From d4dde8dc19cb6f8b80b3ce2d66f8fc3870637b86 Mon Sep 17 00:00:00 2001 From: Peter Winskill Date: Tue, 28 Feb 2023 11:19:30 +0000 Subject: [PATCH 01/28] Add option for distribution day to be specified for itns --- R/interventions.R | 7 +++++-- 1 file changed, 5 insertions(+), 2 deletions(-) diff --git a/R/interventions.R b/R/interventions.R index b55bf4d..d2c0016 100644 --- a/R/interventions.R +++ b/R/interventions.R @@ -108,8 +108,11 @@ add_treatment <- function(p, interventions){ #' #' @return modified parameter list add_itns <- function(p, interventions){ - # Assuming net distribution happens on January 1st - timesteps <- 1 + (interventions$year - p$baseline_year) * 365 + + if(!"itn_distribution_day" %in% colnames(interventions)){ + interventions$itn_distribution_day <- 1 + } + timesteps <- interventions$itn_distribution_day + (interventions$year - p$baseline_year) * 365 # Net retention half life does not vary over time (Should match what is used when fitting input dist) retention <- 365 * 5 # Net input coverage From f9e2d340d269d1bd66eb31da750dae2952bd15db Mon Sep 17 00:00:00 2001 From: Peter Winskill Date: Tue, 28 Feb 2023 11:25:29 +0000 Subject: [PATCH 02/28] Allow for specific ITN distribution timing --- DESCRIPTION | 2 +- R/interventions.R | 1 + 2 files changed, 2 insertions(+), 1 deletion(-) diff --git a/DESCRIPTION b/DESCRIPTION index a88819a..b1280e4 100644 --- a/DESCRIPTION +++ b/DESCRIPTION @@ -1,7 +1,7 @@ Package: site Type: Package Title: Site specific malariasimulation modelling -Version: 0.2.2 +Version: 0.2.3 Authors@R: c( person("Pete", "Winskill", email = "p.winskill@imperial.ac.uk", role = c("aut", "cre")) ) diff --git a/R/interventions.R b/R/interventions.R index d2c0016..495ad84 100644 --- a/R/interventions.R +++ b/R/interventions.R @@ -109,6 +109,7 @@ add_treatment <- function(p, interventions){ #' @return modified parameter list add_itns <- function(p, interventions){ + # If not specified, assume distribution happens January 1st if(!"itn_distribution_day" %in% colnames(interventions)){ interventions$itn_distribution_day <- 1 } From cd5674d8c062804f49ad5fc81d0fa12fc2e1706e Mon Sep 17 00:00:00 2001 From: Peter Winskill Date: Tue, 28 Feb 2023 12:38:08 +0000 Subject: [PATCH 03/28] Update workflow --- .github/workflows/check-standard.yaml | 2 +- .github/workflows/test-coverage.yaml | 2 +- 2 files changed, 2 insertions(+), 2 deletions(-) diff --git a/.github/workflows/check-standard.yaml b/.github/workflows/check-standard.yaml index a3ac618..9c45ee1 100644 --- a/.github/workflows/check-standard.yaml +++ b/.github/workflows/check-standard.yaml @@ -4,7 +4,7 @@ on: push: branches: [main, master] pull_request: - branches: [main, master] + branches: [main, master, dev] name: R-CMD-check diff --git a/.github/workflows/test-coverage.yaml b/.github/workflows/test-coverage.yaml index 2c5bb50..23171ad 100644 --- a/.github/workflows/test-coverage.yaml +++ b/.github/workflows/test-coverage.yaml @@ -4,7 +4,7 @@ on: push: branches: [main, master] pull_request: - branches: [main, master] + branches: [main, master, dev] name: test-coverage From 09a413a76b26677d3f2d6356822268e0905a2309 Mon Sep 17 00:00:00 2001 From: Peter Winskill Date: Thu, 2 Mar 2023 13:43:32 +0000 Subject: [PATCH 04/28] Burnin 0 coverage --- DESCRIPTION | 2 +- R/burnin.R | 13 ++++++++++++- man/burnin_interventions.Rd | 2 +- 3 files changed, 14 insertions(+), 3 deletions(-) diff --git a/DESCRIPTION b/DESCRIPTION index b1280e4..0b98a48 100644 --- a/DESCRIPTION +++ b/DESCRIPTION @@ -1,7 +1,7 @@ Package: site Type: Package Title: Site specific malariasimulation modelling -Version: 0.2.3 +Version: 0.2.4 Authors@R: c( person("Pete", "Winskill", email = "p.winskill@imperial.ac.uk", role = c("aut", "cre")) ) diff --git a/R/burnin.R b/R/burnin.R index 38fe53e..8585cc8 100644 --- a/R/burnin.R +++ b/R/burnin.R @@ -1,6 +1,6 @@ #' Expand interventions retrospectively for burn in period #' -#' Assumes interventions