
     <Graphics RelX="1.0" RelY="-1.0" Width="15.0" Height="15.0" ShapeType="Oval" />
     <Xref Database="" ID="" />
   </State>
   <State GraphRef="a58a5" TextLabel="P" GraphId="a3ac3">
-    <Comment>parentid=P27361; parentsymbol=MAPK3; site=HtGFLtEyVAtRWyr; position=tyr204; ptm=p; direction=u; sitegrpid=447543</Comment>
+    <Comment>parent=P27361; parentsymbol=MAPK3; site=HtGFLtEyVAtRWyr; position=tyr204; sitegrpid=447543; ptm=p; direction=u</Comment>
     <Graphics RelX="1.0" RelY="1.0" Width="15.0" Height="15.0" ShapeType="Oval" />
-    <Xref Database="phosphositeplus" ID="447543" />
+    <Xref Database="" ID="" />
   </State>
   <State GraphRef="a58a5" TextLabel="P" GraphId="d1b1f">
-    <Comment>parentid=P27361; parentsymbol=MAPK3; site=HDHtGFLtEyVAtRW; position=thr202; ptm=p; direction=u; sitegrpid=447542</Comment>
+    <Comment>parent=P27361; parentsymbol=MAPK3; site=HDHtGFLtEyVAtRW; position=thr202; sitegrpid=447542; ptm=p; direction=u</Comment>
     <Graphics RelX="1.0" RelY="-0.6806722689075684" Width="15.0" Height="15.0" ShapeType="Oval" />
-    <Xref Database="phosphositeplus" ID="447542" />
+    <Xref Database="" ID="" />
   </State>
   <Interaction GraphId="id13d59668">
     <Graphics ZOrder="12288" LineThickness="1.0">
-      <Point GraphId="dd47f" X="119.44957983193278" Y="457.58823529411785" GraphRef="a9c7c" RelX="0.0" RelY="1.0" />
-      <Point GraphId="a46d3" X="119.57142857142857" Y="484.0" GraphRef="c2d99" RelX="0.0" RelY="0.0" ArrowHead="Arrow" />
+      <Point X="119.44957983193278" Y="457.5882352941178" GraphRef="fe0f2" RelX="0.0" RelY="1.0" />
+      <Point X="119.57142857142857" Y="484.0" GraphRef="c2d99" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="id28d25d56">
     <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
-      <Point GraphId="a7ac4" X="539.5" Y="381.0" GraphRef="b67fb" RelX="0.0" RelY="1.0" />
-      <Point GraphId="c0c29" X="414.625" Y="469.0" />
-      <Point GraphId="b3143" X="289.75" Y="345.0" GraphRef="ef707" RelX="-0.5" RelY="1.0" ArrowHead="Arrow" />
+      <Point X="539.5" Y="381.0" GraphRef="b67fb" RelX="0.0" RelY="1.0" />
+      <Point X="416.29166666666663" Y="469.0" />
+      <Point X="293.0833333333333" Y="351.6666666666666" GraphRef="ef707" RelX="-0.5" RelY="1.0" ArrowHead="Arrow" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="id2b5402f4">
     <Graphics ZOrder="12288" LineThickness="1.0">
-      <Point GraphId="e2199" X="146.0" Y="598.0" GraphRef="ad16b" RelX="1.0" RelY="0.0" />
-      <Point GraphId="c76ed" X="186.68067226890747" Y="598.5966386554612" GraphRef="c4843" RelX="-1.0" RelY="0.0" ArrowHead="mim-transcription-translation" />
+      <Point X="146.0" Y="598.0" GraphRef="ce904" RelX="1.0" RelY="0.0" />
+      <Point X="192.51400560224087" Y="597.7633053221278" GraphRef="c4843" RelX="-1.0" RelY="0.0" ArrowHead="mim-transcription-translation" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="id2bbeb774">
     <Graphics ZOrder="12288" LineThickness="1.0">
-      <Point GraphId="c9604" X="342.0" Y="312.0776439089692" GraphRef="c88ad" RelX="-1.0" RelY="0.0" />
-      <Point GraphId="a29d3" X="224.3984790703431" Y="365.0776439089692" GraphRef="f2ede" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
+      <Point X="340.33333333333337" Y="323.744310575636" GraphRef="c88ad" RelX="-1.0" RelY="0.0" />
+      <Point X="227.73181240367646" Y="370.9109772423028" GraphRef="f2ede" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
