diff --git a/tools/ci_build/build.py b/tools/ci_build/build.py
index 6ae138f3fd92a..ad53419db5ba3 100644
--- a/tools/ci_build/build.py
+++ b/tools/ci_build/build.py
@@ -425,7 +425,7 @@ def convert_arg_line_to_args(self, arg_line):
         "--enable_address_sanitizer", action="store_true", help="Enable address sanitizer. Windows/Linux/MacOS only."
     )
     # The following feature requires installing some special Visual Studio components that do not get installed by default. Therefore the options is default OFF.
-    parser.add_argument("--enable_qspectre", action="store_true", help="Enable Qspectre. Windows only.")
+    parser.add_argument("--use_preset_compile_flags", action="store_true", help="Enable Qspectre. Windows only.")
     parser.add_argument(
         "--disable_memleak_checker",
         action="store_true",
@@ -1460,16 +1460,7 @@ def generate_build_tree(
     for config in configs:
         # Setup default values for cflags/cxxflags/ldflags.
         # The values set here are purely for security and compliance purposes. ONNX Runtime should work fine without these flags.
-        if (
-            "CFLAGS" not in os.environ
-            and "CXXFLAGS" not in os.environ
-            and (not args.use_cuda or "CUDAFLAGS" not in os.environ)
-            and not args.ios
-            and not args.android
-            and not args.build_wasm
-            and not args.use_rocm
-            and not (is_linux() and platform.machine() != "aarch64" and platform.machine() != "x86_64")
-        ):
+        if args.use_preset_compile_flags and not args.ios and not args.android and not args.build_wasm:
             if is_windows():
                 cflags = ["/guard:cf", "/DWIN32", "/D_WINDOWS"]
                 njobs = number_of_parallel_jobs(args)
@@ -1489,8 +1480,7 @@ def generate_build_tree(
                 # The "/profile" flag implies "/DEBUG:FULL /DEBUGTYPE:cv,fixup /OPT:REF /OPT:NOICF /INCREMENTAL:NO /FIXED:NO". We set it for satisfying a Microsoft internal compliance requirement. External users
                 # do not need to have it.
                 ldflags = ["/profile", "/DYNAMICBASE"]
-                if args.enable_qspectre:
-                    cflags += ["/Qspectre"]
+                cflags += ["/Qspectre"]
                 if config == "Release":
                     cflags += ["/O2", "/Ob2", "/DNDEBUG"]
                 elif config == "RelWithDebInfo":
diff --git a/tools/ci_build/github/azure-pipelines/linux-ci-pipeline.yml b/tools/ci_build/github/azure-pipelines/linux-ci-pipeline.yml
index cff7c96aa9253..93e4ada0fc406 100644
--- a/tools/ci_build/github/azure-pipelines/linux-ci-pipeline.yml
+++ b/tools/ci_build/github/azure-pipelines/linux-ci-pipeline.yml
@@ -93,7 +93,7 @@ stages:
                         --config Debug \
                         --skip_submodule_sync \
                         --build_shared_lib \
-                        --parallel \
+                        --parallel --use_preset_compile_flags \
                         --build_csharp \
                         --enable_onnx_tests --enable_address_sanitizer \
                         --update --build;
@@ -102,7 +102,7 @@ stages:
                         --config Debug \
                         --skip_submodule_sync \
                         --build_shared_lib \
-                        --parallel \
+                        --parallel --use_preset_compile_flags \
                         --build_csharp \
                         --enable_onnx_tests --enable_address_sanitizer \
                         --test;"
@@ -228,7 +228,7 @@ stages:
                         --config Release \
                         --skip_submodule_sync \
                         --build_shared_lib \
-                        --parallel \
+                        --parallel --use_preset_compile_flags \
                         --build_wheel \
                         --build_csharp \
                         --enable_onnx_tests \
diff --git a/tools/ci_build/github/azure-pipelines/linux-cpu-aten-pipeline.yml b/tools/ci_build/github/azure-pipelines/linux-cpu-aten-pipeline.yml
index 090ce97296687..e0c85fd86ead4 100644
--- a/tools/ci_build/github/azure-pipelines/linux-cpu-aten-pipeline.yml
+++ b/tools/ci_build/github/azure-pipelines/linux-cpu-aten-pipeline.yml
@@ -94,7 +94,7 @@ jobs:
                       --config Release \
                       --skip_submodule_sync \
                       --build_shared_lib \
-                      --parallel \
+                      --parallel --use_preset_compile_flags \
                       --build_wheel \
                       --skip_tests \
                       --cmake_extra_defines onnxruntime_ENABLE_ATEN=ON \
@@ -126,7 +126,7 @@ jobs:
                 --config Release \
                 --skip_submodule_sync \
                 --build_shared_lib \
-                --parallel \
+                --parallel --use_preset_compile_flags \
                 --build_wheel \
                 --test \
                 --cmake_extra_defines onnxruntime_ENABLE_ATEN=ON"
diff --git a/tools/ci_build/github/azure-pipelines/linux-cpu-eager-pipeline.yml b/tools/ci_build/github/azure-pipelines/linux-cpu-eager-pipeline.yml
index d3d13cc5344da..3e821b762757d 100644
--- a/tools/ci_build/github/azure-pipelines/linux-cpu-eager-pipeline.yml
+++ b/tools/ci_build/github/azure-pipelines/linux-cpu-eager-pipeline.yml
@@ -80,7 +80,7 @@ jobs:
               --config Release \
               --skip_submodule_sync \
               --build_shared_lib \
-              --parallel \
+              --parallel --use_preset_compile_flags \
               --enable_lazy_tensor --enable_training --build_wheel --skip_test \
       workingDirectory: $(Build.SourcesDirectory)
 