for burn in period are = to those in year 1. +#' Assumes interventions for burn in period are = 0 coverage. #' #' @param interventions Site intervention inputs #' @param burnin Burn in period (years) @@ -10,6 +10,17 @@ burnin_interventions <- function(interventions, burnin){ start_year <- min(interventions$year) - burnin interventions <- interventions |> tidyr::complete(year = start_year:(max(interventions$year))) |> + tidyr::replace_na( + replace = list( + itn_use = 0, + itn_input_dist = 0, + tx_cov = 0, + irs_cov = 0, + smc_cov = 0, + rtss_cov = 0, + pmc_cov = 0 + ) + ) |> tidyr::fill(dplyr::everything(), .direction = "up") return(interventions) } diff --git a/man/burnin_interventions.Rd b/man/burnin_interventions.Rd index 0038791..ecdaced 100644 --- a/man/burnin_interventions.Rd +++ b/man/burnin_interventions.Rd @@ -15,5 +15,5 @@ burnin_interventions(interventions, burnin) Intervention inputs with burn in } \description{ -Assumes interventions for burn in period are = to those in year 1. +Assumes interventions for burn in period are = 0 coverage. } From fc0ef990db1a54c05ea6366d7dc64fc91acc35d7 Mon Sep 17 00:00:00 2001 From: Peter Winskill Date: Mon, 13 Mar 2023 13:56:05 +0000 Subject: [PATCH 05/28] parse up to 2 IRs rounds --- R/interventions.R | 31 +++++++++++++++++++++---------- tests/testthat/test-irs.R | 36 ++++++++++++++++++++++++++++++++++++ 2 files changed, 57 insertions(+), 10 deletions(-) diff --git a/R/interventions.R b/R/interventions.R index 495ad84..6deb1a2 100644 --- a/R/interventions.R +++ b/R/interventions.R @@ -149,17 +149,28 @@ add_irs <- function(p, interventions){ month <- 365 / 12 peak <- malariasimulation::peak_season_offset(p) year_start_times <- 1 + (interventions$year - p$baseline_year) * 365 - peak_season_times <- peak + year_start_times - # Assume IRS occurs 3 months before seasonal peak - irs_spray_times <- round(peak_season_times - 3 * month) - coverages <- interventions$irs_cov - ls_theta <- interventions$ls_theta - ls_gamma <- interventions$ls_gamma - ks_theta <- interventions$ks_theta - ks_gamma <- interventions$ks_gamma - ms_theta <- interventions$ms_theta - ms_gamma <- interventions$ms_gamma + if(any(interventions$irs_spray_rounds > 2)){ + stop("Maximum of 2 IRS spray rounds per year supported") + } + + peak_season_times <- peak + year_start_times + peak_season_times <- rep(peak_season_times, interventions$irs_spray_rounds) + + # Assume multiple spray rounds are 6 months apart (First is 3 months prior to peak) + offset <- sapply(interventions$irs_spray_rounds, function(x){ + c(3, -3)[1:x] + }) |> + unlist() + irs_spray_times <- round(peak_season_times - offset * month) + + coverages <- rep(interventions$irs_cov, interventions$irs_spray_rounds) + ls_theta <- rep(interventions$ls_theta, interventions$irs_spray_rounds) + ls_gamma <- rep(interventions$ls_gamma, interventions$irs_spray_rounds) + ks_theta <- rep(interventions$ks_theta, interventions$irs_spray_rounds) + ks_gamma <- rep(interventions$ks_gamma, interventions$irs_spray_rounds) + ms_theta <- rep(interventions$ms_theta, interventions$irs_spray_rounds) + ms_gamma <- rep(interventions$ms_gamma, interventions$irs_spray_rounds) index <- irs_spray_times <= 0 if(sum(index) > 0){ diff --git a/tests/testthat/test-irs.R b/tests/testthat/test-irs.R index f1a8e3e..1892c51 100644 --- a/tests/testthat/test-irs.R +++ b/tests/testthat/test-irs.R @@ -62,3 +62,39 @@ test_that("adding irs works", { expect_equal(p1$spraying_ms_theta, matrix(interventions$ms_theta[!index], ncol = 1)) }) + +test_that("adding irs multiple rounds works", { + example_site <- single_site(example_site, 1) + interventions <- example_site$interventions + interventions$irs_spray_rounds[23] <- 2 + interventions$irs_cov[1:23] <- 0.5 + + p0 <- malariasimulation::get_parameters() + p0$baseline_year <- 2000 + p0 <- add_seasonality(p0, example_site$seasonality) + p0$g <- p0$g + 5 + p1 <- add_irs( + p = p0, + interventions = interventions + ) + + month <- 365 / 12 + peak <- malariasimulation::peak_season_offset(p1) + year_start_times <- 1 + (example_site$interventions$year - p1$baseline_year) * 365 + peak_season_times <- peak + year_start_times + # Assume IRS occurs 3 months before seasonal peak + timesteps <- round(peak_season_times - 3 * month) + timesteps <- round(c(timesteps, peak_season_times[length(peak_season_times)] + 3 * month)) + index <- timesteps < 0 + timesteps <- timesteps[!index] + + expect_equal(p1$spraying, TRUE) + expect_equal(p1$spraying_timesteps, timesteps) + expect_equal(p1$spraying_coverages, rep(interventions$irs_cov, interventions$irs_spray_rounds)[!index]) + expect_equal(p1$spraying_ls_theta, matrix(rep(interventions$ls_theta, interventions$irs_spray_rounds)[!index], ncol = 1)) + expect_equal(p1$spraying_ls_gamma, matrix(rep(interventions$ls_gamma, interventions$irs_spray_rounds)[!index], ncol = 1)) + expect_equal(p1$spraying_ks_theta, matrix(rep(interventions$ks_theta, interventions$irs_spray_rounds)[!index], ncol = 1)) + expect_equal(p1$spraying_ks_theta, matrix(rep(interventions$ks_theta, interventions$irs_spray_rounds)[!index], ncol = 1)) + expect_equal(p1$spraying_ms_theta, matrix(rep(interventions$ms_theta, interventions$irs_spray_rounds)[!index], ncol = 1)) + expect_equal(p1$spraying_ms_theta, matrix(rep(interventions$ms_theta, interventions$irs_spray_rounds)[!index], ncol = 1)) +}) From 81a4573ed403046d0f0e22ab3a551b810897c670 Mon Sep 17 00:00:00 2001 From: Peter Winskill Date: Fri, 21 Apr 2023 16:19:14 +0100 Subject: [PATCH 06/28] Generalise single site --- R/single_site.R | 15 ++++++++------- 1 file changed, 8 insertions(+), 7 deletions(-) diff --git a/R/single_site.R b/R/single_site.R index 8ca543c..57ada64 100644 --- a/R/single_site.R +++ b/R/single_site.R @@ -11,13 +11,14 @@ single_site <- function(site_file, index){ } index_site <- site_file$sites[index, ] - to_mod <- c("sites", "interventions", "pyrethroid_resistance", "population", - "vectors", "seasonality", "prevalence", "eir") - - site <- site_file - for(level in to_mod){ - mc <- intersect(colnames(index_site), colnames(site[[level]])) - site[[level]] <- dplyr::left_join(index_site, site[[level]], by = mc) + site <- list() + for(level in names(site_file)){ + mc <- intersect(colnames(index_site), colnames(site_file[[level]])) + if(length(mc) == 0){ + site[[level]] <- site_file[[level]] + } else { + site[[level]] <- dplyr::left_join(index_site, site_file[[level]], by = mc) + } } return(site) } From 49c109cd1fe9453944d5b27d340049b56f23018c Mon Sep 17 00:00:00 2001 From: Peter Winskill Date: Fri, 12 May 2023 12:30:21 +0100 Subject: [PATCH 07/28] Drop country name --- R/single_site.R | 1 + 1 file changed, 1 insertion(+) diff --git a/R/single_site.R b/R/single_site.R index 57ada64..38df16e 100644 --- a/R/single_site.R +++ b/R/single_site.R @@ -14,6 +14,7 @@ single_site <- function(site_file, index){ site <- list() for(level in names(site_file)){ mc <- intersect(colnames(index_site), colnames(site_file[[level]])) + mc <- setdiff(mc, "country") # Don't match on country name, match on ISO if they are present if(length(mc) == 0){ site[[level]] <- site_file[[level]] } else { From 1e806785933fa7bde0f567f6dddb69522d4867de Mon Sep 17 00:00:00 2001 From: Peter Winskill Date: Fri, 12 May 2023 13:08:08 +0100 Subject: [PATCH 08/28] Country name mismatch on single site --- R/single_site.R | 3 ++- 1 file changed, 2 insertions(+), 1 deletion(-) diff --git a/R/single_site.R b/R/single_site.R index 38df16e..236a97e 100644 --- a/R/single_site.R +++ b/R/single_site.R @@ -10,11 +10,12 @@ single_site <- function(site_file, index){ stop("Mis-specified site index") } index_site <- site_file$sites[index, ] + # Drop the country name as it has inconsistent spelling + index_site <- index_site[ , !names(index_site) == "country"] site <- list() for(level in names(site_file)){ mc <- intersect(colnames(index_site), colnames(site_file[[level]])) - mc <- setdiff(mc, "country") # Don't match on country name, match on ISO if they are present if(length(mc) == 0){ site[[level]] <- site_file[[level]] } else { From c2bc4e73cfa1cca4e10d19cf0c3ee61b47685477 Mon Sep 17 00:00:00 2001 From: Peter Winskill Date: Fri, 12 May 2023 13:11:50 +0100 Subject: [PATCH 09/28] bump version --- DESCRIPTION | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/DESCRIPTION b/DESCRIPTION index 0b98a48..d25c1cf 100644 --- a/DESCRIPTION +++ b/DESCRIPTION @@ -1,7 +1,7 @@ Package: site Type: Package Title: Site specific malariasimulation modelling -Version: 0.2.4 +Version: 0.2.5 Authors@R: c( person("Pete", "Winskill", email = "p.winskill@imperial.ac.uk", role = c("aut", "cre")) ) From 6dc77606b098cfec9df4a53e7743db016c282137 Mon Sep 17 00:00:00 2001 From: Peter Winskill Date: Tue, 6 Feb 2024 10:07:05 +0000 Subject: [PATCH 10/28] Sub set the site file --- R/single_site.R | 72 ++++++++++++++++++++++++++++++++++--------------- 1 file changed, 51 insertions(+), 21 deletions(-) diff --git a/R/single_site.R b/R/single_site.R index 236a97e..fb1bfcc 100644 --- a/R/single_site.R +++ b/R/single_site.R @@ -1,26 +1,56 @@ -#' Extract a single site-input from a country site file +#' Extract a subset from a country site file #' -#' @param site_file Country site file -#' @param index Index row from site_file$sites +#' @param site Country site file +#' @param site_filter Data.frame to filter site file elements by. Filtering will +#' be conducted on any matched columns for each element. #' -#' @return Single site +#' @return Filtered site file #' @export -single_site <- function(site_file, index){ - if(index < 1 | index > nrow(site_file$sites)){ - stop("Mis-specified site index") - } - index_site <- site_file$sites[index, ] - # Drop the country name as it has inconsistent spelling - index_site <- index_site[ , !names(index_site) == "country"] +subset_site <- function(site, site_filter){ - site <- list() - for(level in names(site_file)){ - mc <- intersect(colnames(index_site), colnames(site_file[[level]])) - if(length(mc) == 0){ - site[[level]] <- site_file[[level]] - } else { - site[[level]] <- dplyr::left_join(index_site, site_file[[level]], by = mc) - } - } - return(site) + sub_site <- list() + sub_site$country <- site$country + sub_site$version <- site$version + sub_site$admin_level <- site$admin_level + sub_site$sites <- site_filter[ , sub_site$admin_level] + sub_site$shape <- lapply( + site$shape, + match, + y = site_filter + ) + names(sub_site$shape) <- names(site$shape) + sub_site$cases_deaths <- match(site$cases_deaths, site_filter) + sub_site$prevalence <- match(site$prevalence, site_filter) + sub_site$interventions <- match(site$interventions, sub_site$site) + sub_site$population <- list( + population_total = match(site$population$population_total, sub_site$site), + population_by_age = match(site$population$population_by_age, sub_site$site) + ) + # TODO: demography + sub_site$vectors <- list( + vector_species = match(site$vectors$vector_species, sub_site$site), + pyrethroid_resistance = match(site$vectors$pyrethroid_resistance, sub_site$site) + ) + sub_site$seasonality <- list( + seasonality_parameters = match(site$seasonality$seasonality_parameters, sub_site$site), + monthly_rainfall = match(site$seasonality$monthly_rainfall, sub_site$site), + fourier_prediction = match(site$seasonality$fourier_prediction, sub_site$site) + ) + sub_site$blood_disorders <- match(site$blood_disorders, sub_site$site) + sub_site$accessibility <- match(site$accessibility, sub_site$site) + sub_site$eir <- match(site$eir, site_filter) + return(sub_site) +} + +#' Matched join +#' +#' @param x Site file element +#' @param y Data.frame to match for +#' +#' @return Site file element filtered by y +match <- function(x, y){ + by_names = names(y)[names(y) %in% names(x)] + y <- y[, by_names] + y |> + dplyr::left_join(x, by = by_names) } From 78844a940522043060bf6753567256d68a5533a9 