       <Anchor Position="0.4" Shape="None" GraphId="ee2df" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="id374db26e">
     <Graphics ZOrder="12288" LineThickness="1.0">
-      <Point GraphId="e9015" X="82.59663865546233" Y="167.5987394957984" GraphRef="a0015" RelX="-1.0" RelY="-0.5" />
-      <Point GraphId="a42a0" X="157.6941975183648" Y="184.0776439089692" GraphRef="f2e5f" RelX="0.0" RelY="0.0" />
+      <Point X="82.5966386554623" Y="170.9320728291316" GraphRef="a0015" RelX="-1.0" RelY="-0.5" />
+      <Point X="164.34069611780453" Y="181.74431057563592" GraphRef="f2e5f" RelX="0.0" RelY="0.0" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="id38cf5c8b">
     <Graphics ZOrder="12288" LineThickness="1.0">
-      <Point GraphId="f9191" X="294.9593916281372" Y="333.2776439089692" GraphRef="ee2df" RelX="0.0" RelY="0.0" />
-      <Point GraphId="ccf2e" X="300.5" Y="325.0" GraphRef="ef707" RelX="0.0" RelY="-1.0" />
+      <Point X="295.2927249614706" Y="342.61097724230274" GraphRef="ee2df" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
+      <Point X="303.8333333333333" Y="331.6666666666666" GraphRef="ef707" RelX="0.0" RelY="-1.0" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="id4a2a2780">
     <Graphics ZOrder="12288" LineThickness="1.0">
-      <Point GraphId="b3f72" X="838.0" Y="52.0" GraphRef="bf659" RelX="0.0" RelY="1.0" />
-      <Point GraphId="eea5e" X="837.2869292295234" Y="94.91298527443104" GraphRef="b7eea" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
+      <Point X="838.0" Y="63.666666666666686" GraphRef="bf659" RelX="0.0" RelY="1.0" />
+      <Point X="838.1202625628569" Y="94.91298527443104" GraphRef="b7eea" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="id55bc24bb">
     <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
-      <Point GraphId="dc13a" X="683.0" Y="349.0" GraphRef="d1e91" RelX="1.0" RelY="0.0" />
-      <Point GraphId="e1fd9" X="771.0" Y="295.5" />
-      <Point GraphId="dbbfa" X="696.0" Y="242.0" GraphRef="ed09d" RelX="0.0" RelY="0.0" ArrowHead="Arrow" />
+      <Point X="683.0" Y="349.0" GraphRef="d1e91" RelX="1.0" RelY="0.0" />
+      <Point X="771.0" Y="295.5" />
+      <Point X="696.0" Y="242.0" GraphRef="ed09d" RelX="0.0" RelY="0.0" ArrowHead="Arrow" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="id5d3b9009">
     <Graphics ZOrder="12288" LineThickness="1.0">
-      <Point GraphId="ae187" X="837.2869292295234" Y="114.91298527443104" GraphRef="b7eea" RelX="0.0" RelY="1.0" />
-      <Point GraphId="f1b12" X="838.0" Y="151.0" GraphRef="b680b" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
+      <Point X="838.1202625628569" Y="114.91298527443104" GraphRef="b7eea" RelX="0.0" RelY="1.0" />
+      <Point X="838.0" Y="151.0" GraphRef="d046d" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="id61312efe">
     <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0">
-      <Point GraphId="ca8e3" X="228.68067226890747" Y="598.5966386554612" GraphRef="c4843" RelX="1.0" RelY="0.0" />
-      <Point GraphId="f2d46" X="342.0" Y="598.0" GraphRef="b1e44" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
+      <Point X="234.51400560224087" Y="597.7633053221278" GraphRef="c4843" RelX="1.0" RelY="0.0" />
+      <Point X="342.0" Y="598.0" GraphRef="e0815" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="id621b501">
     <Graphics ZOrder="12288" LineThickness="1.0">
-      <Point GraphId="cc8b0" X="869.0" Y="242.05890227576975" GraphRef="e0e26" RelX="-1.0" RelY="0.0" />
-      <Point GraphId="d0342" X="790.3627844712182" Y="242.05890227576975" GraphRef="e2883" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