diff --git a/tools/ci_build/github/azure-pipelines/linux-cpu-minimal-build-ci-pipeline.yml b/tools/ci_build/github/azure-pipelines/linux-cpu-minimal-build-ci-pipeline.yml
index 1df36c2f2fb13..a9ef5a81226a3 100644
--- a/tools/ci_build/github/azure-pipelines/linux-cpu-minimal-build-ci-pipeline.yml
+++ b/tools/ci_build/github/azure-pipelines/linux-cpu-minimal-build-ci-pipeline.yml
@@ -141,7 +141,7 @@ jobs:
               --config Debug \
               --skip_submodule_sync \
               --build_shared_lib \
-              --parallel \
+              --parallel --use_preset_compile_flags \
               --skip_tests \
               --minimal_build \
               --disable_exceptions \
@@ -222,7 +222,7 @@ jobs:
               --build_dir /build/5 --cmake_generator Ninja \
               --config Debug \
               --skip_submodule_sync \
-              --build_shared_lib \
+              --build_shared_lib --use_preset_compile_flags \
               --parallel \
               --minimal_build extended
       workingDirectory: $(Build.SourcesDirectory)
@@ -246,7 +246,7 @@ jobs:
               --skip_submodule_sync \
               --build_shared_lib \
               --build_wheel \
-              --parallel \
+              --parallel --use_preset_compile_flags \
               --skip_tests \
               --disable_ml_ops \
               --disable_types sparsetensor float8 optional \
@@ -272,7 +272,7 @@ jobs:
               --config MinSizeRel \
               --skip_submodule_sync \
               --build_shared_lib \
-              --parallel \
+              --parallel --use_preset_compile_flags \
               --minimal_build \
               --disable_exceptions \
               --disable_ml_ops \
@@ -300,7 +300,7 @@ jobs:
               --cmake_generator Ninja \
               --config MinSizeRel \
               --skip_submodule_sync \
-              --build_shared_lib \
+              --build_shared_lib --use_preset_compile_flags \
               --parallel \
               --minimal_build extended \
               --disable_exceptions \
@@ -330,7 +330,7 @@ jobs:
               --cmake_generator Ninja \
               --config MinSizeRel \
               --skip_submodule_sync \
-              --parallel \
+              --parallel --use_preset_compile_flags \
               --android \
               --android_sdk_path /android_home \
               --android_ndk_path /ndk_home \
diff --git a/tools/ci_build/github/azure-pipelines/linux-gpu-ci-pipeline.yml b/tools/ci_build/github/azure-pipelines/linux-gpu-ci-pipeline.yml
index 1060a0138e0b7..3ba8ebb084eeb 100644
--- a/tools/ci_build/github/azure-pipelines/linux-gpu-ci-pipeline.yml
+++ b/tools/ci_build/github/azure-pipelines/linux-gpu-ci-pipeline.yml
@@ -131,7 +131,7 @@ jobs:
             --config Release --update --build \
             --skip_submodule_sync \
             --build_shared_lib \
-            --parallel \
+            --parallel --use_preset_compile_flags \
             --build_wheel \
             --enable_onnx_tests --use_cuda --cuda_version=${{parameters.CudaVersion}} --cuda_home=/usr/local/cuda-${{parameters.CudaVersion}} --cudnn_home=/usr/local/cuda-${{parameters.CudaVersion}} \
             --enable_cuda_profiling --enable_cuda_nhwc_ops \
@@ -215,7 +215,7 @@ jobs:
             cd /onnxruntime_src/java && /onnxruntime_src/java/gradlew cmakeCheck -DcmakeBuildDir=/build/Release -DUSE_CUDA=1; \
             cd /tmp; \
             /tmp/python3 /onnxruntime_src/tools/ci_build/build.py \
-              --build_dir /build --config Release --test --skip_submodule_sync --build_shared_lib --parallel --build_wheel --enable_onnx_tests \
+              --build_dir /build --config Release --test --skip_submodule_sync --build_shared_lib --parallel --use_preset_compile_flags --build_wheel --enable_onnx_tests \
               --use_cuda --cuda_version=${{parameters.CudaVersion}} --cuda_home=/usr/local/cuda --cudnn_home=/usr/local/cuda \
               --enable_pybind --build_java --ctest_path '' "
 