Mon Sep 17 00:00:00 2001 From: Peter Winskill Date: Tue, 6 Feb 2024 10:30:39 +0000 Subject: [PATCH 11/28] Adding R21 and LSM options to interventions --- R/interventions.R | 107 +++++++++++++++++++++++++++++++++++----------- 1 file changed, 83 insertions(+), 24 deletions(-) diff --git a/R/interventions.R b/R/interventions.R index 6deb1a2..9023134 100644 --- a/R/interventions.R +++ b/R/interventions.R @@ -8,6 +8,7 @@ #' @return modified parameter list add_interventions <- function(p, interventions, species){ + pf <- species == "pf" # Drug types p <- add_drugs(p) # Treatment @@ -27,22 +28,51 @@ add_interventions <- function(p, interventions, species){ interventions = interventions) } # SMC - if(sum(interventions$smc_cov, na.rm = TRUE) > 0 & - species == "pf"){ - p <- add_smc(p = p, - interventions = interventions) + if(sum(interventions$smc_cov, na.rm = TRUE) > 0 & pf){ + p <- add_smc( + p = p, + interventions = interventions + ) } # RTSS - if(sum(interventions$rtss_cov, na.rm = TRUE) > 0 & - species == "pf"){ - p <- add_rtss(p = p, - interventions = interventions) + if(sum(interventions$rtss_cov, na.rm = TRUE) > 0 & pf){ + p <- add_rtss( + p = p, + interventions = interventions + ) + } + # R21 + if(sum(interventions$r21_cov, na.rm = TRUE) > 0 & pf){ + p <- add_r21( + p = p, + interventions = interventions + ) } # PMC - if(sum(interventions$pmc_cov, na.rm = TRUE) > 0 & - species == "pf"){ - p <- add_pmc(p = p, - interventions = interventions) + if(sum(interventions$pmc_cov, na.rm = TRUE) > 0 & pf){ + p <- add_pmc( + p = p, + interventions = interventions + ) + } + # Interventions that modify the carrying capacity + # The combined carrying capacity scaling must be estimated for all + # interventions that modify it, before updating. Currently, only LSM is + # implemented here. This could included An. stephensi in the future. + if(sum(interventions$lsm_cov, na.rm = TRUE) > 0){ + lsm_impact <- rep(1 - interventions$lsm_cov, each = length(p$species)) + carrying_capacity_scaler <- matrix( + data = lsm_impact, + ncol = length(p$species), + byrow = TRUE + ) + month <- 365 / 12 + timesteps <- 1 + (interventions$year - p$baseline_year) * 365 + + p <- malariasimulation::set_carrying_capacity( + carrying_capacity = carrying_capacity_scaler, + timesteps = timesteps + ) } return(p) @@ -88,15 +118,19 @@ add_treatment <- function(p, interventions){ timesteps <- 1 + (interventions$year - p$baseline_year) * 365 # Non ACT (SP) - p <- malariasimulation::set_clinical_treatment(parameters = p, - drug = 4, - timesteps = timesteps, - coverages = interventions$tx_cov * (1 - interventions$prop_act)) + p <- malariasimulation::set_clinical_treatment( + parameters = p, + drug = 4, + timesteps = timesteps, + coverages = interventions$tx_cov * (1 - interventions$prop_act) + ) # ACT (AL) - p <- malariasimulation::set_clinical_treatment(parameters = p, - drug = 5, - timesteps = timesteps, - coverages = interventions$tx_cov * interventions$prop_act) + p <- malariasimulation::set_clinical_treatment( + parameters = p, + drug = 5, + timesteps = timesteps, + coverages = interventions$tx_cov * interventions$prop_act + ) return(p) @@ -214,7 +248,6 @@ add_smc <- function(p, interventions){ } peak <- malariasimulation::peak_season_offset(p) - # Note: min age and max age are not currently time-varying rounds <- interventions$smc_n_rounds year_start_times <- 1 + (interventions$year - p$baseline_year) * 365 peak_season_times <- peak + year_start_times @@ -257,15 +290,41 @@ add_rtss <- function(p, interventions){ month <- 365 / 12 timesteps <- 1 + (interventions$year - p$baseline_year) * 365 - p <- malariasimulation::set_rtss_epi( + p <- malariasimulation::set_pev_epi( parameters = p, + profile = rtss_profile, timesteps = timesteps, coverages = interventions$rtss_cov, age = round(6 * month), min_wait = 0, - boosters = round(18 * month), + booster_timestep = 12 * month, # The booster is administered 