+      <Point X="869.0" Y="242.05890227576975" GraphRef="e0e26" RelX="-1.0" RelY="0.0" />
+      <Point X="790.3627844712182" Y="242.05890227576975" GraphRef="e2883" RelX="1.0" RelY="0.0" ArrowHead="mim-modification" />
       <Anchor Position="0.4" Shape="None" GraphId="fdccb" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="id6c8bfc4e">
     <Graphics ZOrder="12288" LineThickness="1.0">
-      <Point GraphId="ff3a0" X="157.6740294511379" Y="128.0776439089692" GraphRef="aa064" RelX="0.0" RelY="1.0" />
-      <Point GraphId="ae364" X="157.72444961920516" Y="268.0776439089692" GraphRef="a042e" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
+      <Point X="164.34069611780453" Y="128.0776439089692" GraphRef="aa064" RelX="0.0" RelY="1.0" />
+      <Point X="164.3406961178045" Y="262.244310575636" GraphRef="a042e" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
       <Anchor Position="0.4" Shape="None" GraphId="f2e5f" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="id70471342">
     <Graphics ZOrder="12288" LineThickness="1.0">
-      <Point GraphId="e867a" X="539.0" Y="299.0" GraphRef="d312e" RelX="0.0" RelY="1.0" />
-      <Point GraphId="a1efe" X="539.5" Y="361.0" GraphRef="b67fb" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
+      <Point X="539.0" Y="299.0" GraphRef="d312e" RelX="0.0" RelY="1.0" />
+      <Point X="539.5" Y="361.0" GraphRef="b67fb" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
       <Anchor Position="0.2256617025427585" Shape="None" GraphId="bd964" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="id74e9738">
     <Graphics ZOrder="12288" LineThickness="1.0">
-      <Point GraphId="e41bb" X="195.9999999999999" Y="428.9915966386559" GraphRef="f6235" RelX="-1.0" RelY="0.0" />
-      <Point GraphId="b480a" X="150.9495798319328" Y="429.5882352941178" GraphRef="a9c7c" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
+      <Point X="195.99999999999991" Y="428.9915966386559" GraphRef="c981f" RelX="-1.0" RelY="0.0" />
+      <Point X="150.9495798319328" Y="429.5882352941178" GraphRef="fe0f2" RelX="1.0" RelY="0.0" ArrowHead="mim-modification" />
       <Anchor Position="0.4002399040383847" Shape="None" GraphId="bffcd" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="id75df666f">
     <Graphics ZOrder="12288" LineThickness="1.0">
-      <Point GraphId="fbeed" X="269.0" Y="318.0" GraphRef="c59d3" RelX="0.0" RelY="1.0" />
-      <Point GraphId="d3343" X="266.55939162813723" Y="313.0776439089692" GraphRef="ef620" RelX="0.0" RelY="0.0" />
+      <Point X="266.5000000000008" Y="319.6666666666664" GraphRef="c59d3" RelX="0.0" RelY="1.0" />
+      <Point X="267.8314214993387" Y="306.2888507906354" GraphRef="ef620" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="id84a1bc0f">
     <Graphics ZOrder="12288" LineThickness="1.0">
-      <Point GraphId="e39e2" X="583.0" Y="313.0" GraphRef="a6bf7" RelX="-1.0" RelY="0.0" />
-      <Point GraphId="dbbca" X="539.1128308512714" Y="312.991025557651" GraphRef="bd964" RelX="0.0" RelY="0.0" ArrowHead="Arrow" />
+      <Point X="583.0" Y="313.0" GraphRef="a6bf7" RelX="-1.0" RelY="0.0" />
+      <Point X="539.1128308512714" Y="312.991025557651" GraphRef="bd964" RelX="0.0" RelY="0.0" ArrowHead="Arrow" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="id8e8c77ca">
     <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0">
-      <Point GraphId="b4368" X="539.747899159663" Y="598.7394957983191" GraphRef="c359a" RelX="1.0" RelY="0.0" />
