diff --git a/tests.unit/parsers/test_dsc_parser.py b/tests.unit/parsers/test_dsc_parser.py
index 7c3490871..d8a5916a5 100644
--- a/tests.unit/parsers/test_dsc_parser.py
+++ b/tests.unit/parsers/test_dsc_parser.py
@@ -154,3 +154,28 @@ def test_dsc_include_relative_path(self):
             self.assertEqual(parser.LocalVars["INCLUDED"], "TRUE")  # make sure we got the defines
         finally:
             os.chdir(cwd)
+
+    def test_handle_integer_comparisons(self):
+        DSC_FILE = '''
+[Defines]
+DEFINE SERIAL_REGISTER_BASE = 0xFEDC9000
+[PcdsFixedAtBuild]
+!if $(SERIAL_REGISTER_BASE) == 0x3F8 OR $(SERIAL_REGISTER_BASE) == 0x3E8
+gEfiModulePkgTokenSpaceGuid.MyValue|0x04
+# UART0 is COM2/4 IRQ3
+!elseif $(SERIAL_REGISTER_BASE) == 0x2F8 OR $(SERIAL_REGISTER_BASE) == 0x2E8
+gEfiModulePkgTokenSpaceGuid.MyValue|0x03
+!endif
+!if $(SERIAL_REGISTER_BASE) >= 0x10000
+gEfiMdeModulePkgTokenSpaceGuid.PcdSerialUseMmio|TRUE
+gEfiMdeModulePkgTokenSpaceGuid.PcdSerialRegisterStride|4
+gEfiMdeModulePkgTokenSpaceGuid.PcdSerialClockRate|48000000
+!else
+'''
+        import pathlib
+        workspace = tempfile.mkdtemp()
+        dsc = pathlib.Path(workspace) / "dsc.dsc"
+        dsc.write_text(DSC_FILE)
+        parser = DscParser()
+        parser.SetEdk2Path(Edk2Path(workspace, []))
+        parser.ParseFile(dsc)