diff --git a/cmake/onnxruntime_common.cmake b/cmake/onnxruntime_common.cmake
index 69d8f5fa138c7..896379d743441 100644
--- a/cmake/onnxruntime_common.cmake
+++ b/cmake/onnxruntime_common.cmake
@@ -71,6 +71,12 @@ if(onnxruntime_target_platform STREQUAL "ARM64EC")
     endif()
 endif()
 
+if(onnxruntime_target_platform STREQUAL "ARM64")
+    if (MSVC)
+        add_compile_options("/bigobj")
+    endif()
+endif()
+
 file(GLOB onnxruntime_common_src CONFIGURE_DEPENDS
     ${onnxruntime_common_src_patterns}
     )
diff --git a/cmake/onnxruntime_nodejs.cmake b/cmake/onnxruntime_nodejs.cmake
index 555baac6f1a51..f11928c11cf14 100644
--- a/cmake/onnxruntime_nodejs.cmake
+++ b/cmake/onnxruntime_nodejs.cmake
@@ -73,6 +73,9 @@ endif()
 if (onnxruntime_USE_COREML)
     set(NODEJS_BINDING_USE_COREML "--use_coreml")
 endif()
+if (onnxruntime_USE_QNN)
+    set(NODEJS_BINDING_USE_QNN "--use_qnn")
+endif()
 
 if(NOT onnxruntime_ENABLE_STATIC_ANALYSIS)
 # add custom target
@@ -90,7 +93,7 @@ add_custom_target(nodejs_binding_wrapper ALL
     COMMAND ${NPM_CLI} ci
     COMMAND ${NPM_CLI} run build -- --onnxruntime-build-dir=${CMAKE_CURRENT_BINARY_DIR} --config=${CMAKE_BUILD_TYPE} --onnxruntime-generator=${CMAKE_GENERATOR}
         --arch=${NODEJS_BINDING_ARCH} ${NODEJS_BINDING_USE_CUDA} ${NODEJS_BINDING_USE_DML} ${NODEJS_BINDING_USE_TENSORRT}
-        ${NODEJS_BINDING_USE_COREML}
+        ${NODEJS_BINDING_USE_COREML} ${NODEJS_BINDING_USE_QNN}
     WORKING_DIRECTORY ${JS_NODE_ROOT}
     COMMENT "Using cmake-js to build OnnxRuntime Node.js binding")
 
diff --git a/js/common/lib/inference-session.ts b/js/common/lib/inference-session.ts
index 14db5c59d972a..353d93bbc34ae 100644
--- a/js/common/lib/inference-session.ts
+++ b/js/common/lib/inference-session.ts
@@ -201,6 +201,7 @@ export declare namespace InferenceSession {
     webgl: WebGLExecutionProviderOption;
     webgpu: WebGpuExecutionProviderOption;
     webnn: WebNNExecutionProviderOption;
+    qnn: QnnExecutionProviderOption;
     xnnpack: XnnpackExecutionProviderOption;
   }
 
@@ -247,6 +248,10 @@ export declare namespace InferenceSession {
     numThreads?: number;
     powerPreference?: 'default'|'low-power'|'high-performance';
   }
+  export interface QnnExecutionProviderOption extends ExecutionProviderOption {
+    readonly name: 'qnn';
+    // TODO add flags
+  }
   export interface CoreMLExecutionProviderOption extends ExecutionProviderOption {
     readonly name: 'coreml';
     /**
diff --git a/js/node/CMakeLists.txt b/js/node/CMakeLists.txt
index 8157df288eeb9..5c32f62f3a802 100644
--- a/js/node/CMakeLists.txt
+++ b/js/node/CMakeLists.txt
@@ -37,6 +37,7 @@ option(USE_DML "Build with DirectML support" OFF)
 option(USE_CUDA "Build with CUDA support" OFF)
 option(USE_TENSORRT "Build with TensorRT support" OFF)
 option(USE_COREML "Build with CoreML support" OFF)
+option(USE_QNN "Build with QNN support" OFF)
 
 if(USE_DML)
   add_compile_definitions(USE_DML=1)
@@ -50,6 +51,9 @@ endif()
 if(USE_COREML)
   add_compile_definitions(USE_COREML=1)
 endif()
+if(USE_QNN)
+  add_compile_definitions(USE_QNN=1)
+endif()
 
 # source files
 file(GLOB ORT_NODEJS_BINDING_SOURCE_FILES ${CMAKE_SOURCE_DIR}/src/*.cc)
diff --git a/js/node/script/build.ts b/js/node/script/build.ts
index cc59507179085..3f0f804ed368e 100644
--- a/js/node/script/build.ts
+++ b/js/node/script/build.ts
@@ -35,6 +35,8 @@ const USE_CUDA = !!buildArgs.use_cuda;
 const USE_TENSORRT = !!buildArgs.use_tensorrt;
 // --use_coreml
 const USE_COREML = !!buildArgs.use_coreml;
+// --use_qnn
+const USE_QNN = !!buildArgs.use_qnn;
 
 // build path
 const ROOT_FOLDER = path.join(__dirname, '..');
@@ -72,6 +74,9 @@ if (USE_TENSORRT) {
 if (USE_COREML) {
   args.push('--CDUSE_COREML=ON');
 }
+if (USE_QNN) {
+  args.push('--CDUSE_QNN=ON');
+}
 
 // set CMAKE_OSX_ARCHITECTURES for macOS build
 if (os.platform() === 'darwin') {
diff --git a/js/node/src/inference_session_wrap.cc b/js/node/src/inference_session_wrap.cc
index 1bbb6df1ce1c8..b85104cadc6ed 100644
--- a/js/node/src/inference_session_wrap.cc
+++ b/js/node/src/inference_session_wrap.cc
@@ -252,6 +252,9 @@ Napi::Value InferenceSessionWrap::ListSupportedBackends(const Napi::CallbackInfo
 #ifdef USE_COREML
   result.Set(result.Length(), createObject("coreml", true));
 #endif
+#ifdef USE_QNN
+  result.Set(result.Length(), createObject("qnn", true));
+#endif
 
   return scope.Escape(result);
 }
diff --git a/js/node/src/session_options_helper.cc b/js/node/src/session_options_helper.cc
index a0de832d87fe5..46e08010b7835 100644
--- a/js/node/src/session_options_helper.cc
+++ b/js/node/src/session_options_helper.cc
@@ -80,6 +80,13 @@ void ParseExecutionProviders(const Napi::Array epList, Ort::SessionOptions &sess
 #ifdef USE_COREML
     } else if (name == "coreml") {
       Ort::ThrowOnError(OrtSessionOptionsAppendExecutionProvider_CoreML(sessionOptions, coreMlFlags));
+#endif
+#ifdef USE_QNN
+    } else if (name == "qnn") {
+      std::unordered_map<std::string, std::string> qnn_options;
+      qnn_options["backend_path"] = "QnnHtp.dll";
+      qnn_options["enable_htp_fp16_precision"] = "1";
+      sessionOptions.AppendExecutionProvider("QNN", qnn_options);
 #endif
     } else {
       ORT_NAPI_THROW_ERROR(epList.Env(), "Invalid argument: sessionOptions.executionProviders[", i,