diff --git a/synapse/federation/sender/__init__.py b/synapse/federation/sender/__init__.py
index 3ad483efe079..a58cca4f826f 100644
--- a/synapse/federation/sender/__init__.py
+++ b/synapse/federation/sender/__init__.py
@@ -705,6 +705,11 @@ def send_presence_to_destinations(
         for destination in destinations:
             if destination == self.server_name:
                 continue
+
+            # T2B: Skip sending presence to servers we know don't support it
+            if destination == "matrix.org":
+                continue
+
             if not self._federation_shard_config.should_handle(
                 self._instance_name, destination
             ):