diff --git a/tools/ci_build/github/azure-pipelines/linux-gpu-tensorrt-ci-pipeline.yml b/tools/ci_build/github/azure-pipelines/linux-gpu-tensorrt-ci-pipeline.yml
index 4ca11a4d1565b..a49aba9c2baed 100644
--- a/tools/ci_build/github/azure-pipelines/linux-gpu-tensorrt-ci-pipeline.yml
+++ b/tools/ci_build/github/azure-pipelines/linux-gpu-tensorrt-ci-pipeline.yml
@@ -114,7 +114,7 @@ jobs:
                       --config Release \
                       --skip_submodule_sync \
                       --build_shared_lib \
-                      --parallel \
+                      --parallel --use_preset_compile_flags \
                       --build_wheel \
                       --enable_onnx_tests \
                       --use_cuda --cuda_home=/usr/local/cuda-${{ parameters.CudaVersion }} --cudnn_home=/usr/local/cuda-${{ parameters.CudaVersion }} \
diff --git a/tools/ci_build/github/azure-pipelines/linux-qnn-ci-pipeline.yml b/tools/ci_build/github/azure-pipelines/linux-qnn-ci-pipeline.yml
index 07910911ab67a..526f9d2dfc6ac 100644
--- a/tools/ci_build/github/azure-pipelines/linux-qnn-ci-pipeline.yml
+++ b/tools/ci_build/github/azure-pipelines/linux-qnn-ci-pipeline.yml
@@ -63,7 +63,7 @@ jobs:
           python3 tools/ci_build/build.py \
             --build_dir build \
             --config Release \
-            --parallel \
+            --parallel --use_preset_compile_flags \
             --use_qnn \
             --qnn_home $(QNN_SDK_ROOT) \
             --cmake_generator=Ninja \
@@ -73,7 +73,7 @@ jobs:
       - script: |
           python3 tools/ci_build/build.py \
             --build_dir build \
-            --config Release \
+            --config Release --use_preset_compile_flags \
             --test \
             --qnn_home $(QNN_SDK_ROOT) \
             --cmake_generator=Ninja \
diff --git a/tools/ci_build/github/azure-pipelines/mac-coreml-ci-pipeline.yml b/tools/ci_build/github/azure-pipelines/mac-coreml-ci-pipeline.yml
index f5472a49c5148..90b17a403714f 100644
--- a/tools/ci_build/github/azure-pipelines/mac-coreml-ci-pipeline.yml
+++ b/tools/ci_build/github/azure-pipelines/mac-coreml-ci-pipeline.yml
@@ -57,7 +57,7 @@ jobs:
           --build_dir build \
           --skip_submodule_sync \
           --cmake_generator=Ninja \
-          --parallel \
+          --parallel --use_preset_compile_flags \
           --build_shared_lib \
           --config Debug \
           --use_cache \
diff --git a/tools/ci_build/github/azure-pipelines/mac-ios-ci-pipeline.yml b/tools/ci_build/github/azure-pipelines/mac-ios-ci-pipeline.yml
index 33701fccf0c5f..9c69a1f70f33e 100644
--- a/tools/ci_build/github/azure-pipelines/mac-ios-ci-pipeline.yml
+++ b/tools/ci_build/github/azure-pipelines/mac-ios-ci-pipeline.yml
@@ -62,7 +62,7 @@ jobs:
                 --use_xcode \
                 --config RelWithDebInfo \
                 --build_apple_framework \
-                --parallel
+                --parallel --use_preset_compile_flags
             displayName: (CPU, CoreML, XNNPACK EPs) Build onnxruntime for iOS x86_64 and run tests using simulator
             env:
               CC: clang
diff --git a/tools/ci_build/github/azure-pipelines/mac-objc-static-analysis-ci-pipeline.yml b/tools/ci_build/github/azure-pipelines/mac-objc-static-analysis-ci-pipeline.yml
index 6893fb95cfec5..d4f12c4ba360f 100644
--- a/tools/ci_build/github/azure-pipelines/mac-objc-static-analysis-ci-pipeline.yml
+++ b/tools/ci_build/github/azure-pipelines/mac-objc-static-analysis-ci-pipeline.yml
@@ -26,7 +26,7 @@ jobs:
         --enable_training_apis \
         --cmake_extra_defines CMAKE_EXPORT_COMPILE_COMMANDS=ON \
         --update --skip_submodule_sync \
-        --build --parallel --target onnx_proto
+        --build --parallel --use_preset_compile_flags --target onnx_proto
     displayName: Generate compile_commands.json and ONNX protobuf files
 
   - script: |
diff --git a/tools/ci_build/github/azure-pipelines/nuget/templates/dml-vs-2022.yml b/tools/ci_build/github/azure-pipelines/nuget/templates/dml-vs-2022.yml
index 4e7093f04a59f..eb0e952547820 100644
--- a/tools/ci_build/github/azure-pipelines/nuget/templates/dml-vs-2022.yml
+++ b/tools/ci_build/github/azure-pipelines/nuget/templates/dml-vs-2022.yml
@@ -103,7 +103,7 @@ stages:
         displayName: 'Generate cmake config'
         inputs:
           scriptPath: '$(Build.SourcesDirectory)\tools\ci_build\build.py'
-          arguments: '$(BuildCommand) --path_to_protoc_exe $(Build.BinariesDirectory)\installed\bin\protoc.exe --build_csharp --update --config $(BuildConfig) ${{ variables.build_py_lto_flag }}'
+          arguments: '$(BuildCommand) --use_preset_compile_flags --parallel --path_to_protoc_exe $(Build.BinariesDirectory)\installed\bin\protoc.exe --build_csharp --update --config $(BuildConfig) ${{ variables.build_py_lto_flag }}'
           workingDirectory: '$(Build.BinariesDirectory)'
 
       - ${{ if notIn(parameters['sln_platform'], 'Win32', 'x64') }}:
@@ -176,7 +176,7 @@ stages:
              python.exe -m pip install -q --upgrade %WHEEL_FILENAME%
              set PATH=%PATH%;$(Build.BinariesDirectory)\$(BuildConfig)\$(BuildConfig)
              @echo %PATH%
-             python $(Build.SourcesDirectory)\tools\ci_build\build.py $(BuildCommand) --test --config $(BuildConfig) ${{ variables.build_py_lto_flag }}
+             python $(Build.SourcesDirectory)\tools\ci_build\build.py $(BuildCommand) --parallel --use_preset_compile_flags --test --config $(BuildConfig) ${{ variables.build_py_lto_flag }}
             workingDirectory: '$(Build.BinariesDirectory)\$(BuildConfig)\$(BuildConfig)'
             displayName: 'Run tests'
 
