diff --git a/.github/workflows/release.yml b/.github/workflows/release.yml
new file mode 100644
index 000000000..0cf02ae2d
--- /dev/null
+++ b/.github/workflows/release.yml
@@ -0,0 +1,51 @@
+# Upload a Python Package using Twine when a release is created
+
+name: Build
+on:  # yamllint disable-line rule:truthy
+  release:
+    types: [published]
+  push:
+    branches:
+      - main
+  pull_request:
+    branches:
+      - main
+
+permissions:
+  contents: read
+
+jobs:
+  package:
+    runs-on: ubuntu-latest
+    steps:
+      - uses: actions/checkout@v4
+      - uses: actions/setup-python@v5
+        with:
+          python-version: '3.12'
+      - name: Install dependencies
+        run: |
+          python -m pip install --upgrade pip
+          pip install build twine
+      - run: python -m build --sdist --wheel
+      - run: twine check --strict dist/*
+      - uses: actions/upload-artifact@v4
+        with:
+          name: dist
+          path: dist
+
+  pypi-upload:
+    needs: package
+    runs-on: ubuntu-latest
+    if: github.event_name == 'release'
+    permissions:
+      id-token: write  # for trusted publishing
+    environment:
+      name: pypi
+      url: https://pypi.org/p/mne
+    steps:
+      - uses: actions/download-artifact@v4
+        with:
+          name: dist
+          path: dist
+      - uses: pypa/gh-action-pypi-publish@release/v1
+        if: github.event_name == 'release'