diff --git a/nxt_editor/__init__.py b/nxt_editor/__init__.py
index cf2523c..7aaae07 100644
--- a/nxt_editor/__init__.py
+++ b/nxt_editor/__init__.py
@@ -36,10 +36,7 @@ class StringSignaler(QtCore.QObject):
 
 
 def make_resources(qrc_path=None, result_path=None):
-    import PySide2
-    pyside_dir = os.path.dirname(PySide2.__file__)
-    full_pyside2rcc_path = os.path.join(pyside_dir, 'pyside2-rcc')
-    full_rcc_path = os.path.join(pyside_dir, 'rcc')
+    import subprocess
     this_dir = os.path.dirname(os.path.realpath(__file__))
     if not qrc_path:
         qrc_path = os.path.join(this_dir, 'resources/resources.qrc')
@@ -47,37 +44,13 @@ def make_resources(qrc_path=None, result_path=None):
         result_path = os.path.join(this_dir, 'qresources.py')
     msg = 'First launch nxt resource generation from {} to {}'
     logger.info(msg.format(qrc_path, result_path))
-    import subprocess
-    ver = ['-py2']
-    if sys.version_info[0] == 3:
-        ver += ['-py3']
-    args = [qrc_path] + ver + ['-o', result_path]
-    try:
-        subprocess.check_call(['pyside2-rcc'] + args)
-    except:
-        pass
-    else:
-        return
 
+    args = [qrc_path, '-o', result_path, '-g', 'python']
     try:
-        subprocess.check_call([full_pyside2rcc_path] + args)
+        subprocess.call(['pyside6-rcc'] + args)
     except:
-        pass
-    else:
-        return
-    try:
-        subprocess.check_call([full_rcc_path, '-g', 'python', qrc_path,
-                               '-o', result_path], cwd=pyside_dir)
-    except:
-        pass
-    else:
-        return
-    try:
-        subprocess.check_call(['rcc', '-g', 'python', qrc_path,
-                               '-o', result_path], cwd=pyside_dir)
-    except:
-        raise Exception("Failed to generate UI resources using pyside2 rcc!"
-                        " Reinstalling pyside2 may fix the problem. If you "
+        raise Exception("Failed to generate UI resources using PySide rcc!"
+                        " Reinstalling PySide6 may fix the problem. If you "
                         "know how to use rcc please build from: \"{}\" and "
                         "output to \"{}\"".format(qrc_path, result_path))
     else:
@@ -129,9 +102,12 @@ def launch_editor(paths=None, start_rpc=True):
 
 def show_new_editor(paths=None, start_rpc=True):
     path = None
-    if paths is not None:
+    if paths and isinstance(paths, list):
         path = paths[0]
         paths.pop(0)
+    elif isinstance(paths, str):
+        path = paths
+        paths = []
     else:
         paths = []
     # Deferred import since main window relies on us
diff --git a/nxt_editor/constants.py b/nxt_editor/constants.py
index 51c6174..c1bc4ee 100644
--- a/nxt_editor/constants.py
+++ b/nxt_editor/constants.py
@@ -22,7 +22,7 @@ class EDITOR_VERSION(object):
 
 
 class FONTS(object):
-    DEFAULT_FAMILY = 'RobotoMono-Regular'
+    DEFAULT_FAMILY = 'Roboto Mono'
     DEFAULT_SIZE = 10
 
 
diff --git a/nxt_editor/dialogs.py b/nxt_editor/dialogs.py
index c6653bc..998edaa 100644
--- a/nxt_editor/dialogs.py
+++ b/nxt_editor/dialogs.py
@@ -297,7 +297,7 @@ def build_widgets(self):
         self.save_details_button.released.connect(self.on_save_details)
 
         self.detail_buttons_layout = QtWidgets.QHBoxLayout()
-        self.detail_buttons_layout.addStretch(streth=1)
+        self.detail_buttons_layout.addStretch(1)
         self.detail_buttons_layout.addWidget(self.save_details_button)
         self.detail_buttons_layout.addWidget(self.copy_details_button)
 
