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- "markdown": "---\ntitle: \"DCA for Quantifying the Additional Benefit of a New Marker by Emily Vertosick and Andrew Vickers\"\ndate: \"2022-10-02\"\ncategories: \n - Replications\n - Decision\n - Emily Vertosick\n - Andrew Vickers\n - gt\n - gtsummary\n - dcurves\n - rms\n - Hmisc\nimage: \"image.jpg\"\ndraft: true\n---\n\n\n\n\n## Additional Benefit of a New Marker\n\nPrediction Model might gain accuracy if you'll add more relevant features to existing models, but many times it's not obvious what is the additional value of additional feature and how to quantify it in terms of Decision Making. The post [Decision curve analysis for quantifying the additional benefit of a new marker](https://www.fharrell.com/post/addmarkerdca) by Emily Vertosick and Andrew Vickers show a simple example (the code presented here is almost identical to the original code presented in the link).\n\n## Preparing the Data\n\n### Loading the Data with Hmisc\n\n\n::: {.cell}\n\n```{.r .cell-code}\nlibrary(Hmisc)\nlibrary(dplyr)\nlibrary(tibble)\n\ngetHdata(acath)\nacath <- subset(acath, !is.na(choleste))\n```\n:::\n\n\n### Fitting Logistic Regressions with rms\n\n\n::: {.cell}\n\n```{.r .cell-code}\nlibrary(rms)\n\npre <- lrm(sigdz ~ rcs(age,4) * sex, data = acath)\npre_pred <- predict(pre, type='fitted')\n\npost <- lrm(sigdz ~ rcs(age,4) * sex + \n rcs(choleste,4) + rcs(age,4) %ia% rcs(choleste,4), data = acath)\npost_pred <- predict(post, type='fitted')\n\nacath_pred <- bind_cols(\n acath,\n pre_pred %>% enframe(name = NULL, value = \"pre\"),\n post_pred %>% enframe(name = NULL, value = \"post\")\n )\n```\n:::\n\n\n## Conventional Decision Curve\n\n::: panel-tabset\n### dcurves\n\n::: {layout-ncol=\"2\"}\n\n::: {.cell}\n\n```{.r .cell-code}\nlibrary(dcurves)\n\ndca_prepost <- dca(\n sigdz ~ pre + post,\n data = acath_pred,\n label = list(\n pre = \"Age and Sex\",\n post = \"Age, Sex and Cholesterol\"))\n\ndca_prepost %>%\n plot(smooth = TRUE) + \n theme_classic() +\n theme(legend.position = \"none\")\n```\n:::\n\n\n![](./conventional_decision.svg)\n\n\n\n\n:::\n\n### rtichoke\n\n::: {layout-ncol=\"2\"}\n\n::: {.cell}\n\n```{.r .cell-code}\nlibrary(rtichoke)\nlibrary(plotly)\n\nperformance_data_dc <- \n prepare_performance_data(\n probs = list(\n \"Age and Sex\" = \n acath_pred$pre,\n \"Age, Sex and Cholesterol\" = \n acath_pred$post\n ),\n reals = list(acath_pred$sigdz)\n)\n\nperformance_data_dc %>%\n plot_decision_curve(\n col_values = \n c(\"#00BFC4\", \"#C77CFF\"),\n size = 350\n ) %>%\n layout(\n yaxis = list(\n range =\n c(-0.07, 0.7)\n )\n )\n```\n:::\n\n::: {.cell}\n::: {.cell-output-display}\n```{=html}\n
\n\n```\n:::\n:::\n\n:::\n:::\n\n## Specific Range of Probability Thresholds\n\n::: panel-tabset\n### dcurves\n\n::: {layout-ncol=\"2\"}\n\n::: {.cell}\n\n```{.r .cell-code}\nlibrary(dcurves)\n\ndca_prepost_15_35 <- dca(\n sigdz ~ pre + post,\n data = acath_pred,\n thresholds = seq(0.15, 0.35, by = 0.05),\n label = list(\n pre = \"Age and Sex\",\n post = \"Age, Sex and Cholesterol\")) %>%\n plot(type = 'net_benefit', \n smooth = FALSE, \n show_ggplot_code = FALSE)\n\ndca_prepost_15_35 + \n theme_classic() + \n theme(legend.position = \"none\")\n```\n:::\n\n\n\n\n![](conventional_decision_15_35.svg)\n:::\n\n### rtichoke\n\n::: {layout-ncol=\"2\"}\n\n::: {.cell}\n\n```{.r .cell-code}\nperformance_data_dc %>% \n rtichoke::plot_decision_curve(\n col_values = c(\"#00BFC4\", \"#C77CFF\"),\n min_p_threshold = 0.15, \n max_p_threshold = 0.35,\n size = 350\n ) %>% \n plotly::layout(\n yaxis = list(range =\n c(-0.07, 0.7))\n ) \n```\n:::\n\n::: {.cell}\n::: {.cell-output-display}\n```{=html}\n\n\n```\n:::\n:::\n\n:::\n:::\n\n## Interventions Avoided\n\n::: panel-tabset\n### dcurves\n\n::: {layout-ncol=\"2\"}\n\n::: {.cell}\n\n```{.r .cell-code}\n# code\n```\n:::\n\n\n![](./interventions_avoided.svg)\n:::\n\n### rtichoke\n\n::: {layout-ncol=\"2\"}\n\n::: {.cell}\n\n```{.r .cell-code}\nperformance_data_dc %>%\n rtichoke::plot_decision_curve(\n col_values = c(\"#F8766D\", \"#00BFC4\"),\n type = \"interventions avoided\",\n size = 350\n ) %>%\n plotly::layout(\n yaxis = list(range =\n c(-10, 100))\n )\n```\n:::\n\n::: {.cell}\n::: {.cell-output-display}\n```{=html}\n\n\n```\n:::\n:::\n\n:::\n:::\n\n## Conventional and Interventions Avoided Combined (rtichoke code)\n\n::: {layout-ncol=\"2\"}\n\n::: {.cell}\n\n```{.r .cell-code}\nperformance_data_dc %>%\n plot_decision_curve(\n col_values = \n c(\"#00BFC4\", \"#C77CFF\"),\n type = \"combined\",\n size = 500\n )\n```\n:::\n\n::: {.cell}\n::: {.cell-output-display}\n```{=html}\n\n\n```\n:::\n:::\n\n:::\n",
+ "markdown": "---\ntitle: \"DCA for Quantifying the Additional Benefit of a New Marker by Emily Vertosick and Andrew Vickers\"\ndate: \"2022-10-02\"\ncategories: \n - Replications\n - Decision\n - Emily Vertosick\n - Andrew Vickers\n - gt\n - gtsummary\n - dcurves\n - rms\n - Hmisc\nimage: \"image.jpg\"\ndraft: false\n---\n\n\n\n\n## Additional Benefit of a New Marker\n\nPrediction Model might gain accuracy if you'll add more relevant features to existing models, but many times it's not obvious what is the additional value of additional feature and how to quantify it in terms of Decision Making. The post [Decision curve analysis for quantifying the additional benefit of a new marker](https://www.fharrell.com/post/addmarkerdca) by Emily Vertosick and Andrew Vickers show a simple example (the code presented here is almost identical to the original code presented in the link).\n\n## Preparing the Data\n\n### Loading the Data with Hmisc\n\n\n::: {.cell}\n\n```{.r .cell-code}\nlibrary(Hmisc)\nlibrary(dplyr)\nlibrary(tibble)\n\ngetHdata(acath)\nacath <- subset(acath, !is.na(choleste))\n```\n:::\n\n\n### Fitting Logistic Regressions with rms\n\n\n::: {.cell}\n\n```{.r .cell-code}\nlibrary(rms)\n\npre <- lrm(sigdz ~ rcs(age,4) * sex, data = acath)\npre_pred <- predict(pre, type='fitted')\n\npost <- lrm(sigdz ~ rcs(age,4) * sex + \n rcs(choleste,4) + rcs(age,4) %ia% rcs(choleste,4), data = acath)\npost_pred <- predict(post, type='fitted')\n\nacath_pred <- bind_cols(\n acath,\n pre_pred %>% enframe(name = NULL, value = \"pre\"),\n post_pred %>% enframe(name = NULL, value = \"post\")\n )\n```\n:::\n\n\n## Conventional Decision Curve\n\n::: panel-tabset\n### dcurves\n\n::: {layout-ncol=\"2\"}\n\n::: {.cell}\n\n```{.r .cell-code}\nlibrary(dcurves)\n\ndca_prepost <- dca(\n sigdz ~ pre + post,\n data = acath_pred,\n label = list(\n pre = \"Age and Sex\",\n post = \"Age, Sex and Cholesterol\"))\n\ndca_prepost %>%\n plot(smooth = TRUE) + \n theme_classic() +\n theme(legend.position = \"none\")\n```\n:::\n\n\n![](./conventional_decision.svg)\n\n\n\n\n:::\n\n### rtichoke\n\n::: {layout-ncol=\"2\"}\n\n::: {.cell}\n\n```{.r .cell-code}\nlibrary(rtichoke)\nlibrary(plotly)\n\nperformance_data_dc <- \n prepare_performance_data(\n probs = list(\n \"Age and Sex\" = \n acath_pred$pre,\n \"Age, Sex and Cholesterol\" = \n acath_pred$post\n ),\n reals = list(acath_pred$sigdz)\n)\n\nperformance_data_dc %>%\n plot_decision_curve(\n col_values = \n c(\"#00BFC4\", \"#C77CFF\"),\n size = 350\n ) %>%\n plotly::layout(\n yaxis = list(\n range =\n c(-0.07, 0.7)\n )\n )\n```\n:::\n\n::: {.cell}\n::: {.cell-output-display}\n```{=html}\n\n\n```\n:::\n:::\n\n:::\n:::\n\n## Specific Range of Probability Thresholds\n\n::: panel-tabset\n### dcurves\n\n::: {layout-ncol=\"2\"}\n\n::: {.cell}\n\n```{.r .cell-code}\nlibrary(dcurves)\n\ndca_prepost_15_35 <- dca(\n sigdz ~ pre + post,\n data = acath_pred,\n thresholds = seq(0.15, 0.35, by = 0.05),\n label = list(\n pre = \"Age and Sex\",\n post = \"Age, Sex and Cholesterol\")) %>%\n plot(type = 'net_benefit', \n smooth = FALSE, \n show_ggplot_code = FALSE)\n\ndca_prepost_15_35 + \n theme_classic() + \n theme(legend.position = \"none\")\n```\n:::\n\n\n\n\n![](conventional_decision_15_35.svg)\n:::\n\n### rtichoke\n\n::: {layout-ncol=\"2\"}\n\n::: {.cell}\n\n```{.r .cell-code}\nperformance_data_dc %>% \n plot_decision_curve(\n col_values = c(\"#00BFC4\", \"#C77CFF\"),\n min_p_threshold = 0.15, \n max_p_threshold = 0.35,\n size = 350\n ) %>% \n plotly::layout(\n yaxis = list(range =\n c(-0.07, 0.7))\n ) \n```\n:::\n\n::: {.cell}\n::: {.cell-output-display}\n```{=html}\n\n\n```\n:::\n:::\n\n:::\n:::\n\n## Interventions Avoided\n\n::: panel-tabset\n### dcurves\n\n::: {layout-ncol=\"2\"}\n\n::: {.cell}\n\n```{.r .cell-code}\ndca_prepost %>%\n net_intervention_avoided() %>% \n plot(type = 'net_intervention_avoided', \n smooth = FALSE) + \n theme_classic() +\n theme(legend.position = \"none\")\n```\n:::\n\n\n![](./interventions_avoided.svg)\n:::\n\n### rtichoke\n\n::: {layout-ncol=\"2\"}\n\n::: {.cell}\n\n```{.r .cell-code}\nperformance_data_dc %>%\n plot_decision_curve(\n col_values = c(\"#F8766D\", \"#00BFC4\"),\n type = \"interventions avoided\",\n size = 350\n ) %>%\n plotly::layout(\n yaxis = list(range =\n c(-10, 100))\n )\n```\n:::\n\n::: {.cell}\n::: {.cell-output-display}\n```{=html}\n\n\n```\n:::\n:::\n\n:::\n:::\n\n## Conventional and Interventions Avoided Combined (rtichoke code)\n\n::: {layout-ncol=\"2\"}\n\n::: {.cell}\n\n```{.r .cell-code}\nperformance_data_dc %>%\n plot_decision_curve(\n col_values = \n c(\"#00BFC4\", \"#C77CFF\"),\n type = \"combined\",\n size = 500\n )\n```\n:::\n\n::: {.cell}\n::: {.cell-output-display}\n```{=html}\n\n\n```\n:::\n:::\n\n:::\n",
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-rtichoke blog - Box-Cox transformation from Feature Engineering by Max Kuhn and Kjell Johnson
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Box-Cox transformation from Feature Engineering by Max Kuhn and Kjell Johnson
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Max Kuhn
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Feature Engineering by Max Kuhn and Kjell Johnson
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June 6, 2012
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Welcome to rtichoke blog!
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This blog will be dedicated to the {rtichoke} package, which means that it will contain posts that are related to performance metrics and the possible related usability of {rtichoke}.
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Replications
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To make the package easier to use I plan to reproduce other people’s code with rtichoke, posts of this kind will be available under the category “replications”.
In this example you can see how Box-Cox transformation improves the discrimination capability of the logistic regression model without using any additional information.
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The code is almost identical to the original code that can be found on github.