-      <Point GraphId="a233b" X="581.6302521008403" Y="447.94117647058846" GraphRef="a7bcb" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
+      <Point X="539.747899159663" Y="597.9061624649858" GraphRef="c359a" RelX="1.0" RelY="0.0" />
+      <Point X="603.296918767507" Y="447.94117647058846" GraphRef="a7bcb" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="id966d3807">
-    <Graphics ZOrder="12288" LineThickness="1.0">
-      <Point GraphId="cce88" X="835.0" Y="448.0" GraphRef="b25b4" RelX="1.0" RelY="0.0" />
-      <Point GraphId="e2dc9" X="861.0" Y="423.0" GraphRef="adf1d" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
+    <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0">
+      <Point X="835.0" Y="448.0" GraphRef="e7e86" RelX="1.0" RelY="0.0" />
+      <Point X="872.6666666666664" Y="423.0" GraphRef="adf1d" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="id999a4c0e">
     <Graphics ConnectorType="Curved" ZOrder="12288" LineThickness="1.0">
-      <Point GraphId="f2239" X="539.1128308512714" Y="312.991025557651" GraphRef="bd964" RelX="0.0" RelY="0.0" />
-      <Point GraphId="f0997" X="549.0" Y="335.2" />
-      <Point GraphId="a7fa0" X="639.0" Y="349.0" GraphRef="d1e91" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
+      <Point X="539.1128308512714" Y="312.991025557651" GraphRef="bd964" RelX="0.0" RelY="0.0" />
+      <Point X="549.0" Y="335.2" />
+      <Point X="639.0" Y="349.0" GraphRef="d1e91" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="ida20212b4">
     <Graphics ZOrder="12288" LineThickness="1.0">
-      <Point GraphId="b43b3" X="838.0" Y="195.0" GraphRef="b680b" RelX="0.0" RelY="1.0" />
-      <Point GraphId="d0ae3" X="837.5451137884872" Y="242.05890227576975" GraphRef="fdccb" RelX="0.0" RelY="0.0" ArrowHead="Arrow" />
+      <Point X="838.0" Y="195.0" GraphRef="d046d" RelX="0.0" RelY="1.0" />
+      <Point X="837.5451137884872" Y="242.05890227576975" GraphRef="fdccb" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="idabbb9f63">
     <Graphics ZOrder="12288" LineThickness="1.0">
-      <Point GraphId="d0cb4" X="744.0" Y="242.05890227576975" GraphRef="e2883" RelX="-1.0" RelY="0.0" />
-      <Point GraphId="dcff5" X="696.0" Y="242.0" GraphRef="ed09d" RelX="0.0" RelY="0.0" ArrowHead="Arrow" />
+      <Point X="744.0" Y="242.05890227576975" GraphRef="e2883" RelX="-1.0" RelY="0.0" />
+      <Point X="696.0" Y="242.0" GraphRef="ed09d" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="idc053788d">
     <Graphics ZOrder="12288" LineThickness="1.0">
-      <Point GraphId="d5c31" X="648.6302521008403" Y="447.94117647058846" GraphRef="a7bcb" RelX="1.0" RelY="0.0" />
-      <Point GraphId="edc43" X="732.0" Y="448.0" GraphRef="b25b4" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
+      <Point X="670.296918767507" Y="447.94117647058846" GraphRef="a7bcb" RelX="1.0" RelY="0.0" />
+      <Point X="732.0" Y="448.0" GraphRef="e7e86" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="idc1572cc8">
     <Graphics ZOrder="12288" LineThickness="1.0">
-      <Point GraphId="ced64" X="696.0" Y="224.0" GraphRef="eb343" RelX="0.0" RelY="1.0" />
-      <Point GraphId="f30dd" X="696.0" Y="269.0" GraphRef="be7bf" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
+      <Point X="696.0" Y="224.0" GraphRef="eb343" RelX="0.0" RelY="1.0" />
+      <Point X="696.0" Y="269.0" GraphRef="be7bf" RelX="0.0" RelY="-1.0" ArrowHead="mim-modification" />
