diff --git a/Cargo.lock b/Cargo.lock
index 39de5e4..1fcbc1d 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -1379,9 +1379,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3"
-version = "0.22.5"
+version = "0.23.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "3d922163ba1f79c04bc49073ba7b32fd5a8d3b76a87c955921234b8e77333c51"
+checksum = "7ebb0c0cc0de9678e53be9ccf8a2ab53045e6e3a8be03393ceccc5e7396ccb40"
 dependencies = [
  "anyhow",
  "cfg-if",
@@ -1398,9 +1398,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-build-config"
-version = "0.22.5"
+version = "0.23.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "bc38c5feeb496c8321091edf3d63e9a6829eab4b863b4a6a65f26f3e9cc6b179"
+checksum = "80e3ce69c4ec34476534b490e412b871ba03a82e35604c3dfb95fcb6bfb60c09"
 dependencies = [
  "once_cell",
  "target-lexicon",
@@ -1408,9 +1408,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-ffi"
-version = "0.22.5"
+version = "0.23.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "94845622d88ae274d2729fcefc850e63d7a3ddff5e3ce11bd88486db9f1d357d"
+checksum = "3b09f311c76b36dfd6dd6f7fa6f9f18e7e46a1c937110d283e80b12ba2468a75"
 dependencies = [
  "libc",
  "pyo3-build-config",
@@ -1418,9 +1418,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-macros"
-version = "0.22.5"
+version = "0.23.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "e655aad15e09b94ffdb3ce3d217acf652e26bbc37697ef012f5e5e348c716e5e"
+checksum = "fd4f74086536d1e1deaff99ec0387481fb3325c82e4e48be0e75ab3d3fcb487a"
 dependencies = [
  "proc-macro2",
  "pyo3-macros-backend",
@@ -1430,9 +1430,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-macros-backend"
-version = "0.22.5"
+version = "0.23.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "ae1e3f09eecd94618f60a455a23def79f79eba4dc561a97324bf9ac8c6df30ce"
+checksum = "9e77dfeb76b32bbf069144a5ea0a36176ab59c8db9ce28732d0f06f096bbfbc8"
 dependencies = [
  "heck 0.5.0",
  "proc-macro2",
diff --git a/Cargo.toml b/Cargo.toml
index 81ddfe8..b646d76 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -9,7 +9,7 @@ name = "sourmash_plugin_directsketch"
 crate-type = ["cdylib"]
 
 [dependencies]
-pyo3 = { version = "0.22.5", features = ["extension-module", "anyhow"] }
+pyo3 = { version = "0.23.1", features = ["extension-module", "anyhow"] }
 rayon = "1.10.0"
 serde = { version = "1.0.204", features = ["derive"] }
 sourmash = { version = "0.16.0"}