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-rtichoke blog - Box-Cox transformation from Feature Engineering by Max Kuhn and Kjell Johnson
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Box-Cox transformation from Feature Engineering by Max Kuhn and Kjell Johnson
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ROC
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June 6, 2012
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If there are repeated groups on the same page, their tabs are synced:
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Welcome to rtichoke blog!
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This blog will be dedicated to the {rtichoke} package, which means that it will contain posts that are related to performance metrics and the possible related usability of {rtichoke}.
-
-
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Replications
-
To make the package easier to use I plan to reproduce other people’s code with rtichoke, posts of this kind will be available under the category “replications”.
In this example you can see how Box-Cox transformation improves the discrimination capability of the logistic regression model without using any additional information.
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Original Code
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The code is almost identical to the original code that can be found on github.
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diff --git a/_site/posts/2022-07-05-dca-for-quantifying-the-additional-benefit-of-a-new-marker-by-emily-vertosick-and-andrew-vickers/conventional_decision.svg b/_site/posts/2022-07-05-dca-for-quantifying-the-additional-benefit-of-a-new-marker-by-emily-vertosick-and-andrew-vickers/conventional_decision.svg
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-rtichoke blog - DCA for Quantifying the Additional Benefit of a New Marker by Emily Vertosick and Andrew Vickers
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DCA for Quantifying the Additional Benefit of a New Marker by Emily Vertosick and Andrew Vickers
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Decision
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Additional Benefit of a New Marker
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Prediction Model might gain accuracy if you’ll add more relevant features to existing models, but many times it’s not obvious what is the additional value of additional feature and how to quantify it in terms of Decision Making. The post Decision curve analysis for quantifying the additional benefit of a new marker by Emily Vertosick and Andrew Vickers show a simple example (the code presented here is almost identical to the original code presented in the link).
If there are repeated groups on the same page, their tabs are synced:
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Welcome to rtichoke blog!
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This blog will be dedicated to the {rtichoke} package, which means that it will contain posts that are related to performance metrics and the possible related usability of {rtichoke}.
-
-
-
Replications
-
To make the package easier to use I plan to reproduce other people’s code with rtichoke, posts of this kind will be available under the category “replications”.
In this example you can see how Box-Cox transformation improves the discrimination capability of the logistic regression model without using any additional information.
-
-
-
Original Code
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The code is almost identical to the original code that can be found on github.