diff --git a/docs/installation.md b/docs/installation.md
index 032421b4..5418295a 100644
--- a/docs/installation.md
+++ b/docs/installation.md
@@ -34,12 +34,16 @@ The DGE interface of pertpy requires additional dependencies that can be install
 pip install pertpy[de]
 ```
 
-Note that edger in pertpy requires edger to be installed:
+Note that edger in pertpy requires edger and rpy2 to be installed:
 
 ```R
 BiocManager::install("edgeR")
 ```
 
+```console
+pip install rpy2
+```
+
 ## From sources
 
 The sources for pertpy can be downloaded from the [Github repo].
diff --git a/pyproject.toml b/pyproject.toml
index 1ca348a6..7139813d 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -75,7 +75,6 @@ coda = [
 de = [
     "formulaic",
     "pydeseq2",
-    "rpy2"
 ]
 dev = [
     "pre-commit",