       <Anchor Position="0.4" Shape="None" GraphId="ed09d" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="idc618f2ed">
-    <Graphics ZOrder="12288" LineThickness="1.0">
-      <Point GraphId="fdbf0" X="174.22444961920516" Y="408.0776439089692" GraphRef="a1d2b" RelX="0.0" RelY="1.0" />
-      <Point GraphId="d8889" X="177.9690241550438" Y="429.23039523686356" GraphRef="bffcd" RelX="0.0" RelY="0.0" ArrowHead="Arrow" />
+    <Graphics ZOrder="12288" LineStyle="Broken" LineThickness="1.0">
+      <Point X="178.39111628587182" Y="402.244310575636" GraphRef="b2dde" RelX="0.0" RelY="1.0" />
+      <Point X="177.96902415504383" Y="429.23039523686356" GraphRef="bffcd" RelX="0.0" RelY="0.0" ArrowHead="Arrow" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="idc84e958d">
     <Graphics ZOrder="12288" LineThickness="1.0">
-      <Point GraphId="e4600" X="304.0" Y="299.0776439089692" GraphRef="e0098" RelX="-1.0" RelY="0.0" />
-      <Point GraphId="aeddf" X="210.3984790703431" Y="334.0776439089692" GraphRef="e6cfe" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
-      <Anchor Position="0.4" Shape="None" GraphId="ef620" />
+      <Point X="295.6666666666665" Y="294.9109772423029" GraphRef="e0098" RelX="-1.0" RelY="0.0" />
+      <Point X="193.73181240367643" Y="336.57764390896995" GraphRef="e6cfe" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
+      <Anchor Position="0.27306896515997753" Shape="None" GraphId="ef620" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="ide6c55a62">
     <Graphics ZOrder="12288" LineThickness="1.0">
-      <Point GraphId="d9b7d" X="66.0" Y="494.0" GraphRef="b1584" RelX="0.0" RelY="1.0" />
-      <Point GraphId="d3cb4" X="66.0" Y="587.0" GraphRef="e2f2e" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
+      <Point X="66.0" Y="494.0" GraphRef="b1584" RelX="0.0" RelY="1.0" />
+      <Point X="66.0" Y="587.0" GraphRef="e2f2e" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="ided51a0f5">
     <Graphics ZOrder="12288" LineThickness="1.0">
-      <Point GraphId="ca76d" X="144.0" Y="484.0" GraphRef="afc13" RelX="-1.0" RelY="0.0" />
-      <Point GraphId="f9c4d" X="87.0" Y="484.0" GraphRef="b1584" RelX="1.0" RelY="0.0" ArrowHead="Arrow" />
+      <Point X="144.0" Y="484.0" GraphRef="afc13" RelX="-1.0" RelY="0.0" />
+      <Point X="87.0" Y="484.0" GraphRef="b1584" RelX="1.0" RelY="0.0" ArrowHead="mim-modification" />
       <Anchor Position="0.42857142857142855" Shape="None" GraphId="c2d99" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="idf4e3c95">
     <Graphics ZOrder="12288" LineThickness="1.0">
-      <Point GraphId="b713e" X="607.0" Y="263.0" GraphRef="d266c" RelX="0.0" RelY="1.0" />
-      <Point GraphId="e3042" X="607.0" Y="303.0" GraphRef="a6bf7" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
+      <Point X="607.0" Y="263.0" GraphRef="d266c" RelX="0.0" RelY="1.0" />
+      <Point X="607.0" Y="303.0" GraphRef="a6bf7" RelX="0.0" RelY="-1.0" ArrowHead="mim-modification" />
       <Anchor Position="0.4" Shape="None" GraphId="c8dbb" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="idf953f670">
     <Graphics ZOrder="12288" LineThickness="1.0">
-      <Point GraphId="b0cc5" X="671.0" Y="279.0" GraphRef="be7bf" RelX="-1.0" RelY="0.0" />
-      <Point GraphId="acdbb" X="607.0" Y="279.0" GraphRef="c8dbb" RelX="0.0" RelY="0.0" ArrowHead="Arrow" />
+      <Point X="671.0" Y="279.0" GraphRef="be7bf" RelX="-1.0" RelY="0.0" />
+      <Point X="607.0" Y="279.0" GraphRef="c8dbb" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="e3478">