diff --git a/tools/ci_build/github/azure-pipelines/orttraining-linux-ci-pipeline.yml b/tools/ci_build/github/azure-pipelines/orttraining-linux-ci-pipeline.yml
index 26fd5e1ec0b5d..351114426b8a3 100644
--- a/tools/ci_build/github/azure-pipelines/orttraining-linux-ci-pipeline.yml
+++ b/tools/ci_build/github/azure-pipelines/orttraining-linux-ci-pipeline.yml
@@ -102,7 +102,7 @@ jobs:
               --config Release \
               --skip_submodule_sync \
               --build_shared_lib \
-              --parallel \
+              --parallel --use_preset_compile_flags \
               --build_wheel \
               --enable_onnx_tests \
               --enable_training \
diff --git a/tools/ci_build/github/azure-pipelines/orttraining-py-packaging-pipeline-cpu.yml b/tools/ci_build/github/azure-pipelines/orttraining-py-packaging-pipeline-cpu.yml
index a44a8c215939f..61b50ffbe79d7 100644
--- a/tools/ci_build/github/azure-pipelines/orttraining-py-packaging-pipeline-cpu.yml
+++ b/tools/ci_build/github/azure-pipelines/orttraining-py-packaging-pipeline-cpu.yml
@@ -69,7 +69,7 @@ stages:
                   --config Debug Release \
                   --skip_submodule_sync \
                   --build_shared_lib \
-                  --parallel \
+                  --parallel --use_preset_compile_flags \
                   --build_wheel \
                   --enable_onnx_tests \
                   --enable_pybind --enable_training
diff --git a/tools/ci_build/github/azure-pipelines/qnn-ep-nuget-packaging-pipeline.yml b/tools/ci_build/github/azure-pipelines/qnn-ep-nuget-packaging-pipeline.yml
index 47d97787d3b9e..bb417fe2356aa 100644
--- a/tools/ci_build/github/azure-pipelines/qnn-ep-nuget-packaging-pipeline.yml
+++ b/tools/ci_build/github/azure-pipelines/qnn-ep-nuget-packaging-pipeline.yml
@@ -37,7 +37,7 @@ jobs:
       buildArch: x64
       setVcvars: true
       ALLOW_RELEASED_ONNX_OPSET_ONLY: '1'
-      commonBuildArgs: '--compile_no_warning_as_error --build_dir $(Build.BinariesDirectory)\Windows --skip_submodule_sync --build_shared_lib --cmake_generator "Visual Studio 17 2022" --config ${{ parameters.build_config }} --use_qnn --qnn_home C:\data\qnnsdk\${{parameters.QnnSdk}} --parallel'
+      commonBuildArgs: '--compile_no_warning_as_error --build_dir $(Build.BinariesDirectory)\Windows --skip_submodule_sync --build_shared_lib --cmake_generator "Visual Studio 17 2022" --config ${{ parameters.build_config }} --use_qnn --qnn_home C:\data\qnnsdk\${{parameters.QnnSdk}} --parallel --use_preset_compile_flags '
 
     steps:
       - template: templates/set-version-number-variables-step.yml
diff --git a/tools/ci_build/github/azure-pipelines/templates/c-api-linux-cpu.yml b/tools/ci_build/github/azure-pipelines/templates/c-api-linux-cpu.yml
index cf470b3fa2448..28d55996484bc 100644
--- a/tools/ci_build/github/azure-pipelines/templates/c-api-linux-cpu.yml
+++ b/tools/ci_build/github/azure-pipelines/templates/c-api-linux-cpu.yml
@@ -64,7 +64,7 @@ jobs:
           docker run --rm --volume /data/onnx:/data/onnx:ro --volume $(Build.SourcesDirectory):/onnxruntime_src --volume $(Build.BinariesDirectory):/build \
           --volume $HOME/.onnx:/home/onnxruntimedev/.onnx -e NIGHTLY_BUILD onnxruntimecpubuildcentos8${{parameters.OnnxruntimeArch}} /bin/bash -c "python3.9 \
           /onnxruntime_src/tools/ci_build/build.py --enable_lto --build_java --build_nodejs --build_dir /build --config Release \
-          --skip_submodule_sync  --parallel --build_shared_lib ${{ parameters.AdditionalBuildFlags }} && cd /build/Release && make install DESTDIR=/build/linux-${{parameters.OnnxruntimeArch}}"
+          --skip_submodule_sync --parallel --use_preset_compile_flags --build_shared_lib ${{ parameters.AdditionalBuildFlags }} && cd /build/Release && make install DESTDIR=/build/linux-${{parameters.OnnxruntimeArch}}"
         workingDirectory: $(Build.SourcesDirectory)
       displayName: 'Build'
 
diff --git a/tools/ci_build/github/azure-pipelines/templates/jobs/win-ci-vs-2022-job.yml b/tools/ci_build/github/azure-pipelines/templates/jobs/win-ci-vs-2022-job.yml
index e40c4d0e95dc5..961b198b661e9 100644
--- a/tools/ci_build/github/azure-pipelines/templates/jobs/win-ci-vs-2022-job.yml
+++ b/tools/ci_build/github/azure-pipelines/templates/jobs/win-ci-vs-2022-job.yml
@@ -138,7 +138,7 @@ jobs:
       Today: $(TODAY)
       CacheDir: $(ORT_CACHE_DIR)
       AdditionalKey: " $(System.StageName) | ${{ parameters.BuildConfig }} "
-      BuildPyArguments: '--config ${{ parameters.BuildConfig }} --build_dir $(Build.BinariesDirectory) --skip_submodule_sync --build_csharp --update --parallel --cmake_generator "Visual Studio 17 2022" --build_shared_lib --enable_onnx_tests ${{ parameters.additionalBuildFlags }}'
+      BuildPyArguments: '--config ${{ parameters.BuildConfig }} --build_dir $(Build.BinariesDirectory) --skip_submodule_sync --build_csharp --update --parallel  --use_preset_compile_flags --cmake_generator "Visual Studio 17 2022" --build_shared_lib --enable_onnx_tests ${{ parameters.additionalBuildFlags }}'
       MsbuildArguments: '-maxcpucount'
       BuildArch: ${{ parameters.buildArch }}
       Platform: ${{ parameters.msbuildPlatform }}
diff --git a/tools/ci_build/github/azure-pipelines/templates/mac-cpu-packaging-steps.yml b/tools/ci_build/github/azure-pipelines/templates/mac-cpu-packaging-steps.yml
index 0cb77e222af93..e8d2b8a8075e9 100644
--- a/tools/ci_build/github/azure-pipelines/templates/mac-cpu-packaging-steps.yml
+++ b/tools/ci_build/github/azure-pipelines/templates/mac-cpu-packaging-steps.yml
@@ -47,14 +47,14 @@ steps:
     BuildStep:
       - script: |
           rm -rf $(Build.BinariesDirectory)/Release
-          python3 $(Build.SourcesDirectory)/tools/ci_build/build.py --update --build ${{ parameters.AdditionalBuildFlags }} --build_dir $(Build.BinariesDirectory) --skip_submodule_sync --parallel --build_shared_lib --config Release
+          python3 $(Build.SourcesDirectory)/tools/ci_build/build.py --update --build ${{ parameters.AdditionalBuildFlags }} --build_dir $(Build.BinariesDirectory) --skip_submodule_sync --parallel --use_preset_compile_flags --build_shared_lib --config Release
         displayName: 'Build ${{ parameters.MacosArch }}'
         env:
           CCACHE_DIR: ${{ parameters.CacheDir }}
 
