From 6bcbf92f1bf14ee0e4299f45fa9948c9c4e8a66e Mon Sep 17 00:00:00 2001 From: Alexander Pico Date: Sat, 4 Nov 2023 13:56:07 -0700 Subject: [PATCH 1/3] Create WP0001.gpml --- pathways/WP0001/WP0001.gpml | 363 ++++++++++++++++++++++++++++++++++++ 1 file changed, 363 insertions(+) create mode 100644 pathways/WP0001/WP0001.gpml diff --git a/pathways/WP0001/WP0001.gpml b/pathways/WP0001/WP0001.gpml new file mode 100644 index 00000000..3e6e708e --- /dev/null +++ b/pathways/WP0001/WP0001.gpml @@ -0,0 +1,363 @@ + + + Vitamin A5/X pathway which shows how our food results in precursors from which Vitamin A5/X (9CBC, 9CDHBC, 9CDHROL-ES and 9CDKHROL) is metabolized which is converted into Vitamin A5/X acid (9CDHRA) which binds to RXR. + cc4 + + + provitamin A1 + + + + + + + + + + + + + cc4 + + + + + + + + + + + + + + + + + + + + + + + + + vitamin A5/X acid + Both R and S forms bind, but R better. The R stereoisomer is patented + aab + + + + + + + + + + + + + vitamin A1 acid + + + + + vitamin A1 aldehyde + + + + + vitamin A1 + + + + + vitamin A1 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + cc4 + aab + ac9 + + + + + + + + + + + + + + + Multistep + cc4 + + + + + + + + + + + + + + + multistep + + + + + + + + + + + + + + + Multistep + cc4 + + + + + + + + + + + + + + + cc4 + + + + + + + + Multistep + cc4 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + multistep + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + aab + + + + + + + metabolic pathway of cofactors, vitamins, nutrients + PW:0000135 + Pathway Ontology + + + 10.1002/cmdc.201600105 + DOI + An Endogenous Mammalian Retinoid X Receptor Ligand, At Last! + ChemMedChem + 2016 + de Lera, A.R. + Krezel, W. + Ruehl, R. + + + 26030625 + PubMed + 9-cis-13,14-Dihydroretinoic Acid Is an Endogenous Retinoid Acting as RXR Ligand in Mice. + PLoS Genet + 2015 + Rühl R + Krzyżosiak A + Niewiadomska-Cimicka A + Rochel N + Szeles L + Vaz B + Wietrzych-Schindler M + Álvarez S + Szklenar M + Nagy L + de Lera AR + Krężel W + + + 33809241 + PubMed + Vitamin A5/X, a New Food to Lipid Hormone Concept for a Nutritional Ligand to Control RXR-Mediated Signaling. + Nutrients + 2021 + Krężel W + Rivas A + Szklenar M + Ciancia M + Alvarez R + de Lera AR + Rühl R + + + retinol metabolic pathway + PW:0000141 + Pathway Ontology + + + vitamin A and metabolites signaling pathway + PW:0001116 + Pathway Ontology + + + + From 983397c450c5b47bdbbcd51a82aa58fac7470851 Mon Sep 17 00:00:00 2001 From: Alexander Pico Date: Mon, 13 Nov 2023 16:28:45 -0800 Subject: [PATCH 2/3] Version needs underscore-separated values for meta-data-action --- pathways/WP0001/WP0001.gpml | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/pathways/WP0001/WP0001.gpml b/pathways/WP0001/WP0001.gpml index 3e6e708e..11d2e888 100644 --- a/pathways/WP0001/WP0001.gpml +++ b/pathways/WP0001/WP0001.gpml @@ -1,5 +1,5 @@ - + Vitamin A5/X pathway which shows how our food results in precursors from which Vitamin A5/X (9CBC, 9CDHBC, 9CDHROL-ES and 9CDKHROL) is metabolized which is converted into Vitamin A5/X acid (9CDHRA) which binds to RXR. cc4 From a0f23065f125ce0ef60e5d7671d789d998e7fc8c Mon Sep 17 00:00:00 2001 From: Alexander Pico Date: Tue, 23 Jan 2024 15:14:14 -0800 Subject: [PATCH 3/3] Rename WP0001.gpml to AlexanderPico__Vitamin_A1_and_A5_X_pathwaysX pathways.gpml --- ...=> AlexanderPico__Vitamin_A1_and_A5_X_pathwaysX pathways.gpml} | 0 1 file changed, 0 insertions(+), 0 deletions(-) rename pathways/WP0001/{WP0001.gpml => AlexanderPico__Vitamin_A1_and_A5_X_pathwaysX pathways.gpml} (100%) diff --git a/pathways/WP0001/WP0001.gpml b/pathways/WP0001/AlexanderPico__Vitamin_A1_and_A5_X_pathwaysX pathways.gpml similarity index 100% rename from pathways/WP0001/WP0001.gpml rename to pathways/WP0001/AlexanderPico__Vitamin_A1_and_A5_X_pathwaysX pathways.gpml