-    <Graphics ZOrder="32788" LineThickness="1.0">
-      <Point GraphId="c8e89" X="835.0" Y="448.0" GraphRef="b25b4" RelX="1.0" RelY="0.0" />
-      <Point GraphId="b0874" X="861.0" Y="469.0" GraphRef="d6592" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
+    <Graphics ZOrder="32788" LineStyle="Broken" LineThickness="1.0">
+      <Point X="835.0" Y="448.0" GraphRef="e7e86" RelX="1.0" RelY="0.0" />
+      <Point X="872.6666666666664" Y="469.0" GraphRef="d6592" RelX="-1.0" RelY="0.0" ArrowHead="Arrow" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <Interaction GraphId="e3382">
     <Graphics ZOrder="32803" LineThickness="1.0">
-      <Point GraphId="d7444" X="451.0" Y="598.0" GraphRef="b1e44" RelX="1.0" RelY="0.0" />
-      <Point GraphId="a4e19" X="484.2436974789906" Y="598.7394957983191" GraphRef="c359a" RelX="-1.0" RelY="0.0" ArrowHead="mim-transcription-translation" />
+      <Point X="451.0" Y="598.0" GraphRef="e0815" RelX="1.0" RelY="0.0" />
+      <Point X="484.2436974789906" Y="597.9061624649858" GraphRef="c359a" RelX="-1.0" RelY="0.0" ArrowHead="mim-transcription-translation" />
     </Graphics>
     <Xref Database="" ID="" />
   </Interaction>
   <GraphicalLine GraphId="idbf9ce4fa" GroupRef="b25b4">
     <Graphics ZOrder="12288" LineThickness="1.0" Color="009999">
-      <Point GraphId="d437e" X="751.0" Y="421.0" />
-      <Point GraphId="df802" X="781.0" Y="451.0" />
+      <Point X="751.0" Y="421.0" />
+      <Point X="781.0" Y="451.0" />
     </Graphics>
   </GraphicalLine>
   <GraphicalLine GraphId="c9709" GroupRef="b25b4">
     <Graphics ZOrder="32783" LineThickness="1.0" Color="009999">
-      <Point GraphId="c3b73" X="823.0" Y="422.0" />
-      <Point GraphId="cf783" X="784.0" Y="467.0" />
+      <Point X="823.0" Y="422.0" />
+      <Point X="784.0" Y="467.0" />
     </Graphics>
   </GraphicalLine>
   <GraphicalLine GraphId="b7f00" GroupRef="b25b4">
     <Graphics ZOrder="32784" LineThickness="1.0" Color="009999">
-      <Point GraphId="d6ac8" X="740.0" Y="449.0" />
-      <Point GraphId="fd568" X="792.0" Y="475.0" />
+      <Point X="740.0" Y="449.0" />
+      <Point X="792.0" Y="475.0" />
     </Graphics>
   </GraphicalLine>
   <GraphicalLine GraphId="e4008" GroupRef="b25b4">
     <Graphics ZOrder="32785" LineThickness="1.0" Color="009999">
-      <Point GraphId="eb4ad" X="772.0" Y="438.0" />
-      <Point GraphId="c241d" X="827.0" Y="442.0" />
+      <Point X="772.0" Y="438.0" />
+      <Point X="827.0" Y="442.0" />
     </Graphics>
   </GraphicalLine>
   <GraphicalLine GraphId="a127b" GroupRef="b25b4">
     <Graphics ZOrder="32786" LineThickness="1.0" Color="009999">
-      <Point GraphId="ce0d1" X="750.0" Y="436.0" />
-      <Point GraphId="cc996" X="805.0" Y="468.0" />
+      <Point X="750.0" Y="436.0" />
+      <Point X="805.0" Y="468.0" />
     </Graphics>
   </GraphicalLine>
   <Label TextLabel="Calcium selective/non-selective&#xA;cation channel" GraphId="a0015">
-    <Graphics CenterX="158.09663865546233" CenterY="174.3487394957984" Width="151.0" Height="27.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" />
+    <Graphics CenterX="158.0966386554623" CenterY="177.6820728291316" Width="151.0" Height="27.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" ShapeType="Rectangle" />
   </Label>
   <Label TextLabel="Increase cell &#xA;motility" GraphId="adf1d">
-    <Graphics CenterX="905.0" CenterY="423.0" Width="88.0" Height="24.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