 - ${{ if eq(parameters.MacosArch, 'x86_64') }}:
   - script: |
-      python3 $(Build.SourcesDirectory)/tools/ci_build/build.py --test  ${{ parameters.AdditionalBuildFlags }} --build_dir $(Build.BinariesDirectory) --skip_submodule_sync --parallel --build_shared_lib --config Release
+      python3 $(Build.SourcesDirectory)/tools/ci_build/build.py --test  ${{ parameters.AdditionalBuildFlags }} --build_dir $(Build.BinariesDirectory) --skip_submodule_sync --parallel --use_preset_compile_flags --build_shared_lib --config Release
     displayName: 'Running Tests'
 
 - task: ShellScript@2
diff --git a/tools/ci_build/github/azure-pipelines/templates/py-packaging-stage.yml b/tools/ci_build/github/azure-pipelines/templates/py-packaging-stage.yml
index 8669a883c31f1..8152b1610cac8 100644
--- a/tools/ci_build/github/azure-pipelines/templates/py-packaging-stage.yml
+++ b/tools/ci_build/github/azure-pipelines/templates/py-packaging-stage.yml
@@ -177,7 +177,7 @@ stages:
             --enable_pybind
             --enable_onnx_tests
             ${{ parameters.build_py_parameters }}
-            --parallel --update
+            --parallel --use_preset_compile_flags --update
             $(TelemetryOption)
           workingDirectory: '$(Build.BinariesDirectory)'
 
@@ -383,7 +383,7 @@ stages:
           set -e -x
           export _PYTHON_HOST_PLATFORM=macosx-${{variables.MACOSX_DEPLOYMENT_TARGET}}-universal2
           python3 -m pip install -r '$(Build.SourcesDirectory)/tools/ci_build/github/linux/docker/scripts/requirements.txt'
-          python3 $(Build.SourcesDirectory)/tools/ci_build/build.py --build_dir $(Build.BinariesDirectory) --use_coreml --skip_submodule_sync --parallel --config Release --build_wheel ${{ parameters.build_py_parameters }} --use_coreml --cmake_extra_defines CMAKE_OSX_ARCHITECTURES="arm64;x86_64" --update --build
+          python3 $(Build.SourcesDirectory)/tools/ci_build/build.py --build_dir $(Build.BinariesDirectory) --use_coreml --skip_submodule_sync --parallel --use_preset_compile_flags --config Release --build_wheel ${{ parameters.build_py_parameters }} --use_coreml --cmake_extra_defines CMAKE_OSX_ARCHITECTURES="arm64;x86_64" --update --build
         displayName: 'Command Line Script'
 
       - script: |
diff --git a/tools/ci_build/github/azure-pipelines/templates/py-packaging-training-cuda-stage.yml b/tools/ci_build/github/azure-pipelines/templates/py-packaging-training-cuda-stage.yml
index 158037661f072..0b600eb5ac91c 100644
--- a/tools/ci_build/github/azure-pipelines/templates/py-packaging-training-cuda-stage.yml
+++ b/tools/ci_build/github/azure-pipelines/templates/py-packaging-training-cuda-stage.yml
@@ -171,7 +171,7 @@ stages:
                   --build_dir /build \
                   --config ${{ variables['buildConfig'] }} \
                   --skip_submodule_sync \
-                  --parallel \
+                  --parallel --use_preset_compile_flags \
                   --build_wheel \
                   --enable_onnx_tests \
                   ${{ parameters.build_py_parameters }} \
diff --git a/tools/ci_build/github/azure-pipelines/templates/py-win-gpu.yml b/tools/ci_build/github/azure-pipelines/templates/py-win-gpu.yml
index c83e130dd26e8..6846979e73cb7 100644
--- a/tools/ci_build/github/azure-pipelines/templates/py-win-gpu.yml
+++ b/tools/ci_build/github/azure-pipelines/templates/py-win-gpu.yml
@@ -110,13 +110,13 @@ jobs:
         inputs:
           scriptPath: '$(Build.SourcesDirectory)\tools\ci_build\build.py'
           arguments: >
-            --config RelWithDebInfo --enable_qspectre
+            --config RelWithDebInfo
             --build_dir $(Build.BinariesDirectory)
             --skip_submodule_sync
             --cmake_generator "$(VSGenerator)"
             --enable_pybind
             --enable_onnx_tests
-            --parallel --update
+            --parallel --use_preset_compile_flags --update
             $(TelemetryOption) ${{ parameters.BUILD_PY_PARAMETERS }} ${{ parameters.EP_BUILD_FLAGS }}
           workingDirectory: '$(Build.BinariesDirectory)'
 
