diff --git a/src/ontology/components/obsoletes.owl b/src/ontology/components/obsoletes.owl
index 6a007ebd..62431f95 100644
--- a/src/ontology/components/obsoletes.owl
+++ b/src/ontology/components/obsoletes.owl
@@ -7,8 +7,8 @@ Prefix(rdfs:=<http://www.w3.org/2000/01/rdf-schema#>)
 
 
 Ontology(<http://purl.obolibrary.org/obo/oba/components/obsoletes.owl>
-<http://purl.obolibrary.org/obo/oba/releases/2024-01-12/components/obsoletes.owl>
-Annotation(owl:versionInfo "2024-01-12")
+<http://purl.obolibrary.org/obo/oba/releases/2024-04-26/components/obsoletes.owl>
+Annotation(owl:versionInfo "2024-04-26")
 
 Declaration(Class(<http://purl.obolibrary.org/obo/OBA_0000037>))
 Declaration(Class(<http://purl.obolibrary.org/obo/OBA_0000039>))
diff --git a/src/ontology/components/synonyms.owl b/src/ontology/components/synonyms.owl
index 850f5d95..a7657f7c 100644
--- a/src/ontology/components/synonyms.owl
+++ b/src/ontology/components/synonyms.owl
@@ -7,8 +7,8 @@ Prefix(rdfs:=<http://www.w3.org/2000/01/rdf-schema#>)
 
 
 Ontology(<http://purl.obolibrary.org/obo/oba/components/synonyms.owl>
-<http://purl.obolibrary.org/obo/oba/releases/2024-01-12/components/synonyms.owl>
-Annotation(owl:versionInfo "2024-01-12")
+<http://purl.obolibrary.org/obo/oba/releases/2024-04-26/components/synonyms.owl>
+Annotation(owl:versionInfo "2024-04-26")
 
 Declaration(Class(<http://purl.obolibrary.org/obo/OBA_0002546>))
 Declaration(Class(<http://purl.obolibrary.org/obo/OBA_0002565>))
diff --git a/src/ontology/imports/merged_import.owl b/src/ontology/imports/merged_import.owl
index 6f72f6e0..353ac233 100644
--- a/src/ontology/imports/merged_import.owl
+++ b/src/ontology/imports/merged_import.owl
@@ -7,8 +7,8 @@ Prefix(rdfs:=<http://www.w3.org/2000/01/rdf-schema#>)
 
 
 Ontology(<http://purl.obolibrary.org/obo/oba/imports/merged_import.owl>
-<http://purl.obolibrary.org/obo/oba/releases/2024-05-08/imports/merged_import.owl>
-Annotation(owl:versionInfo "2024-05-08")
+<http://purl.obolibrary.org/obo/oba/releases/2024-05-09/imports/merged_import.owl>
+Annotation(owl:versionInfo "2024-05-09")
 
 Declaration(Class(<http://purl.obolibrary.org/obo/BFO_0000001>))
 Declaration(Class(<http://purl.obolibrary.org/obo/BFO_0000002>))
@@ -882,6 +882,7 @@ Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_25036>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_25046>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_25094>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_25095>))
+Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_25105>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_25106>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_25107>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_25108>))
@@ -1544,6 +1545,7 @@ Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_33637>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_33641>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_33645>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_33653>))
+Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_33654>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_33655>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_33658>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_33659>))
@@ -1856,6 +1858,8 @@ Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_36059>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_36064>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_36078>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_36080>))
+Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_36132>))
+Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_36140>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_36141>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_36145>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_36147>))
@@ -1983,6 +1987,7 @@ Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_37240>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_37246>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_37247>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_37253>))
+Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_3732>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_37332>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_37395>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_37396>))
@@ -3177,7 +3182,9 @@ Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_76014>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_76042>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_76079>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_76170>))
+Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_76172>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_76194>))
+Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_76199>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_76206>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_76224>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_76273>))
@@ -23000,6 +23007,7 @@ Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0003931>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0003932>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0003933>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0003934>))
+Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0003936>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0003937>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0003939>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0003950>))
@@ -23343,6 +23351,7 @@ Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0005590>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0005593>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0005595>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0005605>))
+Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0005606>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0005607>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0005611>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0005613>))
@@ -23399,6 +23408,7 @@ Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0006029>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0006030>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0006031>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0006032>))
+Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0006035>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0006036>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0006040>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0006041>))
@@ -23634,7 +23644,6 @@ Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0015925>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0015962>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0015967>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0015978>))
-Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0015979>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0016047>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0016094>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MONDO_0016105>))
@@ -52769,7 +52778,7 @@ AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/RO_0004023> "caus
 SubObjectPropertyOf(<http://purl.obolibrary.org/obo/RO_0004023> <http://purl.obolibrary.org/obo/RO_0002410>)
 SubObjectPropertyOf(<http://purl.obolibrary.org/obo/RO_0004023> <http://purl.obolibrary.org/obo/RO_0040035>)
 
