diff --git a/.github/workflows/build.yml b/.github/workflows/build.yml
index 7b8ba0b31..1ccf97f4f 100644
--- a/.github/workflows/build.yml
+++ b/.github/workflows/build.yml
@@ -3,18 +3,19 @@ name: CI
 on: [push, pull_request]
 
 jobs:
-  build:
+  build-Linux:
 
     runs-on: ubuntu-22.04
 
     steps:
-    - uses: actions/checkout@v3
+    - uses: actions/checkout@v4.0.0
 
     - name: Install system dependencies
       run: >
         sudo apt-get update;
         sudo apt-get --no-install-recommends install
         catch2
+        cmake
         libfreetype6-dev
         libglew-dev
         libglm-dev
@@ -25,7 +26,7 @@ jobs:
         python-is-python3
         python3-biopython
         python3-dev
-        python3-distutils
+        python3-setuptools
         python3-numpy
         python3-pil
         python3-pytest
@@ -49,3 +50,85 @@ jobs:
     - name: Test
       run: |
         ./install-prefix/bin/pymol -ckqy testing/testing.py --run all
+
+  build-Windows:
+
+    runs-on: windows-latest
+
+    env:
+      CONDA_ROOT: ${{github.workspace}}\..\tmp\mambaforge
+      MAMBAFORGE_EXEC: ${{github.workspace}}\..\tmp\mambaforge.exe
+
+    steps:
+    - uses: actions/checkout@v4.0.0
+    - name: Download miniconda
+      shell: cmd
+      run: |-
+        if not exist %CONDA_ROOT% mkdir %CONDA_ROOT%
+        curl -L -o %MAMBAFORGE_EXEC% https://github.com/conda-forge/miniforge/releases/download/24.3.0-0/Mambaforge-24.3.0-0-Windows-x86_64.exe
+        start /wait %MAMBAFORGE_EXEC% /S /D=%CONDA_ROOT%
+
+    - name: Set up Miniconda
+      shell: cmd
+      run: |-
+        CALL %CONDA_ROOT%\\Scripts\\activate.bat
+        conda install -y -c conda-forge -c schrodinger python cmake libpng freetype pyqt glew libxml2 numpy catch2=2.13.3 glm libnetcdf collada2gltf pytest
+
+    - name: Conda info
+      shell: cmd
+      run: |-
+        CALL %CONDA_ROOT%\\Scripts\\activate.bat
+        conda info
+
+    - name: Get additional sources
+      shell: cmd
+      run: |
+        git clone --depth 1 https://github.com/rcsb/mmtf-cpp.git
+        cp -R mmtf-cpp/include/mmtf* include/
+
+    - name: Build PyMOL
+      shell: cmd
+      run: |
+        CALL %CONDA_ROOT%\\Scripts\\activate.bat
+        python setup.py --testing install --prefix=install-prefix
+
+    - name: Test
+      shell: cmd
+      run: |
+        CALL %CONDA_ROOT%\\Scripts\\activate.bat
+        install-prefix\\Scripts\\pymol.bat -ckqy testing\\testing.py --run all
+
+  build-MacOS:
+
+    runs-on: macos-latest
+
+    env:
+      CONDA_ROOT: "/tmp/miniconda"
+      MAMBAFORGE_EXEC: ${{github.workspace}}\..\tmp\mambaforge.exe
+
+    steps:
+    - uses: actions/checkout@v4.0.0
+    - name: Set up Miniconda and Build
+      run: |-
+        curl -L -o $CONDA_ROOT.sh https://github.com/conda-forge/miniforge/releases/download/24.3.0-0/Mambaforge-MacOSX-x86_64.sh
+        bash $CONDA_ROOT.sh -b -p $CONDA_ROOT
+        export PATH="$CONDA_ROOT/bin:$PATH"
+        conda config --set quiet yes
+        conda install -y -c conda-forge -c schrodinger python cmake libpng freetype pyqt glew libxml2 numpy catch2=2.13.3 glm libnetcdf collada2gltf pytest
+        conda info
+
+    - name: Get additional sources
+      run: |
+        git clone --depth 1 https://github.com/rcsb/mmtf-cpp.git
+        cp -R mmtf-cpp/include/mmtf* include/
+
+    - name: Build PyMOL
+      run: |-
+        export MACOSX_DEPLOYMENT_TARGET=12.0
+        export PATH="$CONDA_ROOT/bin:$PATH"
+        python setup.py install --prefix=install-prefix
+
+    - name: Test
+      run: |-
+        export PATH="$CONDA_ROOT/bin:$PATH"
+        ./install-prefix/bin/pymol -ckqy testing/testing.py --run all