diff --git a/instrumentation/README.md b/instrumentation/README.md
index c3d5262bb6..fb601266ea 100644
--- a/instrumentation/README.md
+++ b/instrumentation/README.md
@@ -39,7 +39,7 @@
 | [opentelemetry-instrumentation-redis](./opentelemetry-instrumentation-redis) | redis >= 2.6 | No | experimental
 | [opentelemetry-instrumentation-remoulade](./opentelemetry-instrumentation-remoulade) | remoulade >= 0.50 | No | experimental
 | [opentelemetry-instrumentation-requests](./opentelemetry-instrumentation-requests) | requests ~= 2.0 | Yes | migration
-| [opentelemetry-instrumentation-sqlalchemy](./opentelemetry-instrumentation-sqlalchemy) | sqlalchemy >= 1.0.0, < 2.0.0 | Yes | experimental
+| [opentelemetry-instrumentation-sqlalchemy](./opentelemetry-instrumentation-sqlalchemy) | sqlalchemy >= 1.0.0, < 2.1.0 | Yes | experimental
 | [opentelemetry-instrumentation-sqlite3](./opentelemetry-instrumentation-sqlite3) | sqlite3 | No | experimental
 | [opentelemetry-instrumentation-starlette](./opentelemetry-instrumentation-starlette) | starlette ~= 0.13.0 | Yes | experimental
 | [opentelemetry-instrumentation-system-metrics](./opentelemetry-instrumentation-system-metrics) | psutil >= 5 | No | experimental
diff --git a/instrumentation/opentelemetry-instrumentation-sqlalchemy/pyproject.toml b/instrumentation/opentelemetry-instrumentation-sqlalchemy/pyproject.toml
index 37be575965..d6d8c7aff9 100644
--- a/instrumentation/opentelemetry-instrumentation-sqlalchemy/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-sqlalchemy/pyproject.toml
@@ -34,7 +34,7 @@ dependencies = [
 
 [project.optional-dependencies]
 instruments = [
-  "sqlalchemy >= 1.0.0, < 2.0.0",
+  "sqlalchemy >= 1.0.0, < 2.1.0",
 ]
 
 [project.entry-points.opentelemetry_instrumentor]
diff --git a/instrumentation/opentelemetry-instrumentation-sqlalchemy/src/opentelemetry/instrumentation/sqlalchemy/package.py b/instrumentation/opentelemetry-instrumentation-sqlalchemy/src/opentelemetry/instrumentation/sqlalchemy/package.py
index 322e8302bc..77b148e51c 100644
--- a/instrumentation/opentelemetry-instrumentation-sqlalchemy/src/opentelemetry/instrumentation/sqlalchemy/package.py
+++ b/instrumentation/opentelemetry-instrumentation-sqlalchemy/src/opentelemetry/instrumentation/sqlalchemy/package.py
@@ -12,6 +12,6 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-_instruments = ("sqlalchemy >= 1.0.0, < 2.0.0",)
+_instruments = ("sqlalchemy >= 1.0.0, < 2.1.0",)
 
 _supports_metrics = True
diff --git a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py
index 04a596d4e7..2e7b5532f3 100644
--- a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py
+++ b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap_gen.py
@@ -161,7 +161,7 @@
         "instrumentation": "opentelemetry-instrumentation-requests==0.50b0.dev",
     },
     {
-        "library": "sqlalchemy >= 1.0.0, < 2.0.0",
+        "library": "sqlalchemy >= 1.0.0, < 2.1.0",
         "instrumentation": "opentelemetry-instrumentation-sqlalchemy==0.50b0.dev",
     },
     {