@@ -314,7 +314,7 @@ def build_widgets(self):
         self.top_right_layout = QtWidgets.QVBoxLayout()
         self.top_right_layout.addWidget(self.text_label)
         self.top_right_layout.addWidget(self.info_label)
-        self.top_right_layout.addStretch(streth=1)
+        self.top_right_layout.addStretch(1)
         self.top_right_layout.addLayout(self.buttons_layout)
         self.top_layout = QtWidgets.QHBoxLayout()
         self.top_layout.addWidget(self.icon)
diff --git a/nxt_editor/dockwidgets/build_view.py b/nxt_editor/dockwidgets/build_view.py
index 3d21643..768e214 100644
--- a/nxt_editor/dockwidgets/build_view.py
+++ b/nxt_editor/dockwidgets/build_view.py
@@ -315,7 +315,7 @@ class BuildTable(QtWidgets.QTableView):
     """
     def __init__(self):
         super(BuildTable, self).__init__()
-        self.setSelectionMode(self.NoSelection)
+        self.setSelectionMode(QtWidgets.QAbstractItemView.NoSelection)
         self.horizontalHeader().hide()
         self.verticalHeader().hide()
         self.break_delegate = LetterCheckboxDelegeate('B')
@@ -342,7 +342,7 @@ def setModel(self, model):
         header = self.horizontalHeader()
         header.setStretchLastSection(False)
         header.setDefaultSectionSize(28)
-        header.setSectionResizeMode(header.Fixed)
+        header.setSectionResizeMode(QtWidgets.QHeaderView.Fixed)
         if header.count():
             column = BuildModel.PATH_COLUMN
             header.setSectionResizeMode(column, QtWidgets.QHeaderView.Stretch)
diff --git a/nxt_editor/dockwidgets/code_editor.py b/nxt_editor/dockwidgets/code_editor.py
index 0005dda..307a18c 100644
--- a/nxt_editor/dockwidgets/code_editor.py
+++ b/nxt_editor/dockwidgets/code_editor.py
@@ -1271,7 +1271,7 @@ def paintEvent(self, event):
 
     def get_width(self):
         count = self.editor.blockCount()
-        width = self.fontMetrics().width(str(count)) + 10
+        width = self.fontMetrics().horizontalAdvance(str(count)) + 10
         return width
 
     def update_width(self):
diff --git a/nxt_editor/dockwidgets/find_rep.py b/nxt_editor/dockwidgets/find_rep.py
index bd94f67..23aaa9c 100644
--- a/nxt_editor/dockwidgets/find_rep.py
+++ b/nxt_editor/dockwidgets/find_rep.py
@@ -196,7 +196,7 @@ def setModel(self, model):
         super(SearchResultsTree, self).setModel(model)
         header = self.header()
         header.setStretchLastSection(False)
-        header.setSectionResizeMode(header.ResizeToContents)
+        header.setSectionResizeMode(QtWidgets.QHeaderView.ResizeToContents)
         if self.model():
             self.model().modelReset.connect(self.expandAll)
 
diff --git a/nxt_editor/dockwidgets/layer_manager.py b/nxt_editor/dockwidgets/layer_manager.py
index 4aed6f5..3c2aeea 100644
--- a/nxt_editor/dockwidgets/layer_manager.py
+++ b/nxt_editor/dockwidgets/layer_manager.py
@@ -100,7 +100,7 @@ def setModel(self, model):
         header = self.header()
         header.setStretchLastSection(False)
         header.setDefaultSectionSize(LayerTreeView.SIZE)
-        header.setSectionResizeMode(header.Fixed)
+        header.setSectionResizeMode(QtWidgets.QHeaderView.Fixed)
         if header.count():
             header.setSectionResizeMode(0, QtWidgets.QHeaderView.Stretch)
             self.hideColumn(LayerModel.TARGET_COLUMN)
diff --git a/nxt_editor/dockwidgets/output_log.py b/nxt_editor/dockwidgets/output_log.py
index b5ec502..0ec8508 100644
--- a/nxt_editor/dockwidgets/output_log.py
+++ b/nxt_editor/dockwidgets/output_log.py
@@ -205,7 +205,7 @@ def __init__(self, graph_model=None, parent=None):
 
         self.buttons_layout = QtWidgets.QHBoxLayout()
         self.buttons_layout.addWidget(self.log_filter_button)
-        self.buttons_layout.addStretch(stretch=1)
+        self.buttons_layout.addStretch(1)
         self.buttons_layout.addWidget(self.clear_rich_button)
 
         self.rich_output_layout = QtWidgets.QVBoxLayout()
diff --git a/nxt_editor/dockwidgets/property_editor.py b/nxt_editor/dockwidgets/property_editor.py
index 2f80f38..2c114e0 100644
--- a/nxt_editor/dockwidgets/property_editor.py
+++ b/nxt_editor/dockwidgets/property_editor.py
@@ -12,7 +12,7 @@
     QtCore.QStringListModel
 except AttributeError:
     del QtCore
-    from PySide2 import QtCore
+    from PySide6 import QtCore
 
