diff --git a/Cargo.lock b/Cargo.lock
index 174e14a..89f9858 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -62,12 +62,6 @@ version = "0.1.2"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "597bb81c80a54b6a4381b23faba8d7774b144c94cbd1d6fe3f1329bd776554ab"
 
-[[package]]
-name = "bitflags"
-version = "2.6.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "b048fb63fd8b5923fc5aa7b340d8e156aec7ec02f0c78fa8a6ddc2613f6f71de"
-
 [[package]]
 name = "buffer-redux"
 version = "1.0.2"
@@ -258,6 +252,12 @@ version = "0.4.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "95505c38b4572b2d910cecb0281560f54b440a19336cbbcb27bf6ce6adc6f5a8"
 
+[[package]]
+name = "heck"
+version = "0.5.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "2304e00983f87ffb38b55b444b5e3b60a884b5d30c0fca7d82fe33449bbe55ea"
+
 [[package]]
 name = "histogram"
 version = "0.11.0"
@@ -292,9 +292,9 @@ dependencies = [
 
 [[package]]
 name = "indoc"
-version = "1.0.9"
+version = "2.0.5"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "bfa799dd5ed20a7e349f3b4639aa80d74549c81716d9ec4f994c9b5815598306"
+checksum = "b248f5224d1d606005e02c97f5aa4e88eeb230488bcc03bc9ca4d7991399f2b5"
 
 [[package]]
 name = "inplace-vec-builder"
@@ -356,16 +356,6 @@ version = "0.2.8"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "4ec2a862134d2a7d32d7983ddcdd1c4923530833c9f2ea1a44fc5fa473989058"
 
-[[package]]
-name = "lock_api"
-version = "0.4.12"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "07af8b9cdd281b7915f413fa73f29ebd5d55d0d3f0155584dade1ff18cea1b17"
-dependencies = [
- "autocfg",
- "scopeguard",
-]
-
 [[package]]
 name = "log"
 version = "0.4.22"
@@ -556,7 +546,7 @@ version = "0.18.4"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "39b0deead1528fd0e5947a8546a9642a9777c25f6e1e26f34c97b204bbb465bd"
 dependencies = [
- "heck",
+ "heck 0.4.1",
  "itertools 0.12.1",
  "proc-macro2",
  "proc-macro2-diagnostics",
@@ -573,29 +563,6 @@ dependencies = [
  "sourmash",
 ]
 
-[[package]]
-name = "parking_lot"
-version = "0.12.3"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "f1bf18183cf54e8d6059647fc3063646a1801cf30896933ec2311622cc4b9a27"
-dependencies = [
- "lock_api",
- "parking_lot_core",
-]
-
-[[package]]
-name = "parking_lot_core"
-version = "0.9.10"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "1e401f977ab385c9e4e3ab30627d6f26d00e2c73eef317493c4ec6d468726cf8"
-dependencies = [
- "cfg-if",
- "libc",
- "redox_syscall",
- "smallvec",
- "windows-targets",
-]
-
 [[package]]
 name = "paste"
 version = "1.0.15"
@@ -618,6 +585,12 @@ dependencies = [
  "thiserror",
 ]
 
+[[package]]
+name = "portable-atomic"
+version = "1.7.0"
+source = "registry+https://github.com/rust-lang/crates.io-index"
+checksum = "da544ee218f0d287a911e9c99a39a8c9bc8fcad3cb8db5959940044ecfc67265"
+
 [[package]]
 name = "ppv-lite86"
 version = "0.2.20"
@@ -684,16 +657,17 @@ dependencies = [
 
 [[package]]
 name = "pyo3"
-version = "0.19.2"
+version = "0.22.2"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "e681a6cfdc4adcc93b4d3cf993749a4552018ee0a9b65fc0ccfad74352c72a38"
+checksum = "831e8e819a138c36e212f3af3fd9eeffed6bf1510a805af35b0edee5ffa59433"
 dependencies = [
  "anyhow",
  "cfg-if",
  "indoc",
  "libc",
  "memoffset",
- "parking_lot",
+ "once_cell",
+ "portable-atomic",
  "pyo3-build-config",
  "pyo3-ffi",
  "pyo3-macros",
@@ -702,9 +676,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-build-config"
-version = "0.19.2"
+version = "0.22.2"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "076c73d0bc438f7a4ef6fdd0c3bb4732149136abd952b110ac93e4edb13a6ba5"
+checksum = "1e8730e591b14492a8945cdff32f089250b05f5accecf74aeddf9e8272ce1fa8"
 dependencies = [
  "once_cell",
  "target-lexicon",
@@ -712,9 +686,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-ffi"
-version = "0.19.2"
+version = "0.22.2"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "e53cee42e77ebe256066ba8aa77eff722b3bb91f3419177cf4cd0f304d3284d9"
+checksum = "5e97e919d2df92eb88ca80a037969f44e5e70356559654962cbb3316d00300c6"
 dependencies = [
  "libc",
  "pyo3-build-config",
@@ -722,25 +696,27 @@ dependencies = [
 