diff --git a/tools/ci_build/github/azure-pipelines/templates/win-ci.yml b/tools/ci_build/github/azure-pipelines/templates/win-ci.yml
index 31e41eb4bc2d7..992fa5ca9fbb0 100644
--- a/tools/ci_build/github/azure-pipelines/templates/win-ci.yml
+++ b/tools/ci_build/github/azure-pipelines/templates/win-ci.yml
@@ -150,9 +150,9 @@ stages:
         inputs:
           scriptPath: '$(Build.SourcesDirectory)\tools\ci_build\build.py'
           ${{ if eq(parameters['UseIncreasedTimeoutForTests'], 'true') }}:
-            arguments: '--config RelWithDebInfo --enable_qspectre --enable_lto --disable_rtti --build_dir $(Build.BinariesDirectory) --skip_submodule_sync --build_shared_lib --update --cmake_generator "$(VSGenerator)" --enable_onnx_tests $(TelemetryOption) ${{ parameters.buildparameter }} --test_all_timeout 72000'
+            arguments: '--config RelWithDebInfo --use_preset_compile_flags --enable_lto --disable_rtti --build_dir $(Build.BinariesDirectory) --skip_submodule_sync --build_shared_lib --update --cmake_generator "$(VSGenerator)" --enable_onnx_tests $(TelemetryOption) ${{ parameters.buildparameter }} --test_all_timeout 72000'
           ${{ else }}:
-            arguments: '--config RelWithDebInfo --enable_qspectre --enable_lto --disable_rtti --build_dir $(Build.BinariesDirectory) --skip_submodule_sync --build_shared_lib --update --cmake_generator "$(VSGenerator)" --enable_onnx_tests $(TelemetryOption) ${{ parameters.buildparameter }} '
+            arguments: '--config RelWithDebInfo --use_preset_compile_flags --enable_lto --disable_rtti --build_dir $(Build.BinariesDirectory) --skip_submodule_sync --build_shared_lib --update --cmake_generator "$(VSGenerator)" --enable_onnx_tests $(TelemetryOption) ${{ parameters.buildparameter }} '
           workingDirectory: '$(Build.BinariesDirectory)'
 
       - task: VSBuild@1
@@ -172,7 +172,7 @@ stages:
         condition: and(succeeded(), eq('${{ parameters.runTests}}', true))
         inputs:
           scriptPath: '$(Build.SourcesDirectory)\tools\ci_build\build.py'
-          arguments: '--config RelWithDebInfo --enable_qspectre --enable_lto --disable_rtti --build_dir $(Build.BinariesDirectory) --skip_submodule_sync --build_shared_lib --test --cmake_generator "$(VSGenerator)" --enable_onnx_tests  $(TelemetryOption) ${{ parameters.buildparameter }}'
+          arguments: '--config RelWithDebInfo --use_preset_compile_flags --enable_lto --disable_rtti --build_dir $(Build.BinariesDirectory) --skip_submodule_sync --build_shared_lib --test --cmake_generator "$(VSGenerator)" --enable_onnx_tests  $(TelemetryOption) ${{ parameters.buildparameter }}'
           workingDirectory: '$(Build.BinariesDirectory)'
 
       - script: |
diff --git a/tools/ci_build/github/azure-pipelines/win-ci-pipeline.yml b/tools/ci_build/github/azure-pipelines/win-ci-pipeline.yml
index d65b75ba9ede1..27e86cd917596 100644
--- a/tools/ci_build/github/azure-pipelines/win-ci-pipeline.yml
+++ b/tools/ci_build/github/azure-pipelines/win-ci-pipeline.yml
@@ -74,7 +74,7 @@ stages:
         displayName: 'Build and Test'
         inputs:
           scriptPath: '$(Build.SourcesDirectory)\tools\ci_build\build.py'
-          arguments: --config Debug --build_dir $(Build.BinariesDirectory) --skip_submodule_sync --parallel --cmake_generator "Visual Studio 17 2022" --disable_memleak_checker --enable_address_sanitizer
+          arguments: --config Debug --build_dir $(Build.BinariesDirectory) --skip_submodule_sync --parallel --use_preset_compile_flags --cmake_generator "Visual Studio 17 2022" --disable_memleak_checker --enable_address_sanitizer
           workingDirectory: '$(Build.BinariesDirectory)'
 