 # Internal
 from nxt_editor import user_dir
diff --git a/nxt_editor/dockwidgets/syntax.py b/nxt_editor/dockwidgets/syntax.py
index 246c23f..6b3eb07 100644
--- a/nxt_editor/dockwidgets/syntax.py
+++ b/nxt_editor/dockwidgets/syntax.py
@@ -39,15 +39,15 @@ class PythonHighlighter(QSyntaxHighlighter):
         # Comparison
         '==', '!=', '<', '<=', '>', '>=',
         # Arithmetic
-        '\+', '-', '\*', '/', '//', '\%', '\*\*',
+        r'\+', '-', r'\*', '/', '//', r'\%', r'\*\*',
         # In-place
-        '\+=', '-=', '\*=', '/=', '\%=',
+        r'\+=', '-=', r'\*=', '/=', r'\%=',
         # Bitwise
-        '\^', '\|', '\&', '\~', '>>', '<<'
+        r'\^', r'\|', r'\&', r'\~', '>>', '<<'
     ]
 
     # Python braces
-    braces = ['\{', '\}', '\(', '\)', '\[', '\]']
+    braces = [r'\{', r'\}', r'\(', r'\)', r'\[', r'\]']
 
     def __init__(self, document=None):
         super(PythonHighlighter, self).__init__(document)
@@ -117,7 +117,8 @@ def highlightBlock(self, text):
         # Do other syntax formatting
         for rule in self.rules:
             expression, nth, formatting = rule
-            index = expression.indexIn(text, 0)
+            match = expression.match(text)
+            index = match.capturedStart()
             # This is here because you can't do nested logic in regex
             nested = 0
             if rule in self.special_rules:
@@ -126,10 +127,10 @@ def highlightBlock(self, text):
 
             while index >= 0:
                 # We actually want the index of the nth match
-                index = expression.pos(nth)
-                length = len(expression.cap(nth))
+                index = match.capturedStart(nth)
+                length = len(match.captured(nth))
                 self.setFormat(index, length + nested, formatting)
-                index = expression.indexIn(text, index + length)
+                index = match.capturedStart(text)
 
         self.setCurrentBlockState(0)
 
@@ -151,17 +152,19 @@ def match_multiline(self, text, delimiter, in_state, style):
             add = 0
         # Otherwise, look for the delimiter on this line
         else:
-            start = delimiter.indexIn(text)
+            match = delimiter.match(text)
+            start = match.capturedStart()
             # Move past this match
-            add = delimiter.matchedLength()
+            add = match.capturedLength()
 
         # As long as there's a delimiter match on this line...
         while start >= 0:
+            match = delimiter.match(text)
             # Look for the ending delimiter
-            end = delimiter.indexIn(text, start + add)
+            end = match.capturedStart() + (start + add)
             # Ending delimiter on this line?
             if end >= add:
-                length = end - start + add + delimiter.matchedLength()
+                length = end - start + add + match.capturedLength()
                 self.setCurrentBlockState(0)
             # No; multi-line string
             else:
@@ -170,7 +173,7 @@ def match_multiline(self, text, delimiter, in_state, style):
             # Apply formatting
             self.setFormat(start, length, style)
             # Look for the next match
-            start = delimiter.indexIn(text, start + length)
+            start = match.capturedStart() + (start + length)
 
         # Return True if still inside a multi-line string, False otherwise
         if self.currentBlockState() == in_state:
diff --git a/nxt_editor/dockwidgets/widget_builder.py b/nxt_editor/dockwidgets/widget_builder.py
index b773b2c..1ecb1a2 100644
--- a/nxt_editor/dockwidgets/widget_builder.py
+++ b/nxt_editor/dockwidgets/widget_builder.py
@@ -15,7 +15,7 @@
     QtCore.QStringListModel
 except AttributeError:
     del QtCore
-    from PySide2 import QtCore
+    from PySide6 import QtCore
 