 [[package]]
 name = "pyo3-macros"
-version = "0.19.2"
+version = "0.22.2"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "dfeb4c99597e136528c6dd7d5e3de5434d1ceaf487436a3f03b2d56b6fc9efd1"
+checksum = "eb57983022ad41f9e683a599f2fd13c3664d7063a3ac5714cae4b7bee7d3f206"
 dependencies = [
  "proc-macro2",
  "pyo3-macros-backend",
  "quote",
- "syn 1.0.109",
+ "syn 2.0.77",
 ]
 
 [[package]]
 name = "pyo3-macros-backend"
-version = "0.19.2"
+version = "0.22.2"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "947dc12175c254889edc0c02e399476c2f652b4b9ebd123aa655c224de259536"
+checksum = "ec480c0c51ddec81019531705acac51bcdbeae563557c982aa8263bb96880372"
 dependencies = [
+ "heck 0.5.0",
  "proc-macro2",
+ "pyo3-build-config",
  "quote",
- "syn 1.0.109",
+ "syn 2.0.77",
 ]
 
 [[package]]
@@ -798,15 +774,6 @@ version = "0.2.1"
 source = "registry+https://github.com/rust-lang/crates.io-index"
 checksum = "60a357793950651c4ed0f3f52338f53b2f809f32d83a07f72909fa13e4c6c1e3"
 
-[[package]]
-name = "redox_syscall"
-version = "0.5.3"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "2a908a6e00f1fdd0dfd9c0eb08ce85126f6d8bbda50017e74bc4a4b7d4a926a4"
-dependencies = [
- "bitflags",
-]
-
 [[package]]
 name = "roaring"
 version = "0.10.6"
@@ -838,12 +805,6 @@ dependencies = [
  "bytemuck",
 ]
 
-[[package]]
-name = "scopeguard"
-version = "1.2.0"
-source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "94143f37725109f92c262ed2cf5e59bce7498c01bcc1502d7b9afe439a4e9f49"
-
 [[package]]
 name = "serde"
 version = "1.0.209"
@@ -1073,9 +1034,9 @@ checksum = "3354b9ac3fae1ff6755cb6db53683adb661634f67557942dea4facebec0fee4b"
 
 [[package]]
 name = "unindent"
-version = "0.1.11"
+version = "0.2.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "e1766d682d402817b5ac4490b3c3002d91dfa0d22812f341609f97b08757359c"
+checksum = "c7de7d73e1754487cb58364ee906a499937a0dfabd86bcb980fa99ec8c8fa2ce"
 
 [[package]]
 name = "vec-collections"
diff --git a/Cargo.toml b/Cargo.toml
index b07f19d..d23f187 100644
--- a/Cargo.toml
+++ b/Cargo.toml
@@ -9,6 +9,6 @@ name = "oxli"
 crate-type = ["cdylib"]
 
 [dependencies]
-pyo3 = { version="0.19.0", features = ["extension-module", "anyhow"] }
+pyo3 = { version="0.22.2", features = ["extension-module", "anyhow"] }
 sourmash = "0.15.1"
 anyhow = "1.0.86"
diff --git a/src/lib.rs b/src/lib.rs
index 61b1444..5cc9322 100644
--- a/src/lib.rs
+++ b/src/lib.rs
@@ -120,7 +120,7 @@ impl KmerCountTable {
 }
 
 #[pymodule]
-fn oxli(_py: Python, m: &PyModule) -> PyResult<()> {
+fn oxli(m: &Bound<'_, PyModule>) -> PyResult<()> {
     m.add_class::<KmerCountTable>()?;
     Ok(())
 }