diff --git a/connexion/decorators/response.py b/connexion/decorators/response.py
index 0aa58870d..6b02477aa 100644
--- a/connexion/decorators/response.py
+++ b/connexion/decorators/response.py
@@ -27,7 +27,7 @@ def __call__(self, function: t.Callable) -> t.Callable:
 
     def build_framework_response(self, handler_response):
         data, status_code, headers = self._unpack_handler_response(handler_response)
-        content_type = self._infer_content_type(data, headers)
+        content_type = self._infer_content_type(data, status_code, headers)
         if not self.framework.is_framework_response(data):
             data = self._serialize_data(data, content_type=content_type)
             status_code = status_code or self._infer_status_code(data)
@@ -37,7 +37,7 @@ def build_framework_response(self, handler_response):
         )
 
     @staticmethod
-    def _infer_content_type(data: t.Any, headers: dict) -> t.Optional[str]:
+    def _infer_content_type(data: t.Any, status_code: int, headers: dict) -> t.Optional[str]:
         """Infer the response content type from the returned data, headers and operation spec.
 
         :param data: Response data
@@ -50,7 +50,7 @@ def _infer_content_type(data: t.Any, headers: dict) -> t.Optional[str]:
         content_type = utils.extract_content_type(headers)
 
         # TODO: don't default
-        produces = list(set(operation.produces))
+        produces = list(set(operation.responses.get(str(status_code), {}).get("content", {}).keys()))
         if data is not None and not produces:
             produces = ["application/json"]