 # Internal
 import nxt_editor
diff --git a/nxt_editor/node_graphics_item.py b/nxt_editor/node_graphics_item.py
index b8de726..128f4b7 100644
--- a/nxt_editor/node_graphics_item.py
+++ b/nxt_editor/node_graphics_item.py
@@ -9,8 +9,6 @@
 from Qt import QtWidgets
 from Qt import QtGui
 from Qt import QtCore
-from PySide2 import __version_info__ as qt_version
-
 # Internal
 import nxt_editor
 from nxt import nxt_path, nxt_node
@@ -25,16 +23,8 @@
 
 MIN_LOD = user_prefs.get(USER_PREF.LOD, .4)
 
-_pyside_version = qt_version
-
-
-if _pyside_version[1] < 11:
-    graphic_type = QtWidgets.QGraphicsItem
-else:
-    graphic_type = QtWidgets.QGraphicsObject
-
 
-class NodeGraphicsItem(graphic_type):
+class NodeGraphicsItem(QtWidgets.QGraphicsObject):
     """The graphics item used to represent nodes in the graph. Contains
     instances of NodeGraphicsPlug for each attribute on the associated node.
     Contains functionality for arranging children into stacks.
@@ -262,13 +252,13 @@ def screen_pos(self):
     def itemChange(self, change, value):
         """Override of QtWidgets.QGraphicsItem itemChange."""
         # keep connections drawing to node as it moves
-        if change is self.ItemScenePositionHasChanged:
+        if change is QtWidgets.QGraphicsItem.ItemPositionChange:
             graphics = self.view.get_node_connection_graphics(self.node_path)
             for connection in graphics:
                 connection.rebuild_line()
         # TODO: Take into account the positions of every selected node and snap them all to a grid as soon as
         #  the user preses shift. This will avoid the weird wavy snapping effect we have right now
-        if change == self.ItemPositionChange and self.scene():
+        if change == QtWidgets.QGraphicsItem.ItemPositionChange and self.scene():
             ml = QtWidgets.QApplication.mouseButtons() == QtCore.Qt.LeftButton
             shift = QtWidgets.QApplication.keyboardModifiers() == QtCore.Qt.ShiftModifier
             force_snap = self.view.alignment_actions.snap_action.isChecked()
diff --git a/nxt_editor/pixmap_button.py b/nxt_editor/pixmap_button.py
index 3239ad4..e4a07f6 100644
--- a/nxt_editor/pixmap_button.py
+++ b/nxt_editor/pixmap_button.py
@@ -71,7 +71,7 @@ def paintEvent(self, event):
                 pix = self.pixmap_pressed
 
         painter = QtGui.QPainter(self)
-        painter.drawPixmap(event.rect(), pix)
+        painter.drawPixmap(event.rect(), QtGui.QPixmap(pix))
         del painter
 
     def enterEvent(self, event):
diff --git a/nxt_editor/stage_view.py b/nxt_editor/stage_view.py
index 11151ec..d6ad664 100644
--- a/nxt_editor/stage_view.py
+++ b/nxt_editor/stage_view.py
@@ -8,12 +8,12 @@
 from Qt import QtWidgets
 from Qt import QtGui
 from Qt import QtCore
+from Qt import QtCompat
 