 
diff --git a/tools/ci_build/github/azure-pipelines/win-gpu-tensorrt-ci-pipeline.yml b/tools/ci_build/github/azure-pipelines/win-gpu-tensorrt-ci-pipeline.yml
index 2c4e4eb011783..802438d382d9e 100644
--- a/tools/ci_build/github/azure-pipelines/win-gpu-tensorrt-ci-pipeline.yml
+++ b/tools/ci_build/github/azure-pipelines/win-gpu-tensorrt-ci-pipeline.yml
@@ -54,7 +54,7 @@ jobs:
       WithCache: True
       Today: $(TODAY)
       AdditionalKey: "gpu-tensorrt | RelWithDebInfo"
-      BuildPyArguments: '--config RelWithDebInfo --enable_qspectre --build_dir $(Build.BinariesDirectory) --skip_submodule_sync --build_shared_lib --update --cmake_generator "Visual Studio 17 2022" --build_wheel --enable_onnx_tests --use_tensorrt --tensorrt_home="C:\local\TensorRT-8.6.1.6.Windows10.x86_64.cuda-11.8" --cuda_home="$(Agent.TempDirectory)\v11.8" --cmake_extra_defines CMAKE_CUDA_ARCHITECTURES=75'
+      BuildPyArguments: '--config RelWithDebInfo --parallel --use_preset_compile_flags --build_dir $(Build.BinariesDirectory) --skip_submodule_sync --build_shared_lib --update --cmake_generator "Visual Studio 17 2022" --build_wheel --enable_onnx_tests --use_tensorrt --tensorrt_home="C:\local\TensorRT-8.6.1.6.Windows10.x86_64.cuda-11.8" --cuda_home="$(Agent.TempDirectory)\v11.8" --cmake_extra_defines CMAKE_CUDA_ARCHITECTURES=75'
       MsbuildArguments: $(MsbuildArguments)
       BuildArch: 'x64'
       Platform: 'x64'
@@ -74,7 +74,7 @@ jobs:
      del wheel_filename_file
      python.exe -m pip install -q --upgrade %WHEEL_FILENAME%
      set PATH=$(Build.BinariesDirectory)\RelWithDebInfo\RelWithDebInfo;%PATH%
-     python $(Build.SourcesDirectory)\tools\ci_build\build.py --config RelWithDebInfo --enable_qspectre --build_dir $(Build.BinariesDirectory) --skip_submodule_sync --build_shared_lib --test --cmake_generator "Visual Studio 17 2022" --build_wheel --enable_onnx_tests --use_tensorrt --tensorrt_home="C:\local\TensorRT-8.6.1.6.Windows10.x86_64.cuda-11.8"  --cuda_home="$(Agent.TempDirectory)\v11.8" --cmake_extra_defines CMAKE_CUDA_ARCHITECTURES=75
+     python $(Build.SourcesDirectory)\tools\ci_build\build.py --config RelWithDebInfo --use_preset_compile_flags --build_dir $(Build.BinariesDirectory) --skip_submodule_sync --build_shared_lib --test --cmake_generator "Visual Studio 17 2022" --build_wheel --enable_onnx_tests --use_tensorrt --tensorrt_home="C:\local\TensorRT-8.6.1.6.Windows10.x86_64.cuda-11.8"  --cuda_home="$(Agent.TempDirectory)\v11.8" --cmake_extra_defines CMAKE_CUDA_ARCHITECTURES=75
 
     workingDirectory: '$(Build.BinariesDirectory)\RelWithDebInfo\RelWithDebInfo'
     displayName: 'Run tests'
diff --git a/tools/ci_build/github/azure-pipelines/win-qnn-ci-pipeline.yml b/tools/ci_build/github/azure-pipelines/win-qnn-ci-pipeline.yml
index c686fc57ab5f1..2e9b19f589c19 100644
--- a/tools/ci_build/github/azure-pipelines/win-qnn-ci-pipeline.yml
+++ b/tools/ci_build/github/azure-pipelines/win-qnn-ci-pipeline.yml
@@ -76,7 +76,7 @@ jobs:
       WithCache: True
       Today: $(TODAY)
       AdditionalKey: "win-qnn | $(BuildConfig)"
-      BuildPyArguments: '--config $(BuildConfig) --build_dir $(Build.BinariesDirectory) --compile_no_warning_as_error --update --cmake_generator "Visual Studio 17 2022" --use_qnn --qnn_home $(QNN_SDK_ROOT) --parallel'
+      BuildPyArguments: '--config $(BuildConfig) --build_dir $(Build.BinariesDirectory) --compile_no_warning_as_error --update --cmake_generator "Visual Studio 17 2022" --use_qnn --qnn_home $(QNN_SDK_ROOT) --parallel --use_preset_compile_flags'
       MsbuildArguments: $(MsbuildArguments)
       BuildArch: $(buildArch)
       Platform: 'x64'
diff --git a/tools/ci_build/github/linux/build_cuda_c_api_package.sh b/tools/ci_build/github/linux/build_cuda_c_api_package.sh
index 106536c0093b8..2482bfe825386 100755
--- a/tools/ci_build/github/linux/build_cuda_c_api_package.sh
+++ b/tools/ci_build/github/linux/build_cuda_c_api_package.sh
@@ -4,6 +4,6 @@ docker run --gpus all -e NVIDIA_VISIBLE_DEVICES=all --rm --volume \
 $BUILD_SOURCESDIRECTORY:/onnxruntime_src --volume $BUILD_BINARIESDIRECTORY:/build \
 --volume /data/models:/build/models:ro --volume /data/onnx:/data/onnx:ro -e NIGHTLY_BUILD onnxruntimecuda${CUDA_VERSION_MAJOR}build \
 /usr/bin/python3.9 /onnxruntime_src/tools/ci_build/build.py --enable_lto --build_java --build_nodejs --build_dir /build --config Release \
---skip_submodule_sync  --parallel --build_shared_lib --use_cuda --cuda_version=$CUDA_VERSION \
+--skip_submodule_sync  --parallel --use_preset_compile_flags --build_shared_lib --use_cuda --cuda_version=$CUDA_VERSION \
 --cuda_home=/usr/local/cuda-$CUDA_VERSION --cudnn_home=/usr/local/cuda-$CUDA_VERSION \
 --cmake_extra_defines 'CMAKE_CUDA_ARCHITECTURES=60;61;70;75;80'
diff --git a/tools/ci_build/github/linux/build_linux_python_package.sh b/tools/ci_build/github/linux/build_linux_python_package.sh
index 933d1f3d5874a..a0f5c6a7254a0 100755
--- a/tools/ci_build/github/linux/build_linux_python_package.sh
+++ b/tools/ci_build/github/linux/build_linux_python_package.sh
@@ -23,7 +23,7 @@ c) BUILD_CONFIG=${OPTARG};;
 esac
 done
 