+    <Graphics CenterX="916.6666666666664" CenterY="423.0" Width="88.0" Height="24.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
   </Label>
   <Label TextLabel="Activated JUN forms transcription &#xA;complex with cofactor" GraphId="b15b5">
-    <Graphics CenterX="295.0" CenterY="634.0" Width="164.0" Height="24.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="10" Valign="Middle" />
+    <Graphics CenterX="287.2499999999999" CenterY="640.6666666666669" Width="207.83333333333331" Height="24.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
   </Label>
   <Label TextLabel="Cofactor" GraphId="cf4d1" GroupRef="b1e44">
     <Graphics CenterX="414.5" CenterY="599.0" Width="57.0" Height="20.0" ZOrder="28672" FillColor="cccccc" FontSize="10" Valign="Middle" ShapeType="Oval" />
   </Label>
   <Label TextLabel="Increase traction &#xA;force" GraphId="d6592">
-    <Graphics CenterX="916.0" CenterY="469.0" Width="110.0" Height="28.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
+    <Graphics CenterX="927.6666666666664" CenterY="469.0" Width="110.0" Height="28.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
   </Label>
   <Label TextLabel="Troponin C interacts &#xA;with F-actin" GraphId="d7385">
-    <Graphics CenterX="695.0" CenterY="413.0" Width="106.0" Height="30.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="10" Valign="Middle" />
+    <Graphics CenterX="693.999999999998" CenterY="481.33333333333354" Width="137.9999999999999" Height="30.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
   </Label>
   <Label TextLabel="Transcription of Troponin C" GraphId="dfee2">
     <Graphics CenterX="422.0" CenterY="567.0" Width="136.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="10" Valign="Middle" />
   </Label>
-  <Label TextLabel="Ovarian Cancer Cell" GraphId="f47d4">
-    <Graphics CenterX="479.5" CenterY="191.0" Width="137.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
-  </Label>
   <Label TextLabel="Extracellular calcium source" GraphId="f9567">
-    <Graphics CenterX="150.0" CenterY="77.0" Width="172.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
+    <Graphics CenterX="167.49999999999972" CenterY="86.99999999999994" Width="172.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
   </Label>
   <Label TextLabel="Cancer-associated stromal fibroblasts&#xA;(CAFs)" GraphId="bf659">
-    <Graphics CenterX="838.0" CenterY="32.0" Width="246.0" Height="40.0" ZOrder="32769" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
+    <Graphics CenterX="838.0" CenterY="43.666666666666686" Width="246.0" Height="40.0" ZOrder="32769" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
   </Label>
   <Label TextLabel="ER" GraphId="f661d">
     <Graphics CenterX="300.0" CenterY="242.0" Width="34.0" Height="20.0" ZOrder="32775" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
   </Label>
   <Label TextLabel="Increased cytoplasmic&#xA;Ca2+ concentration" GraphId="bdc63">
-    <Graphics CenterX="109.0" CenterY="320.5" Width="148.0" Height="27.0" ZOrder="32776" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
+    <Graphics CenterX="99.0" CenterY="313.8333333333335" Width="148.0" Height="27.0" ZOrder="32776" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
   </Label>
   <Label TextLabel="Cofactor" GraphId="a937f" GroupRef="ad16b">
     <Graphics CenterX="109.5" CenterY="599.0" Width="57.0" Height="20.0" ZOrder="32792" FillColor="cccccc" FontSize="10" Valign="Middle" ShapeType="Oval" />
@@ -482,47 +479,28 @@ Proteins on this pathway have targeted assays available via the [https://assays.
