diff --git a/src/SQLite.cs b/src/SQLite.cs
index 76c1fe5f..0ce075e0 100644
--- a/src/SQLite.cs
+++ b/src/SQLite.cs
@@ -2091,7 +2091,7 @@ public enum NotifyTableChangedAction
 	/// </summary>
 	public class SQLiteConnectionString
 	{
-		public string ConnectionString { get; }
+		public string UniqueKey { get; }
 		public string DatabasePath { get; }
 		public bool StoreDateTimeAsTicks { get; }
 		public object Key { get; }
@@ -2200,7 +2200,7 @@ public SQLiteConnectionString (string databasePath, SQLiteOpenFlags openFlags, b
 			if (key != null && !((key is byte[]) || (key is string)))
 				throw new ArgumentException ("Encryption keys must be strings or byte arrays", nameof (key));
 
-			ConnectionString = databasePath;
+			UniqueKey = string.Format ("{0}_{1:X8}", databasePath, (uint)openFlags);
 			StoreDateTimeAsTicks = storeDateTimeAsTicks;
 			Key = key;
 			PreKeyAction = preKeyAction;
diff --git a/src/SQLiteAsync.cs b/src/SQLiteAsync.cs
index 15a63b97..77255098 100644
--- a/src/SQLiteAsync.cs
+++ b/src/SQLiteAsync.cs
@@ -1363,9 +1363,9 @@ public static SQLiteConnectionPool Shared {
 
 		public SQLiteConnectionWithLock GetConnection (SQLiteConnectionString connectionString)
 		{
+			var key = connectionString.UniqueKey;
 			Entry entry;
 			lock (_entriesLock) {
-				string key = connectionString.ConnectionString;
 				if (!_entries.TryGetValue (key, out entry)) {
 					entry = new Entry (connectionString);
 					_entries[key] = entry;
@@ -1376,15 +1376,13 @@ public SQLiteConnectionWithLock GetConnection (SQLiteConnectionString connection
 
 		public void CloseConnection (SQLiteConnectionString connectionString)
 		{
-			var key = connectionString.ConnectionString;
-
+			var key = connectionString.UniqueKey;
 			Entry entry;
 			lock (_entriesLock) {
 				if (_entries.TryGetValue (key, out entry)) {
 					_entries.Remove (key);
 				}
 			}
-
 			entry?.Close ();
 		}
 
@@ -1407,7 +1405,8 @@ public void Reset ()
 
 	/// <summary>
 	/// This is a normal connection except it contains a Lock method that
-	/// can be used to serialize access to the database.
+	/// can be used to serialize access to the database
+	/// in lieu of using the sqlite's FullMutex support.
 	/// </summary>
 	public class SQLiteConnectionWithLock : SQLiteConnection
 	{