-BUILD_ARGS=("--build_dir" "/build" "--config" "$BUILD_CONFIG" "--update" "--build" "--skip_submodule_sync" "--parallel" "--build_wheel")
+BUILD_ARGS=("--build_dir" "/build" "--config" "$BUILD_CONFIG" "--update" "--build" "--skip_submodule_sync" "--parallel" "--use_preset_compile_flags" "--build_wheel")
 
 if [ "$BUILD_CONFIG" != "Debug" ]; then
     BUILD_ARGS+=("--enable_lto")
diff --git a/tools/ci_build/github/linux/build_tensorrt_c_api_package.sh b/tools/ci_build/github/linux/build_tensorrt_c_api_package.sh
index a65be0cb6baa8..84c06f2dd5978 100755
--- a/tools/ci_build/github/linux/build_tensorrt_c_api_package.sh
+++ b/tools/ci_build/github/linux/build_tensorrt_c_api_package.sh
@@ -4,4 +4,4 @@ mkdir -p $HOME/.onnx
 docker run --gpus all -e CFLAGS -e CXXFLAGS -e NVIDIA_VISIBLE_DEVICES=all --rm --volume /data/onnx:/data/onnx:ro --volume $BUILD_SOURCESDIRECTORY:/onnxruntime_src --volume $BUILD_BINARIESDIRECTORY:/build \
 --volume /data/models:/build/models:ro --volume $HOME/.onnx:/home/onnxruntimedev/.onnx -e NIGHTLY_BUILD onnxruntimecuda${CUDA_VERSION_MAJOR}xtrt86build \
 /opt/python/cp38-cp38/bin/python3 /onnxruntime_src/tools/ci_build/build.py --build_dir /build --config Release \
---skip_submodule_sync --parallel --build_shared_lib --build_java --build_nodejs --use_tensorrt --cuda_version=$CUDA_VERSION --cuda_home=/usr/local/cuda-$CUDA_VERSION --cudnn_home=/usr --tensorrt_home=/usr --cmake_extra_defines 'CMAKE_CUDA_ARCHITECTURES=60;61;70;75;80'
+--skip_submodule_sync --parallel --use_preset_compile_flags --build_shared_lib --build_java --build_nodejs --use_tensorrt --cuda_version=$CUDA_VERSION --cuda_home=/usr/local/cuda-$CUDA_VERSION --cudnn_home=/usr --tensorrt_home=/usr --cmake_extra_defines 'CMAKE_CUDA_ARCHITECTURES=60;61;70;75;80'
diff --git a/tools/ci_build/github/linux/ort_minimal/build_full_ort_and_create_ort_files.sh b/tools/ci_build/github/linux/ort_minimal/build_full_ort_and_create_ort_files.sh
index b35bbfbd517d2..1d3f25df61bbb 100755
--- a/tools/ci_build/github/linux/ort_minimal/build_full_ort_and_create_ort_files.sh
+++ b/tools/ci_build/github/linux/ort_minimal/build_full_ort_and_create_ort_files.sh
@@ -22,7 +22,7 @@ python3 /onnxruntime_src/tools/ci_build/build.py \
     --build_dir ${BUILD_DIR} --cmake_generator Ninja \
     --config Debug \
     --skip_submodule_sync \
-    --parallel \
+    --parallel --use_preset_compile_flags \
     --build_wheel \
     --skip_tests \
     --enable_training_ops \
diff --git a/tools/ci_build/github/linux/ort_minimal/build_minimal_ort_and_run_tests.sh b/tools/ci_build/github/linux/ort_minimal/build_minimal_ort_and_run_tests.sh
index 2efcff917417b..c331fb4a27793 100755
--- a/tools/ci_build/github/linux/ort_minimal/build_minimal_ort_and_run_tests.sh
+++ b/tools/ci_build/github/linux/ort_minimal/build_minimal_ort_and_run_tests.sh
@@ -72,7 +72,7 @@ python3 /onnxruntime_src/tools/ci_build/build.py \
     --config Debug \
     --skip_submodule_sync \
     --build_shared_lib \
-    --parallel \
+    --parallel --use_preset_compile_flags \
     --minimal_build ${MINIMAL_BUILD_ARGS} \
     --disable_ml_ops \
     --include_ops_by_config ${REDUCED_OPS_CONFIG_FILE} \
diff --git a/tools/ci_build/github/linux/run_build.sh b/tools/ci_build/github/linux/run_build.sh
index 43e1543890e3e..a61712adf4369 100755
--- a/tools/ci_build/github/linux/run_build.sh
+++ b/tools/ci_build/github/linux/run_build.sh
@@ -37,7 +37,7 @@ if [ $BUILD_OS = "yocto" ]; then
 
     make -j$(nproc)
 else
-    COMMON_BUILD_ARGS="--skip_submodule_sync --enable_onnx_tests --parallel --cmake_path /usr/bin/cmake --ctest_path /usr/bin/ctest"
+    COMMON_BUILD_ARGS="--skip_submodule_sync --enable_onnx_tests --parallel --use_preset_compile_flags --cmake_path /usr/bin/cmake --ctest_path /usr/bin/ctest"
 
     if [ $BUILD_DEVICE = "gpu" ]; then
         _CUDNN_VERSION=$(echo $CUDNN_VERSION | cut -d. -f1-2)
diff --git a/tools/scripts/python_test.sh b/tools/scripts/python_test.sh
index bfdd4663feede..804905ad0cd68 100755
--- a/tools/scripts/python_test.sh
+++ b/tools/scripts/python_test.sh
@@ -24,5 +24,5 @@ python3 -m pip install $build_dir/$config/dist/*.whl
 
 echo Run $config unit tests
 pushd $build_dir/$config/
-python3 $src_dir/tools/ci_build/build.py --build_dir $build_dir --cmake_generator Ninja --config $config --test --skip_submodule_sync --build_shared_lib --parallel --build_wheel --enable_onnx_tests --enable_transformers_tool_test --ctest_path ""
+python3 $src_dir/tools/ci_build/build.py --build_dir $build_dir --cmake_generator Ninja --config $config --test --skip_submodule_sync --build_shared_lib --parallel --use_preset_compile_flags  --build_wheel --enable_onnx_tests --enable_transformers_tool_test --ctest_path ""
 popd