-# Object Property: <http://purl.obolibrary.org/obo/RO_0004024> (disease disrupts)
+# Object Property: <http://purl.obolibrary.org/obo/RO_0004024> (disease causes disruption of)
 
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/RO_0004024> "A relationship between a disease and a process where the disease process disrupts the execution of the process.")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/RO_0004024> "disease causes disruption of")
@@ -60258,6 +60267,13 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_25095> <http://purl.obolibrary.
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_25095> <http://purl.obolibrary.org/obo/CHEBI_83811>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_25095> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#has_functional_parent> <http://purl.obolibrary.org/obo/CHEBI_18019>))
 
+# Class: <http://purl.obolibrary.org/obo/CHEBI_25105> (macrolide antibiotic)
+
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_25105> "A macrocyclic lactone with a ring of twelve or more members which exhibits antibiotic activity.")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_25105> "macrolide antibiotic")
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_25105> <http://purl.obolibrary.org/obo/CHEBI_25106>)
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_25105> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_33281>))
+
 # Class: <http://purl.obolibrary.org/obo/CHEBI_25106> (macrolide)
 
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_25106> "A macrocyclic lactone with a ring of twelve or more members derived from a polyketide.")
@@ -65345,6 +65361,13 @@ AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.ob
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_33653> "aliphatic compound")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33653> <http://purl.obolibrary.org/obo/CHEBI_50860>)
 
+# Class: <http://purl.obolibrary.org/obo/CHEBI_33654> (alicyclic compound)
+
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_33654> "An aliphatic compound having a carbocyclic ring structure which may be saturated or unsaturated, but may not be a benzenoid or other aromatic system.")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_33654> "alicyclic compound")
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33654> <http://purl.obolibrary.org/obo/CHEBI_33598>)
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_33654> <http://purl.obolibrary.org/obo/CHEBI_33653>)
+
 # Class: <http://purl.obolibrary.org/obo/CHEBI_33655> (aromatic compound)
 
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_33655> "A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character.")
@@ -67425,6 +67448,19 @@ EquivalentClasses(<http://purl.obolibrary.org/obo/CHEBI_36080> <http://purl.obol
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_36080> <http://purl.obolibrary.org/obo/CHEBI_33695>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_36080> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> <http://purl.obolibrary.org/obo/CHEBI_16541>))
 
+# Class: <http://purl.obolibrary.org/obo/CHEBI_36132> (alicyclic ketone)
+
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_36132> "A cyclic ketone in which the carbocyclic ring structure which may be saturated or unsaturated, but may not be a benzenoid or other aromatic system.")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_36132> "alicyclic ketone")
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_36132> <http://purl.obolibrary.org/obo/CHEBI_3992>)
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_36132> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#has_parent_hydride> <http://purl.obolibrary.org/obo/CHEBI_33654>))
+
+# Class: <http://purl.obolibrary.org/obo/CHEBI_36140> (cyclopentanones)
+
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_36140> "Any alicyclic ketone that consists of a cyclopentane skeleton substituted by at least one oxo group.")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_36140> "cyclopentanones")
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_36140> <http://purl.obolibrary.org/obo/CHEBI_36132>)
+
 # Class: <http://purl.obolibrary.org/obo/CHEBI_36141> (quinone)
 
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_36141> "Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included).")
@@ -68243,6 +68279,16 @@ SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_37247> <http://purl.obolibrary.
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_37253> "elemental zinc")
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_37253> <http://purl.obolibrary.org/obo/CHEBI_27364>)
 
