diff --git a/aio_pika/patterns/rpc.py b/aio_pika/patterns/rpc.py
index bbec383e..80a05c53 100644
--- a/aio_pika/patterns/rpc.py
+++ b/aio_pika/patterns/rpc.py
@@ -84,11 +84,17 @@ def __init__(self, channel: Channel):
         self.queues = {}
         self.consumer_tags = {}
         self.dlx_exchange = None
+        self.rpc_exchange = None
 
     def __remove_future(self, future: asyncio.Future):
         log.debug("Remove done future %r", future)
         self.futures.pop(id(future), None)
 
+    def _routing_key(self, method_name):
+        return '{}::{}'.format(self.rpc_exchange.name, method_name) \
+            if self.rpc_exchange \
+            else method_name
+
     def create_future(self) -> asyncio.Future:
         future = self.loop.create_future()
         log.debug("Create future for RPC call")
@@ -126,10 +132,21 @@ async def close(self):
         self.result_queue = None
 
     @shield
-    async def initialize(self, auto_delete=True, durable=False, **kwargs):
+    async def initialize(self,
+                         auto_delete=True,
+                         durable=False,
+                         exchange='',
+                         **kwargs):
         if self.result_queue is not None:
             return
 
+        if exchange:
+            self.rpc_exchange = await self.channel.declare_exchange(
+                exchange,
+                type=ExchangeType.DIRECT,
+                auto_delete=True,
+                durable=durable)
+
         self.result_queue = await self.channel.declare_queue(
             None, auto_delete=auto_delete, durable=durable, **kwargs
         )
@@ -222,13 +239,15 @@ async def on_result_message(self, message: IncomingMessage):
     async def on_call_message(
         self, method_name: str, message: IncomingMessage
     ):
-        if method_name not in self.routes:
+        routing_key = self._routing_key(method_name)
+
+        if routing_key not in self.routes:
             log.warning("Method %r not registered in %r", method_name, self)
             return
 
         try:
             payload = self.deserialize(message.body)
-            func = self.routes[method_name]
+            func = self.routes[routing_key]
 
             result = await self.execute(func, payload)
             result = self.serialize(result)
@@ -341,12 +360,19 @@ async def call(
         if expiration is not None:
             message.expiration = expiration
 
-        log.debug("Publishing calls for %s(%r)", method_name, kwargs)
-        await self.channel.default_exchange.publish(
-            message, routing_key=method_name, mandatory=True,
-        )
+        routing_key = self._routing_key(method_name)
+
+        log.debug("Publishing calls for %s(%r)", routing_key, kwargs)
+        if self.rpc_exchange:
+            await self.rpc_exchange.publish(
+                message, routing_key=routing_key, mandatory=True,
+            )
+        else:
+            await self.channel.default_exchange.publish(
+                message, routing_key=routing_key, mandatory=True,
+            )
 
-        log.debug("Waiting RPC result for %s(%r)", method_name, kwargs)
+        log.debug("Waiting RPC result for %s(%r)", routing_key, kwargs)
         return await future
 
     async def register(self, method_name, func: CallbackType, **kwargs):
@@ -366,21 +392,29 @@ async def register(self, method_name, func: CallbackType, **kwargs):
 
         kwargs["arguments"] = arguments
 
-        queue = await self.channel.declare_queue(method_name, **kwargs)
+        routing_key = self._routing_key(method_name)
+
+        queue = await self.channel.declare_queue(routing_key, **kwargs)
+
+        if self.rpc_exchange:
+            await queue.bind(
+                self.rpc_exchange,
+                routing_key
+            )
 
         if func in self.consumer_tags:
             raise RuntimeError("Function already registered")
 
-        if method_name in self.routes:
+        if routing_key in self.routes:
             raise RuntimeError(
-                "Method name already used for %r" % self.routes[method_name],
+                "Method name already used for %r" % self.routes[routing_key],
             )
 
         self.consumer_tags[func] = await queue.consume(
             partial(self.on_call_message, method_name),
         )
 
-        self.routes[method_name] = awaitable(func)
+        self.routes[routing_key] = awaitable(func)
         self.queues[func] = queue
 
     async def unregister(self, func):
diff --git a/tests/test_rpc.py b/tests/test_rpc.py
index 8582489e..43accafe 100644
--- a/tests/test_rpc.py
+++ b/tests/test_rpc.py
@@ -19,6 +19,13 @@ def rpc_func(*, foo, bar):
     return {"foo": "bar"}
 
 
+def rpc_func2(*, foo, bar):
+    assert not foo
+    assert not bar
+
+    return {"foo": "bar2"}
+
+
 class TestCase:
     async def test_simple(self, channel: aio_pika.Channel):
         rpc = await RPC.create(channel, auto_delete=True)
@@ -172,3 +179,35 @@ async def test_register_twice(self, channel: aio_pika.Channel):
         await rpc.unregister(rpc_func)
 
         await rpc.close()
+
+    async def test_custom_exchange(self, channel: aio_pika.Channel):
+        rpc_ex1 = await RPC.create(channel, auto_delete=True, exchange='ex1')
+        rpc_ex2 = await RPC.create(channel, auto_delete=True, exchange='ex2')
+        rpc_default = await RPC.create(channel, auto_delete=True)
+
+        await rpc_ex1.register("test.rpc", rpc_func, auto_delete=True)
+        result = await rpc_ex1.proxy.test.rpc(foo=None, bar=None)
+        assert result == {"foo": "bar"}
+
+        with pytest.raises(DeliveryError):
+            await rpc_ex2.proxy.test.rpc(foo=None, bar=None)
+
+        await rpc_ex2.register("test.rpc", rpc_func2, auto_delete=True)
+        result = await rpc_ex2.proxy.test.rpc(foo=None, bar=None)
+        assert result == {"foo": "bar2"}
+
+        with pytest.raises(DeliveryError):
+            await rpc_default.proxy.test.rpc(foo=None, bar=None)
+
+        await rpc_default.register("test.rpc", rpc_func, auto_delete=True)
+        result = await rpc_default.proxy.test.rpc(foo=None, bar=None)
+        assert result == {"foo": "bar"}
+
+        await rpc_ex1.unregister(rpc_func)
+        await rpc_ex1.close()
+
+        await rpc_ex2.unregister(rpc_func2)
+        await rpc_ex2.close()
+
+        await rpc_default.unregister(rpc_func)
+        await rpc_default.close()