   </Label>
   <Shape GraphId="aba9a">
     <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Endoplasmic Reticulum" />
-    <Graphics CenterX="358.89219101761563" CenterY="291.15478475817355" Width="256.0" Height="215.24468093154042" ZOrder="16384" FillColor="edeaea" FontSize="10" Valign="Middle" ShapeType="Endoplasmic Reticulum" LineThickness="2.0" Color="c0c0c0" Rotation="0.6968727446734324" />
+    <Graphics CenterX="358.89219101761563" CenterY="291.15478475817355" Width="256.0" Height="215.24468093154042" ZOrder="-2" FillColor="edeaea" FontSize="10" Valign="Middle" ShapeType="Endoplasmic Reticulum" LineThickness="2.0" Color="c0c0c0" Rotation="0.6968727446734324" />
   </Shape>
   <Shape GraphId="ef470">
     <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Nucleus" />
     <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" />
-    <Graphics CenterX="361.0" CenterY="584.0" Width="668.0" Height="150.0" ZOrder="16384" FontWeight="Bold" FontSize="10" Valign="Middle" ShapeType="Oval" LineThickness="3.0" Color="c0c0c0" Rotation="0.0" />
+    <Graphics CenterX="361.0" CenterY="587.0000000000003" Width="668.0" Height="169.3333333333328" ZOrder="16384" FontWeight="Bold" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" LineThickness="3.0" Color="c0c0c0" Rotation="0.0" />
   </Shape>
-  <Shape GraphId="f85d7">
+  <Shape TextLabel="Ovarian Cancer Cell" GraphId="f85d7">
     <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Cell" />
     <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" />
-    <Graphics CenterX="495.5" CenterY="445.5" Width="977.0" Height="535.0" ZOrder="16384" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" LineThickness="3.0" Color="c0c0c0" Rotation="0.0" />
+    <Graphics CenterX="495.5" CenterY="437.75" Width="977.0" Height="519.5" ZOrder="16384" FontSize="14" ShapeType="RoundedRectangle" LineThickness="3.0" Color="c0c0c0" Rotation="0.0" />
   </Shape>
-  <Group GroupId="a1d2b" GraphId="a1d2b" Style="Group" />
-  <Group GroupId="f6235" GraphId="f6235" Style="Group" />
-  <Group GroupId="ad16b" GraphId="ad16b" Style="Group" />
-  <Group GroupId="b680b" GraphId="b680b" Style="Complex" />
-  <Group GroupId="b1e44" GraphId="b1e44" Style="Group" />
-  <Group GroupId="b25b4" GraphId="b25b4" Style="Group" />
-  <Group GroupId="a9c7c" GraphId="a9c7c" Style="Group" />
+  <Group GroupId="a1d2b" GraphId="b2dde" Style="Group" />
+  <Group GroupId="f6235" GraphId="c981f" Style="Group" />
+  <Group GroupId="ad16b" GraphId="ce904" Style="Group" />
+  <Group GroupId="b680b" GraphId="d046d" Style="Complex" />
+  <Group GroupId="b1e44" GraphId="e0815" Style="Group" />
+  <Group GroupId="b25b4" GraphId="e7e86" Style="Group" />
+  <Group GroupId="d348f" GraphId="f3b2d" Style="Group" />
+  <Group GroupId="a9c7c" GraphId="fe0f2" Style="Group" />
   <InfoBox CenterX="0.0" CenterY="0.0" />
   <Biopax>
-    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
-      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ovarian cancer</bp:TERM>
-      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:2394</bp:ID>
-      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Human Disease Ontology</bp:Ontology>
-    </bp:openControlledVocabulary>
-    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
-      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">disease pathway</bp:TERM>
-      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000013</bp:ID>
-      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
-    </bp:openControlledVocabulary>
-    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
-      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cancer pathway</bp:TERM>
-      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000605</bp:ID>
-      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
-    </bp:openControlledVocabulary>
-    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
-      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">disease of cellular proliferation</bp:TERM>
-      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:14566</bp:ID>
-      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Human Disease Ontology</bp:Ontology>
-    </bp:openControlledVocabulary>
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a0f">
       <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">25277212</bp:ID>
       <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB>
@@ -543,5 +521,26 @@ Proteins on this pathway have targeted assays available via the [https://assays.
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Birrer MJ</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mok SC</bp:AUTHORS>
     </bp:PublicationXref>
+    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
+      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">disease pathway</bp:TERM>
+      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000013</bp:ID>
+      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
+    </bp:openControlledVocabulary>
+    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
+      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ovarian cancer</bp:TERM>
+      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:2394</bp:ID>
+      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology>
+    </bp:openControlledVocabulary>
+    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
+      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cancer pathway</bp:TERM>
+      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000605</bp:ID>
+      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
+    </bp:openControlledVocabulary>
+    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
+      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">disease of cellular proliferation</bp:TERM>
+      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:14566</bp:ID>
+      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology>
+    </bp:openControlledVocabulary>
   </Biopax>
 </Pathway>
+