From 14370e44fa9f923557f52f978e17da94558f3d62 Mon Sep 17 00:00:00 2001
From: Sigve Nakken <sigven@ifi.uio.no>
Date: Wed, 19 Jun 2024 00:18:59 +0200
Subject: [PATCH] drug classifications and CIViC update

---
 NEWS.md                   |   5 +++++
 R/sysdata.rda             | Bin 733 -> 748 bytes
 data-raw/drug_utilities.R |   4 +++-
 3 files changed, 8 insertions(+), 1 deletion(-)

diff --git a/NEWS.md b/NEWS.md
index ef1a55e..44d9b1a 100644
--- a/NEWS.md
+++ b/NEWS.md
@@ -1,3 +1,8 @@
+# Version 1.6.10 
+
+* Fixed some erroneous drug classifications
+* CIViC update (20240618)
+
 # Version 1.6.8 (June 7th 2024)
 
 * NCI update (24.05d)
diff --git a/R/sysdata.rda b/R/sysdata.rda
index 822ade6b729c5eb1b16ae084b248acc3868add44..c0759ef027dac826924e2c45d1c19b9c5a7ceee4 100644
GIT binary patch
literal 748
zcmV<I0u%j0T4*^jL0KkKS(EMc^Z)_O|G@uy$vEHxf8amg|M0*6|L{Nn01?0fTpiat
znUK_{qf-DzMD;N}MxM$OMxLSQhmvhT&@^ZP<vgJgQRK#`{S6v2r>V4hnkJeyqX-Qc
zCYVD*38rc>Qz-R6P-y@gNCBV#000000iYy`G*dM*5T~j638==P8fKcBW~P}2jWqP0
zpc)>Uju!0fywb2w5>6z2*fqXJHP5voLHX&2Z34K|wVtQs-G8>XND(ojqJ&d@p-c;?
zjCp?(^}fesutr)wnPI=5N4`ATucHeg7=#Iggvela2Vnpj7+g$%tYm^wS`>A-DgkNL
zh*1KG@JcN8!;DzsmK9k2*J3#(zAZxa0_wYKmzHlG9gvdXr;7CNd5j&oggPt=9srPW
zG>3wVat+9bDeG6=fCMzwQ8qsiNG`L(5fTj)mBOZHEHXEl5b&A@7&$&T*`VQoN&pf=
z{INpcFU!0DHJ)K4cmS!Yc9g;Jfs(F~ngT^kY%K|sm9UjEKFlNv25@meQTY@wY#FoG
z*0H}HW*?;Fuzy8!ZL4C6oS|z|xBQJAQ8$BmZbUB)bTI3gX`%idELTzo?T@?sSstof
zg52m<RJ%}HC&3-3Vw%VjTqsHqK<4uw1Iv?Q^le67E&d!Z@_0>No0d7poLB^Zu+T(r
z6&R`z1~YyqrvNVs>O|HGfL+wETAL1M=QP6NW~1)sR+V%HA_8xmk;G}|X&H?mKdbX-
z$F6Ogw@oMr;^`a5kvx=cNkyq+E-t4thkBzhX$NBqxXs;4apStW=hw}jNFdoCGcz4c
zXSn9517cBnQHHR58u)h<DNVWTvVqfjwE}V+A_OmqkU-F>QV^l;vac$JPHSd*ofiC7
zk~yi`$KRh9O|FYObc*Ce%y+rwCTIxK^|Z0wWILN~KcVw(OHQBUQcyPQ6}s!$5j=wA
eZj5`7<N4}~D;xi`&O($I{9VZu;X*=Bx7W}|uvsJk

literal 733
zcmV<30wVoFT4*^jL0KkKS<nlPFaQC*f588H%5h)=f8am=_wc{}|FA#+01?0fTo}na
zm};1m(`g$N$nt6E)iFG#$~>S3n@>?042FT~c}&s`N`9k82+Dd8O${(lPzHlQ001-%
z8Ud+KQzxj?AO?Y^fB<Qr13)wY005FGn5Uq~LlKZ@YBXtpN1`who}y{#GGyCP!o;<n
ztZX7^5^xU|3SR>h&9M?e<@%|XaawCFFKh2>zDivnMN_(DPjt_EmSHWT5##>N-tu}!
zQ5&=T+8w5&pTlnMaxXFwpdd^nCPM?TI|u-wg`CI>gCrF1i-c2xU|tz;3nluZ(2B^S
z#~i$uq&9_=SmhM&TI05p$v=z*aa`OJ#cE+%uP(P995=3ruux4s<Atp(`jt0W4Ah1N
zB?P%2>_|{A!aP5?A#8P+4a@<nNj+q~y6O{9#+{SI-kDN>?uBEn9~&SYR?270_0JP%
z0LLbz=qTEmUdpKTK90pY7<T+AmDur7lB=yG_tSg7E&S|RUnd}oc4Pcb!mY72b>HE7
z{2Tqy&wXM$ROp*5+za8L%h5*NCu^S3Wp>p!4FgRkmypO2;V9{pC<-gsD7X_6-KvuU
zWI6gFNic99icUcbL8jRT8T>C04AGc5Y>NT{nu-MTe?;-8sRT-|3aQBpthgovLQc5v
zJ6(40g#<3BDxCIYxj9O#8_c7*udu2L==}ZuAtu*8ty<#>IHW{FFrrI0hF6xm92b~g
zHgpV?hge=ngeHmh<f)y&t&4T4L5$m++<IKk?vS8#ed$N0!(<mmF=Qf8*#)qC!055&
ztI1YOG{8oAa5xas&|pBw`q+dhknFT^7)r{JPg|l}b+y<<8#XIb+dc^mD<X~qQI3en
z+7S(PszEa&ZjD|Dq8M(^v=HWD{k$^`g@!Rv!IHR(QVWT@Ce*)@#x59hTG3TA(?W$P
PFZjEXDZ+$?fLw8a51~+$

diff --git a/data-raw/drug_utilities.R b/data-raw/drug_utilities.R
index 6a3cc0d..384c742 100644
--- a/data-raw/drug_utilities.R
+++ b/data-raw/drug_utilities.R
@@ -2288,6 +2288,9 @@ assign_drug_category <- function(drug_df = NULL,
     dplyr::mutate(atc_drug_entry = dplyr::case_when(
       !is.na(atc_drug_entry) &
       (tolower(atc_drug_entry) == "sotorasib" |
+         tolower(atc_drug_entry) == "ivosidenib" |
+         tolower(atc_drug_entry) == "enasidenib" |
+         tolower(atc_drug_entry) == "venetoclax" |
         tolower(atc_drug_entry) == "adagrasib") ~ as.character(NA),
       TRUE ~ as.character(atc_drug_entry)
     )) |>
@@ -2742,7 +2745,6 @@ assign_drug_category <- function(drug_df = NULL,
       as.logical(cancer_target_classified)
     ))
     
-  
   drug_df <- remove_duplicate_chembl_ids(
     drug_df = classified_drugs_all_final)