 # Interal
 import nxt_editor
 from nxt import nxt_node, tokens
-from nxt_editor.node_graphics_item import (NodeGraphicsItem, NodeGraphicsPlug,
-                                           _pyside_version)
+from nxt_editor.node_graphics_item import NodeGraphicsItem, NodeGraphicsPlug
 from nxt_editor.connection_graphics_item import AttrConnectionGraphic
 from nxt_editor.dialogs import NxtWarningDialog
 from nxt_editor.commands import *
@@ -42,8 +42,6 @@ def __init__(self, model, parent=None):
         super(StageView, self).__init__(parent=parent)
         self.main_window = parent
         self._do_anim_pref = user_prefs.get(USER_PREF.ANIMATION, True)
-        if _pyside_version[1] < 11:
-            self._do_anim_pref = False
         self.do_animations = self._do_anim_pref
         self.once_sec_timer = QtCore.QTimer(self)
         self.once_sec_timer.timeout.connect(self.calculate_fps)
@@ -79,8 +77,8 @@ def __init__(self, model, parent=None):
         self.setVerticalScrollBarPolicy(QtCore.Qt.ScrollBarAlwaysOff)
         self.horizontalScrollBar().setValue(0)
         self.verticalScrollBar().setValue(0)
-        self.setOptimizationFlag(self.DontSavePainterState, enabled=True)
-        self.setOptimizationFlag(self.DontAdjustForAntialiasing, enabled=True)
+        self.setOptimizationFlag(QtWidgets.QGraphicsView.DontSavePainterState, enabled=True)
+        self.setOptimizationFlag(QtWidgets.QGraphicsView.DontAdjustForAntialiasing, enabled=True)
         # scene
         self._scene = QtWidgets.QGraphicsScene()
         self.setScene(self._scene)
@@ -700,7 +698,7 @@ def mousePressEvent(self, event):
             self.zoom_start_pos = event.pos()
             self._previous_mouse_pos = event.pos()
             event.accept()
-        if event.buttons() == QtCore.Qt.LeftButton | QtCore.Qt.MidButton:
+        if event.buttons() == QtCore.Qt.LeftButton | QtCore.Qt.MiddleButton:
             self.zooming = True
             self.zoom_start_pos = event.pos()
             self._previous_mouse_pos = event.pos()
@@ -825,11 +823,11 @@ def mouseReleaseEvent(self, event):
             event.accept()
 
         if self.zooming:
-            if event.buttons() == QtCore.Qt.LeftButton | QtCore.Qt.MidButton:
+            if event.buttons() == QtCore.Qt.LeftButton | QtCore.Qt.MiddleButton:
                 self.zooming = False
             elif event.buttons() == QtCore.Qt.LeftButton:
                 self.zooming = False
-            elif event.buttons() == QtCore.Qt.MidButton:
+            elif event.buttons() == QtCore.Qt.MiddleButton:
                 self.zooming = False
         if (self._rubber_band_origin is not None and
            event.button() is QtCore.Qt.LeftButton):
@@ -993,11 +991,11 @@ def mouseDoubleClickEvent(self, event):
                     item.collapse_node()
 
     def wheelEvent(self, event):
-        self._view_pos = event.pos()
+        self._view_pos = event.position().toPoint()
         self._scene_pos = self.mapToScene(self._view_pos)
 
         try:
-            new_scale = event.delta() * .001 + 1.0
+            new_scale = event.angleDelta().y() * .001 + 1.0
         except AttributeError:
             new_scale = 1.1
 
diff --git a/nxt_editor/user_dir.py b/nxt_editor/user_dir.py
index 6353f68..2b6c4c9 100644
--- a/nxt_editor/user_dir.py
+++ b/nxt_editor/user_dir.py
@@ -10,6 +10,7 @@
 
 import json
 import logging
+import shutil
 import sys
 
 if sys.version_info[0] == 2:
@@ -209,10 +210,10 @@ def read(self):
             return
         try:
             with open(self.path, 'r+b') as fp:
-                if sys.version_info[0] == 2:
-                    contents = pickle.load(fp)
-                else:
-                    contents = pickle.load(fp, encoding='bytes')
+                contents = pickle.load(fp, encoding='bytes')
+        except ModuleNotFoundError as e:
+            if 'PySide2' in e.msg:
+                shutil.move(self.path, self.path + '.backup')
         except pickle.UnpicklingError:
             broken_files.setdefault(self.path, 0)
             times_hit = broken_files[self.path]
diff --git a/setup.py b/setup.py
index 2f524c9..551b78d 100644
--- a/setup.py
+++ b/setup.py
@@ -32,7 +32,7 @@
     url="https://github.com/nxt-dev/nxt_editor",
     packages=setuptools.find_packages(),
     python_requires=">=3.7, <3.12",
-    install_requires=["nxt-core<1.0,>=0.14", "qt.py<3", "pyside2>=5.11,<=5.16"],
+    install_requires=["nxt-core<1.0,>=0.14", "qt.py<3", "PySide6>=6,<6.8"],
     package_data={
         # covers text nxt files
         "": ["*.nxt"],