12 months following the third dose. + booster_coverage = 0.8, + booster_profile = list(rtss_booster_profile) # We will model implementation of the RTSS booster. + ) + + return(p) +} + +#' Add RTS,S +#' +#' @inheritParams add_interventions +#' +#' @return modified parameter list +add_r21 <- function(p, interventions){ + month <- 365 / 12 + timesteps <- 1 + (interventions$year - p$baseline_year) * 365 + + p <- malariasimulation::set_pev_epi( + parameters = p, + profile = r21_profile, + timesteps = timesteps, + coverages = interventions$r21_cov, + # TODO: Check R21 timings/ages + age = round(6 * month), + min_wait = 0, + booster_timestep = 12 * month, # The booster is administered 12 months following the third dose. booster_coverage = 0.8, - seasonal_boosters = FALSE + booster_profile = list(r21_booster_profile) # We will model implementation of the RTSS booster. ) return(p) From eb66c57011ad365d48ae06c8eac9b9f54abe8586 Mon Sep 17 00:00:00 2001 From: Peter Winskill Date: Tue, 6 Feb 2024 10:33:31 +0000 Subject: [PATCH 12/28] Tidy drug specification --- R/interventions.R | 17 ++++++++++------- 1 file changed, 10 insertions(+), 7 deletions(-) diff --git a/R/interventions.R b/R/interventions.R index 9023134..f27494d 100644 --- a/R/interventions.R +++ b/R/interventions.R @@ -2,8 +2,8 @@ #' #' @param p parameter list #' @param interventions site intervention inputs -#' @param species Can be falciparum: "pf" or vivax: "pv", for vivax SMC, RTSS -#' and PMC are not implemented +#' @param species Can be falciparum: "pf" or vivax: "pv", for vivax SMC, RTSS, +#' R21 and PMC are not implemented #' #' @return modified parameter list add_interventions <- function(p, interventions, species){ @@ -98,11 +98,14 @@ add_drugs <- function(p){ p <- malariasimulation::set_drugs( parameters = p, - list(tetst = SP_params, - malariasimulation::AL_params, - malariasimulation::SP_AQ_params, - SP_full_efficacy, - AL_full_efficacy)) + list( + SP_params, + malariasimulation::AL_params, + malariasimulation::SP_AQ_params, + SP_full_efficacy, + AL_full_efficacy + ) + ) return(p) From 7c24b7b843490eb95b38c0dbd220268c71b858f9 Mon Sep 17 00:00:00 2001 From: Peter Winskill Date: Tue, 6 Feb 2024 10:37:10 +0000 Subject: [PATCH 13/28] Add new interventions to burnin adjustment --- R/burnin.R | 4 +++- R/interventions.R | 2 -- R/site_parameters.R | 1 - R/vectors.R | 5 +++-- 4 files changed, 6 insertions(+), 6 deletions(-) diff --git a/R/burnin.R b/R/burnin.R index 8585cc8..66d3376 100644 --- a/R/burnin.R +++ b/R/burnin.R @@ -18,7 +18,9 @@ burnin_interventions <- function(interventions, burnin){ irs_cov = 0, smc_cov = 0, rtss_cov = 0, - pmc_cov = 0 + r21_cov = 0, + pmc_cov = 0, + lsm_cov = 0 ) ) |> tidyr::fill(dplyr::everything(), .direction = "up") diff --git a/R/interventions.R b/R/interventions.R index f27494d..5e8e306 100644 --- a/R/interventions.R +++ b/R/interventions.R @@ -106,8 +106,6 @@ add_drugs <- function(p){ AL_full_efficacy ) ) - - return(p) } diff --git a/R/site_parameters.R b/R/site_parameters.R index faf294d..ae23639 100644 --- a/R/site_parameters.R +++ b/R/site_parameters.R @@ -18,7 +18,6 @@ site_parameters <- function(interventions, demography, vectors, seasonality, eir = NULL, overrides = list(), burnin = 0){ p <- malariasimulation::get_parameters(overrides = overrides) - p$individual_mosquitoes <- FALSE p$burnin <- 0 if(burnin > 0){ diff --git a/R/vectors.R b/R/vectors.R index 8026862..f94b322 100644 --- a/R/vectors.R +++ b/R/vectors.R @@ -6,7 +6,7 @@ #' @return modified parameter list add_vectors <- function(p, vectors){ bionomics <- vectors[ , c("species", "blood_meal_rates", "foraging_time", - "Q0", "phi_bednets", "phi_indoors", "mum")] + "Q0", "phi_bednets", "phi_indoors", "mum")] species <- list() for(s in 1:nrow(bionomics)){ @@ -16,7 +16,8 @@ add_vectors <- function(p, vectors){ p <- malariasimulation::set_species( parameters = p, species = species, - proportions = vectors$prop) + proportions = vectors$prop + ) return(p) } From 5fd9979f712ee030d53b9ff6326767ad80f778aa Mon Sep 17 00:00:00 2001 From: Peter Winskill Date: Tue, 6 Feb 2024 11:08:56 +0000 Subject: [PATCH 14/28] Demography uses adjusted mortality rates --- R/demography.R | 5 +---- 1 file changed, 1 insertion(+), 4 deletions(-) diff --git a/R/demography.R b/R/demography.R index cc5a577..c4a310d 100644 --- a/R/demography.R +++ b/R/demography.R @@ -8,11 +8,8 @@ add_demography <- function(p, demography){ # Age group upper ages <- round(unique(demography$age_upper) * 365) - # Single demography currently timesteps <- 365 * (unique(demography$year) - p$baseline_year) - # Take demography is first year as static demography - deathrates <- demography$mortality_rate / 365 - # Create matrix of death rates + deathrates <- demography$adjusted_mortality_rates / 365 deathrates_matrix <- matrix(deathrates, nrow = length(timesteps), byrow = TRUE) # Add parameters p <- malariasimulation::set_demography( From c3bbea19b68053deb43f44e65518053b9ac4dcfd Mon Sep 17 00:00:00 2001 From: Peter Winskill Date: Mon, 12 Feb 2024 13:53:15 +0000 Subject: [PATCH 15/28] Overhaul for site files v2.0 --- .Rbuildignore | 1 + DESCRIPTION | 2 +- NAMESPACE | 2 +- R/data.R | 18 +++++--- R/interventions.R | 32 ++++++++++++++- R/single_site.R | 9 ++-- data-raw/create_example_site.R | 11 +++++ data/example_site.rda | Bin 30161 -> 467325 bytes man/add_interventions.Rd | 4 +- man/add_r21.Rd | 19 +++++++++ man/example_site.Rd | 18 +++++--- man/match.Rd | 19 +++++++++ man/single_site.Rd | 19 --------- man/subset_site.Rd | 20 +++++++++ tests/testthat/test-add_time.R | 2 +- tests/testthat/test-burnin.R | 6 +-- tests/testthat/test-demography.R | 4 +- tests/testthat/test-irs.R | 34 +++++++-------- tests/testthat/test-itns.R | 9 ++-- tests/testthat/test-pmc.R | 4 +- tests/testthat/test-rtss.R | 19 --------- tests/testthat/test-seasonality.R | 4 +- tests/testthat/test-site_parameters.R | 36 ++++++++-------- tests/testthat/test-smc.R | 7 ++-- tests/testthat/test-treatment.R | 13 +++--- tests/testthat/test-vaccine.R | 57 ++++++++++++++++++++++++++ tests/testthat/test-vectors.R | 4 +- 27 files changed, 256 insertions(+), 117 deletions(-) create mode 100644 data-raw/create_example_site.R create mode 100644 man/add_r21.Rd create mode 100644 man/match.Rd delete mode 100644 man/single_site.Rd create mode 100644 man/subset_site.Rd delete mode 100644 tests/testthat/test-rtss.R create mode 100644 tests/testthat/test-vaccine.R diff --git a/.Rbuildignore b/.Rbuildignore index 43df59c..931b37f 100644 --- a/.Rbuildignore +++ b/.Rbuildignore @@ -7,3 +7,4 @@ ^docs$ ^pkgdown$ add_data_temp.R +data-raw diff --git a/DESCRIPTION b/DESCRIPTION index d25c1cf..2842871 100644 --- a/DESCRIPTION +++ b/DESCRIPTION @@ -1,7 +1,7 @@ Package: site Type: Package Title: Site specific malariasimulation modelling -Version: 0.2.5 +Version: 1.0.0 Authors@R: c( person("Pete", "Winskill", email = "p.winskill@imperial.ac.uk", role = c("aut", "cre")) ) diff --git a/NAMESPACE b/NAMESPACE index 485614d..d1157fe 100644 --- a/NAMESPACE +++ b/NAMESPACE @@ -1,4 +1,4 @@ # Generated by roxygen2: do not edit by hand -export(single_site) export(site_parameters) +export(subset_site) diff --git a/R/data.R b/R/data.R index 55fbd33..089e31b 100644 --- a/R/data.R +++ b/R/data.R @@ -5,14 +5,20 @@ #' #' @format A list with 10 variables: #' \describe{ -#' \item{country}{The iso3c country code} -#' \item{level}{The level of subnational disaggregation} +#' \item{country}{The country name} +#' \item{version}{Site file version} +#' \item{admin_level}{The levels of spatial disaggregation} #' \item{sites}{Unique sites} -#' \item{epi}{Epidemiological site data} +#' \item{shape}{Sptial boundaries (set to NA in testing shapefile)} +#' \item{cases_deaths}{Epidemiological site data} +#' \item{prevalence}{Prevalence data} #' \item{interventions}{Intervention coverage and specification} -#' \item{population}{Population