+# Class: <http://purl.obolibrary.org/obo/CHEBI_3732> (clarithromycin)
+
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_3732> "The 6-O-methyl ether of erythromycin A, clarithromycin is a macrolide antibiotic used in the treatment of respiratory-tract, skin and soft-tissue infections. It is also used to eradicate Helicobacter pylori in the treatment of peptic ulcer disease. It prevents bacteria from growing by interfering with their protein synthesis.")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_3732> "clarithromycin")
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_3732> <http://purl.obolibrary.org/obo/CHEBI_25105>)
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_3732> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_35703>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_3732> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_36047>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_3732> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_48001>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_3732> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_78298>))
+
 # Class: <http://purl.obolibrary.org/obo/CHEBI_37332> (tropane alkaloid)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_37332> "tropane alkaloid")
@@ -76871,6 +76917,20 @@ AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_76170> "ole
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_76170> <http://purl.obolibrary.org/obo/CHEBI_16247>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_76170> <http://purl.obolibrary.org/obo/CHEBI_78840>)
 
+# Class: <http://purl.obolibrary.org/obo/CHEBI_76172> (loxoprofen)
+
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_76172> "A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-[(2-oxocyclopentyl)methyl]phenyl group. A prodrug that is rapidly converted into its active trans-alcohol metabolite following oral administration.")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_76172> "loxoprofen")
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_76172> <http://purl.obolibrary.org/obo/CHEBI_25384>)
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_76172> <http://purl.obolibrary.org/obo/CHEBI_36140>)
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_76172> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_35475>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_76172> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_35481>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_76172> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_35493>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_76172> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_35544>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_76172> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_50266>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_76172> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#has_functional_parent> <http://purl.obolibrary.org/obo/CHEBI_30768>))
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_76172> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of> <http://purl.obolibrary.org/obo/CHEBI_76199>))
+
 # Class: <http://purl.obolibrary.org/obo/CHEBI_76194> (palmitoyl bioconjugate)
 
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_76194> "A bioconjugate obtained by coupling of palmitic acid to another biomolecule (e.g. coenzyme A, an acyl-carrier protein, a phospholipid, an oligosaccharide, a nucleic acid etc.), which for the sake of convenience, is represented by an R group.")
@@ -76878,6 +76938,13 @@ AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_76194> "pal
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_76194> <http://purl.obolibrary.org/obo/CHEBI_64985>)
 SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_76194> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#has_functional_parent> <http://purl.obolibrary.org/obo/CHEBI_15756>))
 
+# Class: <http://purl.obolibrary.org/obo/CHEBI_76199> (loxoprofen(1-))
+
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_76199> "An oxo monocarboxylic acid anion that is the conjugate base of loxoprofen, obtained by deprotonation of the carboxy group.")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/CHEBI_76199> "loxoprofen(1-)")
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_76199> <http://purl.obolibrary.org/obo/CHEBI_35902>)
+SubClassOf(<http://purl.obolibrary.org/obo/CHEBI_76199> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of> <http://purl.obolibrary.org/obo/CHEBI_76172>))
+
 # Class: <http://purl.obolibrary.org/obo/CHEBI_76206> (xenobiotic metabolite)
 
 AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/CHEBI_76206> "Any metabolite produced by metabolism of a xenobiotic compound.")
@@ -226788,6 +226855,13 @@ EquivalentClasses(<http://purl.obolibrary.org/obo/MONDO_0003934> ObjectIntersect
 SubClassOf(<http://purl.obolibrary.org/obo/MONDO_0003934> <http://purl.obolibrary.org/obo/MONDO_0003214>)
 SubClassOf(<http://purl.obolibrary.org/obo/MONDO_0003934> <http://purl.obolibrary.org/obo/MONDO_0005590>)
 
