diff --git a/cmake/nuttx_sethost.cmake b/cmake/nuttx_sethost.cmake
index 18b3a49701632..a7505605cc498 100644
--- a/cmake/nuttx_sethost.cmake
+++ b/cmake/nuttx_sethost.cmake
@@ -79,12 +79,15 @@ function(nuttx_sethost)
   if("${NUTTX_BOARD}" STREQUAL "sim")
     if(ARCHITECTURE STREQUAL "x86_64")
       message(" Select HOST_X86_64=y")
-      if(CMAKE_HOST_SYSTEM_NAME MATCHES "MSYS|CYGWIN|Windows")
+      list(APPEND NUTTX_SYSTEM_SETHOST "HOST_X86_64=y")
+      if(CMAKE_HOST_SYSTEM_NAME MATCHES "Linux|Darwin|FreeBSD")
+        # Enable the System V ABI
+        list(APPEND NUTTX_SYSTEM_SETHOST "SIM_X8664_SYSTEMV=y")
+      elseif(CMAKE_HOST_SYSTEM_NAME MATCHES "MSYS|CYGWIN|Windows")
         # Enable Microsoft ABI and the System V ABI
         list(APPEND NUTTX_SYSTEM_SETHOST "SIM_X8664_SYSTEMV=y")
         list(APPEND NUTTX_SYSTEM_SETHOST "SIM_X8664_MICROSOFT=y") 
       endif()
-      list(APPEND NUTTX_SYSTEM_SETHOST "HOST_X86_64=y")
     elseif(ARCHITECTURE STREQUAL "x86")
       message(" Select HOST_X86=y")
       list(APPEND NUTTX_SYSTEM_SETHOST "HOST_X86=y")