and population at risk projections} +#' \item{population}{Population, population at risk mand age-disaggregated population projections} #' \item{demography}{Demographic projections} -#' \item{vectors}{Vector proportions} -#' \item{seasonality}{Seasonal profile parameters} +#' \item{vectors}{Vector specieis and pyrethroid resistance} +#' \item{seasonality}{Seasonal profile parameters, monthly rainfall and fourier predictions} +#' \item{blood_disorders}{Blood disorder data} +#' \item{accessibility}{Accessibility data} +#' \item{eir}{Calibrated eir} #' } "example_site" diff --git a/R/interventions.R b/R/interventions.R index 5e8e306..8e654bd 100644 --- a/R/interventions.R +++ b/R/interventions.R @@ -34,6 +34,15 @@ add_interventions <- function(p, interventions, species){ interventions = interventions ) } + + if( + sum(interventions$rtss_cov, na.rm = TRUE) > 0 & + sum(interventions$r21_cov, na.rm = TRUE) > 0 + ) { + warning("Cannot currently model two vaccine types, + defaulting to R21 coverage inputs") + interventions$rtss_cov <- 0 + } # RTSS if(sum(interventions$rtss_cov, na.rm = TRUE) > 0 & pf){ p <- add_rtss( @@ -293,14 +302,14 @@ add_rtss <- function(p, interventions){ p <- malariasimulation::set_pev_epi( parameters = p, - profile = rtss_profile, + profile = malariasimulation::rtss_profile, timesteps = timesteps, coverages = interventions$rtss_cov, age = round(6 * month), min_wait = 0, booster_timestep = 12 * month, # The booster is administered 12 months following the third dose. booster_coverage = 0.8, - booster_profile = list(rtss_booster_profile) # We will model implementation of the RTSS booster. + booster_profile = list(malariasimulation::rtss_booster_profile) # We will model implementation of the RTSS booster. ) return(p) @@ -315,6 +324,25 @@ add_r21 <- function(p, interventions){ month <- 365 / 12 timesteps <- 1 + (interventions$year - p$baseline_year) * 365 + r21_profile <- malariasimulation::create_pev_profile( + vmax = 0.87, + alpha = 0.91, + beta = 471, + cs = c(9.3199677, 0.8387902), + rho = c(0.8071676, 0.6010363), + ds = c(3.7996007, 0.1618982), + dl =c(6.2820200, 0.4549185) + ) + r21_booster_profile <- malariasimulation::create_pev_profile( + vmax = 0.87, + alpha = 0.91, + beta = 471, + cs = c(9.2372858, 0.7188541), + rho = c(0.07140337, 0.54175154), + ds = c(3.7996007, 0.1618982), + dl =c(6.2820200, 0.4549185) + ) + p <- malariasimulation::set_pev_epi( parameters = p, profile = r21_profile, diff --git a/R/single_site.R b/R/single_site.R index fb1bfcc..a468ee7 100644 --- a/R/single_site.R +++ b/R/single_site.R @@ -26,7 +26,7 @@ subset_site <- function(site, site_filter){ population_total = match(site$population$population_total, sub_site$site), population_by_age = match(site$population$population_by_age, sub_site$site) ) - # TODO: demography + sub_site$demography <- match(site$demography, sub_site$site) sub_site$vectors <- list( vector_species = match(site$vectors$vector_species, sub_site$site), pyrethroid_resistance = match(site$vectors$pyrethroid_resistance, sub_site$site) @@ -49,8 +49,11 @@ subset_site <- function(site, site_filter){ #' #' @return Site file element filtered by y match <- function(x, y){ - by_names = names(y)[names(y) %in% names(x)] - y <- y[, by_names] + by_names <- names(y)[names(y) %in% names(x)] + if(length(by_names) == 0){ + return(x) + } + y <- y[, by_names, drop = FALSE] y |> dplyr::left_join(x, by = by_names) } diff --git a/data-raw/create_example_site.R b/data-raw/create_example_site.R new file mode 100644 index 0000000..94fb2c8 --- /dev/null +++ b/data-raw/create_example_site.R @@ -0,0 +1,11 @@ +example_site <- readRDS("c:/users/pwinskil/desktop/site.rds") +example_site$eir$eir <- 5 + +example_site$shape <- lapply(example_site$shape, function(x){ + data.frame() +}) +example_site$population$population_by_age <- data.frame() + +format(object.size(example_site), "Mb") + 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