+# Class: <http://purl.obolibrary.org/obo/MONDO_0003936> (invasive tubular breast carcinoma)
+
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MONDO_0003936> "invasive tubular breast carcinoma")
+EquivalentClasses(<http://purl.obolibrary.org/obo/MONDO_0003936> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/MONDO_0005606> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000053> <http://purl.obolibrary.org/obo/PATO_0002129>) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0004026> <http://purl.obolibrary.org/obo/UBERON_0000310>)))
+SubClassOf(<http://purl.obolibrary.org/obo/MONDO_0003936> <http://purl.obolibrary.org/obo/MONDO_0004953>)
+SubClassOf(<http://purl.obolibrary.org/obo/MONDO_0003936> <http://purl.obolibrary.org/obo/MONDO_0005606>)
+
 # Class: <http://purl.obolibrary.org/obo/MONDO_0003937> (spondylitis)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MONDO_0003937> "spondylitis")
@@ -228521,7 +228595,8 @@ SubClassOf(<http://purl.obolibrary.org/obo/MONDO_0005180> <http://purl.obolibrar
 # Class: <http://purl.obolibrary.org/obo/MONDO_0005184> (pancreatic ductal adenocarcinoma)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MONDO_0005184> "pancreatic ductal adenocarcinoma")
-EquivalentClasses(<http://purl.obolibrary.org/obo/MONDO_0005184> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/MONDO_0004970> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0004026> <http://purl.obolibrary.org/obo/UBERON_0007329>)))
+EquivalentClasses(<http://purl.obolibrary.org/obo/MONDO_0005184> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/MONDO_0005606> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0004026> <http://purl.obolibrary.org/obo/UBERON_0007329>)))
+SubClassOf(<http://purl.obolibrary.org/obo/MONDO_0005184> <http://purl.obolibrary.org/obo/MONDO_0005606>)
 SubClassOf(<http://purl.obolibrary.org/obo/MONDO_0005184> <http://purl.obolibrary.org/obo/MONDO_0006047>)
 SubClassOf(<http://purl.obolibrary.org/obo/MONDO_0005184> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0004026> <http://purl.obolibrary.org/obo/UBERON_0007329>))
 
@@ -229294,6 +229369,11 @@ SubClassOf(<http://purl.obolibrary.org/obo/MONDO_0005605> <http://purl.obolibrar
 SubClassOf(<http://purl.obolibrary.org/obo/MONDO_0005605> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0004030> <http://purl.obolibrary.org/obo/CL_1001428>))
 SubClassOf(<http://purl.obolibrary.org/obo/MONDO_0005605> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0004030> <http://purl.obolibrary.org/obo/UBERON_0004645>))
 
+# Class: <http://purl.obolibrary.org/obo/MONDO_0005606> (tubular adenocarcinoma)
+
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MONDO_0005606> "tubular adenocarcinoma")
+SubClassOf(<http://purl.obolibrary.org/obo/MONDO_0005606> <http://purl.obolibrary.org/obo/MONDO_0004970>)
+
 # Class: <http://purl.obolibrary.org/obo/MONDO_0005607> (chronic bronchitis)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MONDO_0005607> "chronic bronchitis")
@@ -229725,6 +229805,13 @@ SubClassOf(<http://purl.obolibrary.org/obo/MONDO_0006032> <http://purl.obolibrar
 SubClassOf(<http://purl.obolibrary.org/obo/MONDO_0006032> <http://purl.obolibrary.org/obo/MONDO_0021166>)
 SubClassOf(<http://purl.obolibrary.org/obo/MONDO_0006032> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0004027> <http://purl.obolibrary.org/obo/UBERON_0001255>))
 
+# Class: <http://purl.obolibrary.org/obo/MONDO_0006035> (gastric tubular adenocarcinoma)
+
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MONDO_0006035> "gastric tubular adenocarcinoma")
+EquivalentClasses(<http://purl.obolibrary.org/obo/MONDO_0006035> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/MONDO_0005606> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0004026> <http://purl.obolibrary.org/obo/UBERON_0000945>)))
+SubClassOf(<http://purl.obolibrary.org/obo/MONDO_0006035> <http://purl.obolibrary.org/obo/MONDO_0005036>)
+SubClassOf(<http://purl.obolibrary.org/obo/MONDO_0006035> <http://purl.obolibrary.org/obo/MONDO_0005606>)
+
 # Class: <http://purl.obolibrary.org/obo/MONDO_0006036> (granulosa cell tumor)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MONDO_0006036> "granulosa cell tumor")
@@ -231466,14 +231553,6 @@ EquivalentClasses(<http://purl.obolibrary.org/obo/MONDO_0015978> ObjectIntersect
 SubClassOf(<http://purl.obolibrary.org/obo/MONDO_0015978> <http://purl.obolibrary.org/obo/MONDO_0004805>)
 SubClassOf(<http://purl.obolibrary.org/obo/MONDO_0015978> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0004020> <http://purl.obolibrary.org/obo/CL_0000775>))
 
-# Class: <http://purl.obolibrary.org/obo/MONDO_0015979> (hereditary predisposition to infections)
-
-AnnotationAssertion(rdfs:comment <http://purl.obolibrary.org/obo/MONDO_0015979> "Reason: out of scope. MONDO:excludeGrouping. Term to consider:MONDO:0020573 inherited disease susceptibility")
-AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MONDO_0015979> "hereditary predisposition to infections")
-EquivalentClasses(<http://purl.obolibrary.org/obo/MONDO_0015979> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/MONDO_0020573> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/mondo#predisposes_towards> <http://purl.obolibrary.org/obo/MONDO_0005550>)))
-SubClassOf(<http://purl.obolibrary.org/obo/MONDO_0015979> <http://purl.obolibrary.org/obo/MONDO_0020573>)
-SubClassOf(<http://purl.obolibrary.org/obo/MONDO_0015979> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/mondo#predisposes_towards> <http://purl.obolibrary.org/obo/MONDO_0005550>))
-
 # Class: <http://purl.obolibrary.org/obo/MONDO_0016047> (endophthalmitis)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MONDO_0016047> "endophthalmitis")
@@ -232411,8 +232490,8 @@ SubClassOf(<http://purl.obolibrary.org/obo/MONDO_0019127> <http://purl.obolibrar
 # Class: <http://purl.obolibrary.org/obo/MONDO_0019146> (inherited susceptibility to mycobacterial diseases)
 
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MONDO_0019146> "inherited susceptibility to mycobacterial diseases")
-EquivalentClasses(<http://purl.obolibrary.org/obo/MONDO_0019146> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/MONDO_0015979> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0014001> <http://purl.obolibrary.org/obo/NCBITaxon_1763>)))
-SubClassOf(<http://purl.obolibrary.org/obo/MONDO_0019146> <http://purl.obolibrary.org/obo/MONDO_0015979>)
+EquivalentClasses(<http://purl.obolibrary.org/obo/MONDO_0019146> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/MONDO_0020573> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0014001> <http://purl.obolibrary.org/obo/NCBITaxon_1763>)))
+SubClassOf(<http://purl.obolibrary.org/obo/MONDO_0019146> <http://purl.obolibrary.org/obo/MONDO_0020573>)
 SubClassOf(<http://purl.obolibrary.org/obo/MONDO_0019146> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0014001> <http://purl.obolibrary.org/obo/NCBITaxon_1763>))
 
 # Class: <http://purl.obolibrary.org/obo/MONDO_0019182> (inherited obesity)
diff --git a/src/patterns/data/default/response_to_chemical_stimulus_trait.tsv b/src/patterns/data/default/response_to_chemical_stimulus_trait.tsv
index 36073eef..81071fad 100644
--- a/src/patterns/data/default/response_to_chemical_stimulus_trait.tsv
+++ b/src/patterns/data/default/response_to_chemical_stimulus_trait.tsv
@@ -117,3 +117,5 @@ OBA:2050330		CHEBI:135983	teriparatide	https://orcid.org/0000-0001-6757-4744
 OBA:2050333		CHEBI:31941	oxaliplatin	https://orcid.org/0000-0001-6757-4744
 OBA:2045298		CHEBI:145810	insulin	https://orcid.org/0000-0001-8314-2140
 OBA:2045299		CHEBI:17234	glucose	https://orcid.org/0000-0001-8314-2140
+OBA:2050420		CHEBI:76172	loxoprofen	https://orcid.org/0000-0001-6757-4744
+OBA:2050421		CHEBI:3732	clarithromycin	https://orcid.org/0000-0001-6757-4744
diff --git a/src/patterns/definitions.owl b/src/patterns/definitions.owl
index 0ee7da40..79ce14e8 100644
--- a/src/patterns/definitions.owl
+++ b/src/patterns/definitions.owl
@@ -7,8 +7,8 @@ Prefix(rdfs:=<http://www.w3.org/2000/01/rdf-schema#>)
 
 
 Ontology(<http://purl.obolibrary.org/obo/oba/patterns/definitions.owl>
-<http://purl.obolibrary.org/obo/oba/releases/2024-05-08/patterns/definitions.owl>
-Annotation(owl:versionInfo "2024-05-08")
+<http://purl.obolibrary.org/obo/oba/releases/2024-05-09/patterns/definitions.owl>
+Annotation(owl:versionInfo "2024-05-09")
 
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_10033>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_10112>))
@@ -286,6 +286,7 @@ Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_36791>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_36796>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_36916>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_3723>))
+Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_3732>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_3766>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_37670>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_37733>))
@@ -434,6 +435,7 @@ Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_75998>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_76004>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_76010>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_76079>))
+Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_76172>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_76281>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_77096>))
 Declaration(Class(<http://purl.obolibrary.org/obo/CHEBI_77292>))
@@ -12641,6 +12643,8 @@ Declaration(Class(<http://purl.obolibrary.org/obo/OBA_2050416>))
 Declaration(Class(<http://purl.obolibrary.org/obo/OBA_2050417>))
 Declaration(Class(<http://purl.obolibrary.org/obo/OBA_2050418>))
 Declaration(Class(<http://purl.obolibrary.org/obo/OBA_2050419>))
+Declaration(Class(<http://purl.obolibrary.org/obo/OBA_2050420>))
+Declaration(Class(<http://purl.obolibrary.org/obo/OBA_2050421>))
 Declaration(Class(<http://purl.obolibrary.org/obo/OBA_2060000>))
 Declaration(Class(<http://purl.obolibrary.org/obo/OBA_2060001>))
 Declaration(Class(<http://purl.obolibrary.org/obo/OBA_2060002>))
@@ -105194,6 +105198,22 @@ AnnotationAssertion(Annotation(<http://www.geneontology.org/formats/oboInOwl#has
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/OBA_2050419> "level of endocrine disruptor in urine")
 EquivalentClasses(<http://purl.obolibrary.org/obo/OBA_2050419> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000070> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_24431> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000087> <http://purl.obolibrary.org/obo/CHEBI_138015>)) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001088>)))))
 
+# Class: <http://purl.obolibrary.org/obo/OBA_2050420> (trait in response to loxoprofen)
+
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/OBA_2050420> "A trait that affects the response to a stimulus with loxoprofen.")
+AnnotationAssertion(<http://purl.org/dc/terms/contributor> <http://purl.obolibrary.org/obo/OBA_2050420> "https://orcid.org/0000-0001-6757-4744")
+AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/OBA_2050420> "response to loxoprofen trait")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/OBA_2050420> "trait in response to loxoprofen")
+EquivalentClasses(<http://purl.obolibrary.org/obo/OBA_2050420> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0001236> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/GO_0050896> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002233> <http://purl.obolibrary.org/obo/CHEBI_76172>)))))
+
+# Class: <http://purl.obolibrary.org/obo/OBA_2050421> (trait in response to clarithromycin)
+
+AnnotationAssertion(<http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/OBA_2050421> "A trait that affects the response to a stimulus with clarithromycin.")
+AnnotationAssertion(<http://purl.org/dc/terms/contributor> <http://purl.obolibrary.org/obo/OBA_2050421> "https://orcid.org/0000-0001-6757-4744")
+AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/OBA_2050421> "response to clarithromycin trait")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/OBA_2050421> "trait in response to clarithromycin")
+EquivalentClasses(<http://purl.obolibrary.org/obo/OBA_2050421> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0001236> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/GO_0050896> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002233> <http://purl.obolibrary.org/obo/CHEBI_3732>)))))
+
 # Class: <http://purl.obolibrary.org/obo/OBA_2060000> (aggressive behavior towards inanimate objects rate)
 
 AnnotationAssertion(Annotation(<http://www.geneontology.org/formats/oboInOwl#hasDbXref> "AUTO:patterns/patterns/entity_attribute") <http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/OBA_2060000> "The rate of a aggressive behavior towards inanimate objects.")